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PDB: 100 件
2QQR
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BU of 2qqr by Molmil
JMJD2A hybrid tudor domains
分子名称: JmjC domain-containing histone demethylation protein 3A, SULFATE ION
著者Lee, J, Botuyan, M.V, Mer, G.
登録日2007-07-26
公開日2007-12-11
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nat.Struct.Mol.Biol., 15, 2008
2QQS
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BU of 2qqs by Molmil
JMJD2A tandem tudor domains in complex with a trimethylated histone H4-K20 peptide
分子名称: JmjC domain-containing histone demethylation protein 3A, METHYLATED HISTONE H4 PEPTIDE
著者Lee, J, Botuyan, M.V, Mer, G.
登録日2007-07-26
公開日2007-12-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Distinct binding modes specify the recognition of methylated histones H3K4 and H4K20 by JMJD2A-tudor.
Nat.Struct.Mol.Biol., 15, 2008
3SZM
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BU of 3szm by Molmil
STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE
分子名称: Histone H2A.x, Microcephalin
著者Singh, N, Thompson, J.R, Mer, G.
登録日2011-07-19
公開日2011-11-30
最終更新日2012-09-19
実験手法X-RAY DIFFRACTION (2.63 Å)
主引用文献Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proc.Natl.Acad.Sci.USA, 109, 2012
3T1N
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BU of 3t1n by Molmil
Structure of human MICROCEPHALIN (MCPH1) TANDEM BRCT domains in complex with a CDC27 phosphopeptide
分子名称: Cdc27 peptide, Microcephalin
著者Singh, N, Thompson, J.R, Mer, G.
登録日2011-07-22
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex.
J.Biol.Chem., 287, 2012
3U3Z
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BU of 3u3z by Molmil
Structure of human microcephalin (MCPH1) tandem BRCT domains in complex with an H2A.X peptide phosphorylated at Ser139 and Tyr142
分子名称: GLYCEROL, Histone H2A.X peptide, Microcephalin
著者Singh, N, Thompson, J.R, Heroux, A, Mer, G.
登録日2011-10-06
公開日2012-07-25
最終更新日2023-12-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Proc.Natl.Acad.Sci.USA, 109, 2012
8V9U
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BU of 8v9u by Molmil
Solution NMR structure of human DNMT1 N-terminal alpha-helical domain
分子名称: DNA (cytosine-5)-methyltransferase 1
著者Hu, Q, Botuyan, M.V, Mer, G.
登録日2023-12-09
公開日2024-02-28
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献Identification of a conserved alpha-helical domain at the N terminus of human DNA methyltransferase 1.
J.Biol.Chem., 300, 2024
3L1X
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BU of 3l1x by Molmil
Crystal Structure of U-box Domain of Human E4B Ubiquitin Ligase
分子名称: Ubiquitin conjugation factor E4 B
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
3KTF
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BU of 3ktf by Molmil
Structure of the N-terminal BRCT domain of human microcephalin (MCPH1).
分子名称: CHLORIDE ION, Microcephalin
著者Singh, N, Heroux, A, Thompson, J.R, Mer, G.
登録日2009-11-25
公開日2009-12-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structure of N-terminal BRCT domain of human microcephalin (MCPH1)
To be Published
3L1Z
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Crystal structure of the U-BOX domain of human E4B ubiquitin ligase in complex with UBCH5C E2 ubiquitin conjugating enzyme
分子名称: Ubiquitin conjugation factor E4 B, Ubiquitin-conjugating enzyme E2 D3
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.17 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
3L1Y
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BU of 3l1y by Molmil
Crystal structure of human UBC4 E2 conjugating enzyme
分子名称: Ubiquitin-conjugating enzyme E2 D2
著者Benirschke, R, Thompson, J.R, Mer, G.
登録日2009-12-14
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Molecular Basis for the Association of Human E4B U Box Ubiquitin Ligase with E2-Conjugating Enzymes UbcH5c and Ubc4.
Structure, 18, 2010
6MXY
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BU of 6mxy by Molmil
Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC3351
分子名称: N-[3-(tert-butylamino)propyl]-3-(trifluoromethyl)benzamide, PHOSPHATE ION, TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.624 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXZ
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Structure of 53BP1 Tudor domains in complex with small molecule UNC3474
分子名称: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-(propan-2-yl)benzamide, TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Schuller, D.J, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MY0
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BU of 6my0 by Molmil
Structure of 53BP1 Tandem Tudor domains with E1549P and D1550N mutations
分子名称: TP53-binding protein 1
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
6MXX
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Structure of 53BP1 tandem Tudor domains in complex with small molecule UNC2991
分子名称: FORMIC ACID, N-[3-(tert-butylamino)propyl]-3-iodobenzamide, PHOSPHATE ION, ...
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2018-10-31
公開日2019-11-27
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.298 Å)
主引用文献An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering.
Nat Commun, 14, 2023
2B02
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BU of 2b02 by Molmil
Crystal Structure of ARNT PAS-B Domain
分子名称: Aryl hydrocarbon receptor nuclear translocator
著者Lee, J, Botuyan, M.V, Nomine, Y, Ohh, M, Thompson, J.R, Mer, G.
登録日2005-09-12
公開日2006-10-24
最終更新日2021-10-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal Structure and Binding Properties of ARNT PAS-B Heterodimerization Domain
To be Published
2FHD
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BU of 2fhd by Molmil
Crystal structure of Crb2 tandem tudor domains
分子名称: DNA repair protein rhp9/CRB2, PHOSPHATE ION
著者Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日2005-12-23
公開日2007-01-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Cell(Cambridge,Mass.), 127, 2006
2ETX
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BU of 2etx by Molmil
Crystal Structure of MDC1 Tandem BRCT Domains
分子名称: Mediator of DNA damage checkpoint protein 1
著者Wasielewski, E, Kim, Y, Joachimiak, A, Thompson, J.R, Mer, G.
登録日2005-10-27
公開日2005-11-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Molecular Basis for the Association of Microcephalin (MCPH1) Protein with the Cell Division Cycle Protein 27 (Cdc27) Subunit of the Anaphase-promoting Complex.
J.Biol.Chem., 287, 2012
2G3R
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BU of 2g3r by Molmil
Crystal Structure of 53BP1 tandem tudor domains at 1.2 A resolution
分子名称: SULFATE ION, Tumor suppressor p53-binding protein 1
著者Lee, J, Botuyan, M.V, Thompson, J.R, Mer, G.
登録日2006-02-20
公開日2007-01-02
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Structural Basis for the Methylation State-Specific Recognition of Histone H4-K20 by 53BP1 and Crb2 in DNA Repair.
Cell(Cambridge,Mass.), 127, 2006
7KLZ
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BU of 7klz by Molmil
Structure of SPOP MATH domain in complex with a Geminin peptide
分子名称: Geminin peptide, PHOSPHATE ION, Speckle-type POZ protein
著者Cui, G, Botuyan, M.V, Mer, G.
登録日2020-11-01
公開日2021-08-18
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition.
Nat Commun, 12, 2021
7LIP
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BU of 7lip by Molmil
X-ray structure of SPOP MATH domain (D140G)
分子名称: SULFATE ION, Speckle-type POZ protein
著者Botuyan, M.V, Cui, G, Mer, G.
登録日2021-01-27
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021
7LIO
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BU of 7lio by Molmil
X-ray structure of SPOP MATH domain (S119D) in complex with a 53BP1 peptide
分子名称: Speckle-type POZ protein, TP53-binding protein 1 peptide
著者Botuyan, M.V, Cui, G, Mer, G.
登録日2021-01-27
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.01 Å)
主引用文献ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021
7LIQ
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BU of 7liq by Molmil
X-ray structure of SPOP MATH domain (S119A)
分子名称: Speckle-type POZ protein
著者Botuyan, M.V, Cui, G, Mer, G.
登録日2021-01-27
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021
7LIN
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BU of 7lin by Molmil
X-ray structure of SPOP MATH domain (D140G) in complex with a 53BP1 peptide
分子名称: SULFATE ION, Speckle-type POZ protein, TP53-binding protein 1 peptide
著者Botuyan, M.V, Cui, G, Mer, G.
登録日2021-01-27
公開日2021-04-14
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.44 Å)
主引用文献ATM-phosphorylated SPOP contributes to 53BP1 exclusion from chromatin during DNA replication.
Sci Adv, 7, 2021
7LXD
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BU of 7lxd by Molmil
Structure of yeast DNA Polymerase Zeta (apo)
分子名称: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
著者Truong, C.D, Craig, T.A, Cui, G, Botuyan, M.V, Serkasevich, R.A, Chan, K.-Y, Mer, G, Chiu, P.-L, Kumar, R.
登録日2021-03-03
公開日2021-06-30
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.11 Å)
主引用文献Cryo-EM reveals conformational flexibility in apo DNA polymerase zeta.
J.Biol.Chem., 297, 2021
3PA6
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BU of 3pa6 by Molmil
Structure of the N-terminal BRCT domain of human microcephalin (MCPH1)
分子名称: CHLORIDE ION, Microcephalin
著者Singh, N, Heroux, A, Thompson, J.R, Mer, G.
登録日2010-10-18
公開日2010-12-08
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the N-terminal BRCT domain of human microcephalin (MCPH1)
To be Published

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