3WPG
Crystal structure of mouse TLR9 in complex with inhibitory DNA4084 (form 1)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Toll-like receptor 9 | polymer | 803 | 90172.6 | 1 | UniProt (Q9EQU3) Pfam (PF18837) Pfam (PF13855) In PDB | Mus musculus (mouse) | |
2 | B | DNA (5'-D(*CP*CP*TP*GP*GP*AP*TP*GP*GP*GP*AP*A)-3') | polymer | 12 | 3727.4 | 1 | synthetic | ||
3 | A | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
4 | A, B | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
5 | water | water | 18.0 | 77 | Chemie (HOH) |
Sequence modifications
A: 26 - 818 (UniProt: Q9EQU3)
PDB | External Database | Details |
---|---|---|
Arg 22 | - | expression tag |
Ser 23 | - | expression tag |
Pro 24 | - | expression tag |
Trp 25 | - | expression tag |
Gln 200 | Asn 200 | engineered mutation |
Gln 242 | Asn 242 | engineered mutation |
Gln 309 | Asn 309 | engineered mutation |
Gln 495 | Asn 495 | engineered mutation |
Gln 568 | Asn 568 | engineered mutation |
Gln 695 | Asn 695 | engineered mutation |
Gln 752 | Asn 752 | engineered mutation |
Glu 819 | - | expression tag |
Phe 820 | - | expression tag |
Leu 821 | - | expression tag |
Val 822 | - | expression tag |
Pro 823 | - | expression tag |
Arg 824 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 93900.0 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 701.5 | |
All* | Total formula weight | 94601.5 |