3SZM

STRUCTURE OF HUMAN MICROCEPHALIN (MCPH1) TANDEM BRCT DOMAINS IN COMPLEX WITH A GAMMA-H2AX PHOSPHOPEPTIDE

Summary for 3SZM

Entry DOI	10.2210/pdb3szm/pdb
Descriptor	Microcephalin, Histone H2A.x (3 entities in total)
Functional Keywords	dna repair, cell cycle-peptide complex, cell cycle/peptide
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm, cytoskeleton, centrosome: Q8NEM0 Nucleus: P16104
Total number of polymer chains	16
Total formula weight	185478.30
Authors	Singh, N.,Thompson, J.R.,Mer, G. (deposition date: 2011-07-19, release date: 2011-11-30, Last modification date: 2012-09-19)
Primary citation	Singh, N.,Basnet, H.,Wiltshire, T.D.,Mohammad, D.H.,Thompson, J.R.,Heroux, A.,Botuyan, M.V.,Yaffe, M.B.,Couch, F.J.,Rosenfeld, M.G.,Mer, G. Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1. Proc.Natl.Acad.Sci.USA, 109:14381-14386, 2012 Cited by PubMed: 22908299 DOI: 10.1073/pnas.1212366109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.63 Å)

Structure validation