8KCW
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![BU of 8kcw by Molmil](/molmil-images/mine/8kcw) | Cryo-EM structure of human SIDT1 bound to cholesterol | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SID1 transmembrane family member 1, ... | Authors: | Hirano, Y, Ohto, U, Shimizu, T. | Deposit date: | 2023-08-08 | Release date: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.77 Å) | Cite: | Cryo-EM analysis reveals human SID-1 transmembrane family member 1 dynamics underlying lipid hydrolytic activity. Commun Biol, 7, 2024
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7WSI
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7WBT
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![BU of 7wbt by Molmil](/molmil-images/mine/7wbt) | Crystal structure of bovine NLRP9 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | Authors: | Kamitsukasa, Y, Shimizu, T, Ohto, U. | Deposit date: | 2021-12-17 | Release date: | 2022-04-06 | Last modified: | 2022-04-27 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function. Febs Lett., 596, 2022
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7WBU
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![BU of 7wbu by Molmil](/molmil-images/mine/7wbu) | Cryo-EM structure of bovine NLRP9 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 9 | Authors: | Kamitsukasa, Y, Shimizu, T, Ohto, U. | Deposit date: | 2021-12-17 | Release date: | 2022-04-06 | Last modified: | 2024-06-26 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | The structure of NLRP9 reveals a unique C-terminal region with putative regulatory function. Febs Lett., 596, 2022
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3AK9
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![BU of 3ak9 by Molmil](/molmil-images/mine/3ak9) | Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis, FE-soaked form | Descriptor: | DNA protection during starvation protein, FE (II) ION, MAGNESIUM ION, ... | Authors: | Miyamoto, T, Asahina, Y, Miyazaki, S, Shimizu, H, Ohto, U, Noguchi, S, Satow, Y. | Deposit date: | 2010-07-08 | Release date: | 2011-01-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Structures of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis Acta Crystallogr.,Sect.F, 67, 2011
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3AK8
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![BU of 3ak8 by Molmil](/molmil-images/mine/3ak8) | Crystal structure of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis | Descriptor: | DNA protection during starvation protein, MAGNESIUM ION, SULFATE ION | Authors: | Miyamoto, T, Asahina, Y, Miyazaki, S, Shimizu, H, Ohto, U, Noguchi, S, Satow, Y. | Deposit date: | 2010-07-08 | Release date: | 2011-01-12 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Structures of the SEp22 dodecamer, a Dps-like protein from Salmonella enterica subsp. enterica serovar Enteritidis Acta Crystallogr.,Sect.F, 67, 2011
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7WGE
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![BU of 7wge by Molmil](/molmil-images/mine/7wge) | Human NLRP1 complexed with thioredoxin | Descriptor: | MAGNESIUM ION, NACHT, LRR and PYD domains-containing protein 1, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2021-12-28 | Release date: | 2023-07-05 | Last modified: | 2023-10-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis for thioredoxin-mediated suppression of NLRP1 inflammasome. Nature, 622, 2023
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7CRF
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![BU of 7crf by Molmil](/molmil-images/mine/7crf) | Crystal structure of human TLR8 in complex with CU-CPD107 | Descriptor: | 1-[2-(ethoxymethyl)-4-iodanyl-5-phenyl-imidazol-1-yl]-2-methyl-propan-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 8, ... | Authors: | Sakaniwa, K, Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2020-08-13 | Release date: | 2021-06-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun, 12, 2021
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7BQI
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![BU of 7bqi by Molmil](/molmil-images/mine/7bqi) | Crystal structure of FYCO1 RUN domain | Descriptor: | FYVE and coiled-coil domain-containing protein 1 | Authors: | Sakurai, S, Shimizu, T, Ohto, U. | Deposit date: | 2020-03-24 | Release date: | 2020-08-05 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Crystal structure of the FYCO1 RUN domain suggests possible interfaces with small GTPases. Acta Crystallogr.,Sect.F, 76, 2020
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6KYA
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![BU of 6kya by Molmil](/molmil-images/mine/6kya) | Crystal structure of human TLR8 in complex TH1027 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-methylsulfanyl-4-(3,4,5-trimethylphenyl)-1,2,4-triazol-3-yl]propan-1-ol, ... | Authors: | Tanji, H, Sakaniwa, K, Ohto, U, Shimizu, T. | Deposit date: | 2019-09-17 | Release date: | 2020-05-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Rationally Designed Small-Molecule Inhibitors Targeting an Unconventional Pocket on the TLR8 Protein-Protein Interface. J.Med.Chem., 63, 2020
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6LW1
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![BU of 6lw1 by Molmil](/molmil-images/mine/6lw1) | Cryo-EM structure of TLR7/Cpd-7 (DSR-139970) complex in open form | Descriptor: | 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-6-methyl-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purine, Toll-like receptor 7 | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LVZ
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![BU of 6lvz by Molmil](/molmil-images/mine/6lvz) | Crystal structure of TLR7/Cpd-3 (SM-394830) complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(pyridin-3-ylmethyl)-7H-purin-8-one, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LW0
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![BU of 6lw0 by Molmil](/molmil-images/mine/6lw0) | Crystal structure of TLR7/Cpd-6 (DSR-139293) complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-ethoxy-8-(5-fluoranylpyridin-3-yl)-9-[[4-[[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]methyl]phenyl]methyl]purin-6-amine, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LVY
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![BU of 6lvy by Molmil](/molmil-images/mine/6lvy) | Crystal structure of TLR7/Cpd-2 (SM-360320) complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-(2-methoxyethoxy)-9-(phenylmethyl)-7H-purin-8-one, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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6LVX
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![BU of 6lvx by Molmil](/molmil-images/mine/6lvx) | Crystal structure of TLR7/Cpd-1 (SM-374527) complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-azanyl-2-butoxy-9-(phenylmethyl)-7H-purin-8-one, ... | Authors: | Zhang, Z, Ohto, U, Shimizu, T. | Deposit date: | 2020-02-06 | Release date: | 2020-11-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Structural analysis reveals TLR7 dynamics underlying antagonism. Nat Commun, 11, 2020
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7WM4
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![BU of 7wm4 by Molmil](/molmil-images/mine/7wm4) | Cryo-EM structure of tetrameric TLR3 in complex with dsRNA (90 bp) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, RNA (81-MER), ... | Authors: | Sakaniwa, K, Ohto, U, Shimizu, T. | Deposit date: | 2022-01-14 | Release date: | 2023-01-25 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | TLR3 forms a laterally aligned multimeric complex along double-stranded RNA for efficient signal transduction. Nat Commun, 14, 2023
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7VAF
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![BU of 7vaf by Molmil](/molmil-images/mine/7vaf) | Cryo-EM structure of Rat NTCP complexed with YN69202Fab | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter | Authors: | Asami, J, Shimizu, T, Ohto, U. | Deposit date: | 2021-08-29 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.11 Å) | Cite: | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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7VAG
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7VAD
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![BU of 7vad by Molmil](/molmil-images/mine/7vad) | Cryo-EM structure of human NTCP complexed with YN69202Fab | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Sodium/bile acid cotransporter | Authors: | Asami, J, Shimizu, T, Ohto, U. | Deposit date: | 2021-08-29 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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7VAE
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![BU of 7vae by Molmil](/molmil-images/mine/7vae) | Cryo-EM structure of bovine NTCP complexed with YN69202Fab | Descriptor: | Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202, Solute carrier family 10 (Sodium/bile acid cotransporter family), ... | Authors: | Asami, J, Shimizu, T, Ohto, U. | Deposit date: | 2021-08-29 | Release date: | 2022-05-25 | Last modified: | 2022-07-13 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606, 2022
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7VGR
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![BU of 7vgr by Molmil](/molmil-images/mine/7vgr) | |
7VGS
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![BU of 7vgs by Molmil](/molmil-images/mine/7vgs) | |
5WYZ
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![BU of 5wyz by Molmil](/molmil-images/mine/5wyz) | Crystal structure of human TLR8 in complex with CU-CPT9b | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(3-methyl-4-oxidanyl-phenyl)quinolin-7-ol, ... | Authors: | Tanji, H, Ohto, U, Shimizu, T. | Deposit date: | 2017-01-16 | Release date: | 2017-12-13 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Small-molecule inhibition of TLR8 through stabilization of its resting state Nat. Chem. Biol., 14, 2018
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5XDR
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![BU of 5xdr by Molmil](/molmil-images/mine/5xdr) | Crystal structure of human DEAH-box RNA helicase DHX15 in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15, ... | Authors: | Murakami, K, Nakano, K, Shimizu, T, Ohto, U. | Deposit date: | 2017-03-29 | Release date: | 2017-06-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of human DEAH-box RNA helicase 15 reveals a domain organization of the mammalian DEAH/RHA family Acta Crystallogr F Struct Biol Commun, 73, 2017
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5WRD
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![BU of 5wrd by Molmil](/molmil-images/mine/5wrd) | Crystal structure of LC3B in complex with FYCO1 LIR | Descriptor: | GLYCEROL, Microtubule-associated proteins 1A/1B light chain 3B, Peptide from FYVE and coiled-coil domain-containing protein 1 | Authors: | Sakurai, S, Ohto, U, Shimizu, T. | Deposit date: | 2016-12-01 | Release date: | 2017-03-29 | Last modified: | 2020-02-26 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The crystal structure of mouse LC3B in complex with the FYCO1 LIR reveals the importance of the flanking region of the LIR motif Acta Crystallogr F Struct Biol Commun, 73, 2017
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