6C2C
The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme
Summary for 6C2C
Entry DOI | 10.2210/pdb6c2c/pdb |
Descriptor | dihydrocoumarin hydrolase, AncDHCH1, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphatase, directed evolution, methyl-parathion hydrolase (mph), hydrolase, a xenobiotic degrading enzyme |
Biological source | Pseudomonas sp. |
Total number of polymer chains | 2 |
Total formula weight | 63557.91 |
Authors | Hong, N.-S.,Jackson, C.J.,Carr, P.D.,Tokuriki, N.,Baier, F.,Yang, G. (deposition date: 2018-01-08, release date: 2019-01-16, Last modification date: 2024-03-13) |
Primary citation | Yang, G.,Anderson, D.W.,Baier, F.,Dohmen, E.,Hong, N.,Carr, P.D.,Kamerlin, S.C.L.,Jackson, C.J.,Bornberg-Bauer, E.,Tokuriki, N. Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme. Nat.Chem.Biol., 15:1120-1128, 2019 Cited by PubMed: 31636435DOI: 10.1038/s41589-019-0386-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.597 Å) |
Structure validation
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