3WPG

Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 1)

Summary for 3WPG

• Entry DOI: 10.2210/pdb3wpg/pdb
• Related: 3WPB 3WPC 3WPD 3WPE 3WPF 3WPH 3WPI
• Descriptor: Toll-like receptor 9, DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3'), 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• Functional Keywords: leucine rich repeat, receptor, innate immunity, dna binding, glycosylation, cpg motif, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Mus musculus (mouse); More
• Total number of polymer chains: 2
• Total formula weight: 94601.53

Authors

Ohto, U.,Shimizu, T. (deposition date: 2014-01-11, release date: 2015-02-11, Last modification date: 2020-07-29)

• Primary citation: Ohto, U.,Shibata, T.,Tanji, H.,Ishida, H.,Krayukhina, E.,Uchiyama, S.,Miyake, K.,Shimizu, T.; Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9; Nature, 520:702-705, 2015; PubMed: 25686612; DOI: 10.1038/nature14138

Experimental method

X-RAY DIFFRACTION (2.246 Å)