7KLZ

Structure of SPOP MATH domain in complex with a Geminin peptide

Summary for 7KLZ

Entry DOI	10.2210/pdb7klz/pdb
Descriptor	Speckle-type POZ protein, Geminin peptide, PHOSPHATE ION (3 entities in total)
Functional Keywords	spop, geminin, math domain, e3 ubiquitin ligase, dna damage response, dna replication, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	35960.98
Authors	Cui, G.,Botuyan, M.V.,Mer, G. (deposition date: 2020-11-01, release date: 2021-08-18, Last modification date: 2023-10-18)
Primary citation	Ma, J.,Shi, Q.,Cui, G.,Sheng, H.,Botuyan, M.V.,Zhou, Y.,Yan, Y.,He, Y.,Wang, L.,Wang, Y.,Mer, G.,Ye, D.,Wang, C.,Huang, H. SPOP mutation induces replication over-firing by impairing Geminin ubiquitination and triggers replication catastrophe upon ATR inhibition. Nat Commun, 12:5779-5779, 2021 Cited by PubMed: 34599168 DOI: 10.1038/s41467-021-26049-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.4 Å)

Structure validation