6MNY
Crystal structure of mouse BTK kinase domain in complex with compound 9a
Summary for 6MNY
Entry DOI | 10.2210/pdb6mny/pdb |
Descriptor | Tyrosine-protein kinase, 5-amino-1-[(3R)-1-cyanopiperidin-3-yl]-3-[4-(2,4-difluorophenoxy)phenyl]-1H-pyrazole-4-carboxamide (3 entities in total) |
Functional Keywords | kinase, drug design, transferase |
Biological source | Mus musculus (Mouse) |
Total number of polymer chains | 2 |
Total formula weight | 64513.87 |
Authors | |
Primary citation | Schnute, M.E.,Benoit, S.E.,Buchler, I.P.,Caspers, N.,Grapperhaus, M.L.,Han, S.,Hotchandani, R.,Huang, N.,Hughes, R.O.,Juba, B.M.,Kim, K.H.,Liu, E.,McCarthy, E.,Messing, D.,Miyashiro, J.S.,Mohan, S.,O'Connell, T.N.,Ohren, J.F.,Parikh, M.D.,Schmidt, M.,Selness, S.R.,Springer, J.R.,Thanabal, V.,Trujillo, J.I.,Walker, D.P.,Wan, Z.K.,Withka, J.M.,Wittwer, A.J.,Wood, N.L.,Xing, L.,Zapf, C.W.,Douhan III, J. Aminopyrazole Carboxamide Bruton's Tyrosine Kinase Inhibitors. Irreversible to Reversible Covalent Reactive Group Tuning. ACS Med Chem Lett, 10:80-85, 2019 Cited by PubMed: 30655951DOI: 10.1021/acsmedchemlett.8b00461 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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