7WSI

Cryo-EM structure of human NTCP (wild-type) complexed with YN69202Fab

Summary for 7WSI

Entry DOI	10.2210/pdb7wsi/pdb
EMDB information	32759
Descriptor	Sodium/bile acid cotransporter, Fab heavy chain from antibody IgG clone number YN69202, Fab light chain from antibody IgG clone number YN69202 (3 entities in total)
Functional Keywords	hepatitis b virus (hbv), host entry receptor, bile acid transporter, taurocholate, na+-coupled symporter, transport protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	89097.57
Authors	Asami, J.,Shimizu, T.,Ohto, U. (deposition date: 2022-01-29, release date: 2022-05-25, Last modification date: 2022-07-13)
Primary citation	Asami, J.,Kimura, K.T.,Fujita-Fujiharu, Y.,Ishida, H.,Zhang, Z.,Nomura, Y.,Liu, K.,Uemura, T.,Sato, Y.,Ono, M.,Yamamoto, M.,Noda, T.,Shigematsu, H.,Drew, D.,Iwata, S.,Shimizu, T.,Nomura, N.,Ohto, U. Structure of the bile acid transporter and HBV receptor NTCP. Nature, 606:1021-1026, 2022 Cited by PubMed: 35580629 DOI: 10.1038/s41586-022-04845-4 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.32 Å)

Structure validation