7BPL
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![BU of 7bpl by Molmil](/molmil-images/mine/7bpl) | Solution NMR structure of NF1; de novo designed protein with a novel fold | Descriptor: | NF1 | Authors: | Kobayashi, N, Sugiki, T, Fujiwara, T, Minami, S, Koga, R, Chikenji, G, Koga, N. | Deposit date: | 2020-03-23 | Release date: | 2021-03-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Exploration of novel alpha-beta-protein folds through de novo design Nat.Struct.Mol.Biol., 2023
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7BPP
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![BU of 7bpp by Molmil](/molmil-images/mine/7bpp) | Solution NMR structure of NF5; de novo designed protein with a novel fold | Descriptor: | NF5 | Authors: | Kobayashi, N, Sugiki, T, Fujiwara, T, Minami, S, Koga, R, Chikenji, G, Koga, N. | Deposit date: | 2020-03-23 | Release date: | 2021-03-24 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Exploration of novel alpha-beta-protein folds through de novo design Nat.Struct.Mol.Biol., 2023
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6XY3
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6UMM
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![BU of 6umm by Molmil](/molmil-images/mine/6umm) | A complete structure of the ESX-3 translocon complex | Descriptor: | ESX-3 secretion system ATPase EccB3, ESX-3 secretion system protein EccC3, ESX-3 secretion system protein EccD3, ... | Authors: | Poweleit, N, Rosenberg, O.S. | Deposit date: | 2019-10-09 | Release date: | 2019-10-23 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A large inner membrane pore defines the ESX translocon To Be Published
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6XXF
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1ANS
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7PAF
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![BU of 7paf by Molmil](/molmil-images/mine/7paf) | Streptococcus pneumoniae choline importer LicB in lipid nanodiscs | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, LicB protein, Nanobody | Authors: | Perez, C, Baerland, N. | Deposit date: | 2021-07-29 | Release date: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Mechanistic basis of choline import involved in teichoic acids and lipopolysaccharide modification. Sci Adv, 8, 2022
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1AGQ
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![BU of 1agq by Molmil](/molmil-images/mine/1agq) | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR FROM RAT | Descriptor: | GLIAL CELL-DERIVED NEUROTROPHIC FACTOR | Authors: | Eigenbrot, C, Gerber, N. | Deposit date: | 1997-03-25 | Release date: | 1997-06-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | X-ray structure of glial cell-derived neurotrophic factor at 1.9 A resolution and implications for receptor binding. Nat.Struct.Biol., 4, 1997
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6MNY
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1A05
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![BU of 1a05 by Molmil](/molmil-images/mine/1a05) | CRYSTAL STRUCTURE OF THE COMPLEX OF 3-ISOPROPYLMALATE DEHYDROGENASE FROM THIOBACILLUS FERROOXIDANS WITH 3-ISOPROPYLMALATE | Descriptor: | 3-ISOPROPYLMALATE DEHYDROGENASE, 3-ISOPROPYLMALIC ACID, MAGNESIUM ION | Authors: | Imada, K, Inagaki, K, Matsunami, H, Kawaguchi, H, Tanaka, H, Tanaka, N, Namba, K. | Deposit date: | 1997-12-09 | Release date: | 1998-06-17 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of 3-isopropylmalate dehydrogenase in complex with 3-isopropylmalate at 2.0 A resolution: the role of Glu88 in the unique substrate-recognition mechanism. Structure, 6, 1998
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6C2C
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![BU of 6c2c by Molmil](/molmil-images/mine/6c2c) | The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme | Descriptor: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ZINC ION, ... | Authors: | Hong, N.-S, Jackson, C.J, Carr, P.D, Tokuriki, N, Baier, F, Yang, G. | Deposit date: | 2018-01-08 | Release date: | 2019-01-16 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.597 Å) | Cite: | Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme. Nat.Chem.Biol., 15, 2019
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1AN7
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1A41
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![BU of 1a41 by Molmil](/molmil-images/mine/1a41) | TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS | Descriptor: | SULFATE ION, TOPOISOMERASE I | Authors: | Cheng, C, Kussie, P, Pavletich, N, Shuman, S. | Deposit date: | 1998-02-10 | Release date: | 1999-06-01 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases. Cell(Cambridge,Mass.), 92, 1998
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6ZB6
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6Q73
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![BU of 6q73 by Molmil](/molmil-images/mine/6q73) | PI3K delta in complex with N[2chloro5(3,6dihydro2Hpyran4yl)pyridin3yl]methanesulfonamide | Descriptor: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, ~{N}-[2-chloranyl-5-(3,6-dihydro-2~{H}-pyran-4-yl)pyridin-3-yl]methanesulfonamide | Authors: | Convery, M.A, Rowland, P, Down, K, Barton, N. | Deposit date: | 2018-12-12 | Release date: | 2018-12-26 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Discovery of Potent, Efficient, and Selective Inhibitors of Phosphoinositide 3-Kinase delta through a Deconstruction and Regrowth Approach. J.Med.Chem., 61, 2018
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6VWS
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![BU of 6vws by Molmil](/molmil-images/mine/6vws) | Hexamer of Helical HIV capsid by RASTR method | Descriptor: | HIV capsid protein | Authors: | Zhao, H, Iqbal, N, Asturias, F, Kvaratskhelia, M, Vanblerkom, P. | Deposit date: | 2020-02-20 | Release date: | 2020-10-21 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (6.08 Å) | Cite: | Structural and mechanistic bases for a potent HIV-1 capsid inhibitor. Science, 370, 2020
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6T8V
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![BU of 6t8v by Molmil](/molmil-images/mine/6t8v) | Complement factor B in complex with (S)-5,7-Dimethyl-4-((2-phenylpiperidin-1-yl)methyl)-1H-indole | Descriptor: | 4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ... | Authors: | Mainolfi, N, Ehara, T, Karki, R.G, Anderson, K, Mac Sweeney, A, Wiesmann, C, Adams, C, Mainolfi, N, Liao, S.-M, Argikar, U.A, Jendza, K, Zhang, C, Powers, J, Klosowski, D.W, Crowley, M, Kawanami, T, Ding, J, April, M, Forster, C, Serrano-Wu, M, Capparelli, M, Ramqaj, R, Solovay, C, Cumin, F, Smith, T.M, Ferrara, L, Lee, W, Long, D, Prentiss, M, De Erkenez, A, Yang, L, Fang, L, Sellner, H, Sirockin, F, Valeur, E, Erbel, P, Ramage, P, Gerhartz, B, Schubart, A, Flohr, S, Gradoux, N, Feifel, R, Vogg, B, Wiesmann, C, Maibaum, J, Eder, J, Sedrani, R, Harrison, R.A, Mogi, M, Jaffee, B.D, Adams, C.M. | Deposit date: | 2019-10-25 | Release date: | 2020-03-04 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.29 Å) | Cite: | Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases. J.Med.Chem., 63, 2020
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1CCR
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![BU of 1ccr by Molmil](/molmil-images/mine/1ccr) | STRUCTURE OF RICE FERRICYTOCHROME C AT 2.0 ANGSTROMS RESOLUTION | Descriptor: | CYTOCHROME C, HEME C | Authors: | Ochi, H, Hata, Y, Tanaka, N, Kakudo, M, Sakurai, T, Aihara, S, Morita, Y. | Deposit date: | 1983-03-14 | Release date: | 1983-04-21 | Last modified: | 2021-03-03 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of rice ferricytochrome c at 2.0 A resolution. J.Mol.Biol., 166, 1983
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1C94
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![BU of 1c94 by Molmil](/molmil-images/mine/1c94) | REVERSING THE SEQUENCE OF THE GCN4 LEUCINE ZIPPER DOES NOT AFFECT ITS FOLD. | Descriptor: | RETRO-GCN4 LEUCINE ZIPPER | Authors: | Mittl, P.R.E, Deillon, C.A, Sargent, D, Liu, N, Klauser, S, Thomas, R.M, Gutte, B, Gruetter, M.G. | Deposit date: | 1999-07-30 | Release date: | 2000-03-22 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | The retro-GCN4 leucine zipper sequence forms a stable three-dimensional structure. Proc.Natl.Acad.Sci.USA, 97, 2000
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1CD9
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![BU of 1cd9 by Molmil](/molmil-images/mine/1cd9) | 2:2 COMPLEX OF G-CSF WITH ITS RECEPTOR | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (G-CSF RECEPTOR), PROTEIN (GRANULOCYTE COLONY-STIMULATING FACTOR) | Authors: | Aritomi, M, Kunishima, N, Okamoto, T, Kuroki, R, Ota, Y, Morikawa, K. | Deposit date: | 1999-03-08 | Release date: | 2000-03-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Atomic structure of the GCSF-receptor complex showing a new cytokine-receptor recognition scheme. Nature, 401, 1999
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5FUL
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![BU of 5ful by Molmil](/molmil-images/mine/5ful) | Crystal Structure of Mus musculus Protein Arginine Methyltransferase 2 with SAH | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ... | Authors: | Cura, V, Troffer-Charlier, N, Marechal, N, Bonnefond, L, Cavarelli, J. | Deposit date: | 2016-01-27 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structural studies of protein arginine methyltransferase 2 reveal its interactions with potential substrates and inhibitors. FEBS J., 284, 2017
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6BRO
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6Z4N
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![BU of 6z4n by Molmil](/molmil-images/mine/6z4n) | CRYSTAL STRUCTURE OF OASS COMPLEXED WITH UPAR INHIBITOR | Descriptor: | (1~{S},2~{S})-1-[(4-methylphenyl)methyl]-2-phenyl-cyclopropane-1-carboxylic acid, COBALT (II) ION, Cysteine synthase A, ... | Authors: | Demitri, N, Storici, P, Campanini, B. | Deposit date: | 2020-05-25 | Release date: | 2021-04-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O -Acetylserine Sulfhydrylase as a Colistin Adjuvant. Acs Infect Dis., 7, 2021
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2P2X
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![BU of 2p2x by Molmil](/molmil-images/mine/2p2x) | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 | Descriptor: | Probable diphthine synthase, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Sugahara, M, Ono, N, Taketa, M, Matsuura, Y, Kunishima, N, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2007-03-08 | Release date: | 2007-09-11 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of PH0725 from Pyrococcus horikoshii OT3 To be Published
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2P5R
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![BU of 2p5r by Molmil](/molmil-images/mine/2p5r) | Crystal structure of the poplar glutathione peroxidase 5 in the oxidized form | Descriptor: | CALCIUM ION, Glutathione peroxidase 5 | Authors: | Koh, C.S, Didierjean, C, Navrot, N, Panjikar, S, Mulliert, G, Rouhier, N, Jacquot, J.-P, Aubry, A, Shawkataly, O, Corbier, C. | Deposit date: | 2007-03-16 | Release date: | 2007-07-24 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal Structures of a Poplar Thioredoxin Peroxidase that Exhibits the Structure of Glutathione Peroxidases: Insights into Redox-driven Conformational Changes. J.Mol.Biol., 370, 2007
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