6Z4N

CRYSTAL STRUCTURE OF OASS COMPLEXED WITH UPAR INHIBITOR

This is a non-PDB format compatible entry.

Summary for 6Z4N

• Entry DOI: 10.2210/pdb6z4n/pdb
• Descriptor: Cysteine synthase A, PYRIDOXAL-5'-PHOSPHATE, (1~{S},2~{S})-1-[(4-methylphenyl)methyl]-2-phenyl-cyclopropane-1-carboxylic acid, ... (7 entities in total)
• Functional Keywords: cystein biosynthesis, beta replacement enzyme, plp dependent enzyme, homodimer, lyase, inhibitor
• Biological source: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2
• Total number of polymer chains: 2
• Total formula weight: 71008.08

Authors

Demitri, N.,Storici, P.,Campanini, B. (deposition date: 2020-05-25, release date: 2021-04-07, Last modification date: 2024-01-24)

• Primary citation: Annunziato, G.,Spadini, C.,Franko, N.,Storici, P.,Demitri, N.,Pieroni, M.,Flisi, S.,Rosati, L.,Iannarelli, M.,Marchetti, M.,Magalhaes, J.,Bettati, S.,Mozzarelli, A.,Cabassi, C.S.,Campanini, B.,Costantino, G.; Investigational Studies on a Hit Compound Cyclopropane-Carboxylic Acid Derivative Targeting O -Acetylserine Sulfhydrylase as a Colistin Adjuvant.; Acs Infect Dis., 7:281-292, 2021; PubMed: 33513010; DOI: 10.1021/acsinfecdis.0c00378

Experimental method

X-RAY DIFFRACTION (1.2 Å)