1KMZ
 
 | | MOLECULAR BASIS OF MITOMYCIN C RESICTANCE IN STREPTOMYCES: CRYSTAL STRUCTURES OF THE MRD PROTEIN WITH AND WITHOUT A DRUG DERIVATIVE | | 分子名称: | mitomycin-binding protein | | 著者 | Martin, T.W, Dauter, Z, Devedjiev, Y, Sheffield, P, Jelen, F, He, M, Sherman, D, Otlewski, J, Derewenda, Z.S, Derewenda, U. | | 登録日 | 2001-12-17 | | 公開日 | 2002-07-19 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.
Structure, 10, 2002
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1KLL
 | | Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative | | 分子名称: | 1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE, mitomycin-binding protein | | 著者 | Martin, T.W, Dauter, Z, Devedjiev, Y, Sheffield, P, Jelen, F, He, M, Sherman, D, Otlewski, J, Derewenda, Z.S, Derewenda, U. | | 登録日 | 2001-12-12 | | 公開日 | 2002-07-19 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.
Structure, 10, 2002
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2A5U
 | | Crystal Structure of human PI3Kgamma complexed with AS605240 | | 分子名称: | (5E)-5-(QUINOXALIN-6-YLMETHYLENE)-1,3-THIAZOLIDINE-2,4-DIONE, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | | 著者 | Camps, M, Ruckle, T, Ji, H, Ardissone, V, Rintelen, F, Shaw, J, Ferrandi, C, Chabert, C, Gillieron, C, Francon, B, Martin, T, Gretener, D, Perrin, D, Leroy, D, Vitte, P.-A, Hirsch, E, Wymann, M.P, Cirillo, R, Schwarz, M.K, Rommel, C. | | 登録日 | 2005-07-01 | | 公開日 | 2005-09-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
NAT.MED. (N.Y.), 11, 2005
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3ZIM
 | | Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha | | 分子名称: | 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | | 著者 | Nacht, M, Qiao, L, Sheets, M.P, Martin, T.S, Labenski, M, Mazdiyasni, H, Karp, R, Zhu, Z, Chaturvedi, P, Bhavsar, D, Niu, D, Westlin, W, Petter, R.C, Medikonda, A.P, Jestel, A, Blaesse, M, Singh, J. | | 登録日 | 2013-01-09 | | 公開日 | 2013-02-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase Pi3Kalpha
J.Med.Chem., 56, 2013
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3OYP
 | | HCV NS3/4A in complex with ligand 3 | | 分子名称: | Non-structural protein 4A, Peptidomimetic inhibitor, Serine protease NS3, ... | | 著者 | Hagel, M, Niu, D, St.Martin, T, Sheets, M.P, Qiao, L, Bernard, H, Karp, R.M, Zhu, Z, Labenski, M.T, Chaturvedi, P.C, Nacht, M, Westlin, W.F, Petter, R.C, Singh, J. | | 登録日 | 2010-09-23 | | 公開日 | 2010-12-01 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.76 Å) | | 主引用文献 | Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
Nat.Chem.Biol., 7, 2011
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5YBA
 | | Dimeric Cyclophilin from T.vaginalis in complex with Myb1 peptide | | 分子名称: | Myb1 peptide, Peptidyl-prolyl cis-trans isomerase | | 著者 | Cho, C.C, Lin, M.H, Martin, T, Chou, C.C, Chen, C, Hsu, C.H. | | 登録日 | 2017-09-04 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.062 Å) | | 主引用文献 | Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis
Sci Rep, 8, 2018
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5YB9
 | | Crystal structure of a dimeric cyclophilin A from T.vaginalis | | 分子名称: | Peptidyl-prolyl cis-trans isomerase | | 著者 | Cho, C.C, Lin, M.H, Chou, C.C, Martin, T, Chen, C, Hsu, C.H. | | 登録日 | 2017-09-04 | | 公開日 | 2018-07-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.276 Å) | | 主引用文献 | Structural basis of interaction between dimeric cyclophilin 1 and Myb1 transcription factor in Trichomonas vaginalis
Sci Rep, 8, 2018
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7ARE
 | | DNA origami pointer object v2 | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Thomas, M, Feigl, E, Kohler, F, Kube, M, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-24 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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7ART
 | | 48 helix bundle DNA origami brick | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Feigl, E, Kube, M, Kohler, F, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-26 | | 公開日 | 2020-11-11 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (10 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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7AS5
 | | 126 helix bundle DNA nanostructure | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-27 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (9.8 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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7ARV
 | | TwistTower_native-twist | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-26 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (7.4 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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7ARY
 | | Twist-Tower_twist-corrected-variant | | 分子名称: | SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Kube, M, Kohler, F, Feigl, E, Nagel-Yuksel, B, Willner, E.M, Funke, J.J, Gerling, T, Stommer, P, Honemann, M.N, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2020-10-26 | | 公開日 | 2020-11-18 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | | 主引用文献 | Revealing the structures of megadalton-scale DNA complexes with nucleotide resolution.
Nat Commun, 11, 2020
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4V5X
 | | The cryo-EM structure of a 3D DNA-origami object | | 分子名称: | SCAFFOLD STRAND,SCAFFOLD STRAND, STAPLE STRAND | | 著者 | Bai, X.C, Martin, T.G, Scheres, S.H.W, Dietz, H. | | 登録日 | 2012-10-09 | | 公開日 | 2014-07-09 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (11.5 Å) | | 主引用文献 | Cryo-Em Structure of a 3D DNA-Origami Object.
Proc.Natl.Acad.Sci.USA, 109, 2012
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2A4Z
 | | Crystal Structure of human PI3Kgamma complexed with AS604850 | | 分子名称: | (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | | 著者 | Camps, M, Ruckle, T, Ji, H, Ardissone, V, Rintelen, F, Shaw, J, Ferrandi, C, Chabert, C, Gillieron, C, Francon, B, Martin, T, Gretener, D, Perrin, D, Leroy, D, Vitte, P.-A, Hirsch, E, Wymann, M.P, Cirillo, R, Schwarz, M.K, Rommel, C. | | 登録日 | 2005-06-30 | | 公開日 | 2005-09-20 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis
NAT.MED. (N.Y.), 11, 2005
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3FFD
 | | Structure of parathyroid hormone-related protein complexed to a neutralizing monoclonal antibody | | 分子名称: | Monoclonal antibody, heavy chain, Fab fragment, ... | | 著者 | Mckinstry, W.J, Polekhina, G, Diefenbach-Jagger, H, Ho, P.W.M, Sato, K, Onuma, E, Gillespie, M.T, Martin, T.J, Parker, M.W. | | 登録日 | 2008-12-03 | | 公開日 | 2009-04-28 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural basis for antibody discrimination between two hormones that recognize the parathyroid hormone receptor
J.Biol.Chem., 284, 2009
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5MZ6
 | | Cryo-EM structure of a Separase-Securin complex from Caenorhabditis elegans at 3.8 A resolution | | 分子名称: | Interactor of FizzY protein, SEParase | | 著者 | Boland, A, Martin, T.G, Zhang, Z, Yang, J, Bai, X.C, Chang, L, Scheres, S.H.W, Barford, D. | | 登録日 | 2017-01-31 | | 公開日 | 2017-03-08 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Cryo-EM structure of a metazoan separase-securin complex at near-atomic resolution.
Nat. Struct. Mol. Biol., 24, 2017
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5GAQ
 | | Cryo-EM structure of the Lysenin Pore | | 分子名称: | Lysenin | | 著者 | Savva, C.G, Bokori-Brown, M, Martin, T.G, Titball, R.W, Naylor, C.E, Basak, A.K. | | 登録日 | 2016-01-05 | | 公開日 | 2016-04-06 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Cryo-EM structure of lysenin pore elucidates membrane insertion by an aerolysin family protein
Nat Commun, 7, 2016
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1ES9
 | | X-RAY CRYSTAL STRUCTURE OF R22K MUTANT OF THE MAMMALIAN BRAIN PLATELET-ACTIVATING FACTOR ACETYLHYDROLASES (PAF-AH) | | 分子名称: | PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE IB GAMMA SUBUNIT | | 著者 | McMullen, T.W.P, Li, J, Sheffield, P.J, Aoki, J, Martin, T.W, Arai, H, Inoue, K, Derewenda, Z.S. | | 登録日 | 2000-04-07 | | 公開日 | 2000-05-31 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | The functional implications of the dimerization of the catalytic subunits of the mammalian brain platelet-activating factor acetylhydrolase (Ib).
Protein Eng., 13, 2000
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6MHN
 | | Photoactive Yellow Protein with covalently bound 3-chloro-4-hydroxycinnamic acid chromophore | | 分子名称: | (2E)-3-(3-chloro-4-hydroxyphenyl)prop-2-enoic acid, Photoactive yellow protein | | 著者 | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | | 登録日 | 2018-09-18 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation.
J.Phys.Chem.B, 123, 2019
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6MHI
 | | Photoactive Yellow Protein with covalently bound 3,5-dichloro-4-hydroxycinnamic acid chromophore | | 分子名称: | (2E)-3-(3,5-dichloro-4-hydroxyphenyl)prop-2-enoic acid, Photoactive yellow protein | | 著者 | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | | 登録日 | 2018-09-18 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation.
J.Phys.Chem.B, 123, 2019
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6MKT
 | | Photoactive Yellow Protein with 3-chlorotyrosine substituted at position 42 | | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | | 著者 | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | | 登録日 | 2018-09-26 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation.
J.Phys.Chem.B, 123, 2019
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6MMD
 | | Photoactive Yellow Protein with 3,5-dichlorotyrosine substituted at position 42 | | 分子名称: | 4'-HYDROXYCINNAMIC ACID, Photoactive yellow protein | | 著者 | Thomson, B.D, Both, J, Wu, Y, Parrish, R.M, Martinez, T, Boxer, S.G. | | 登録日 | 2018-09-30 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.228 Å) | | 主引用文献 | Perturbation of Short Hydrogen Bonds in Photoactive Yellow Protein via Noncanonical Amino Acid Incorporation.
J.Phys.Chem.B, 123, 2019
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5LZH
 | | Cholera toxin classical B-pentamer in complex with inhibitor PC262 | | 分子名称: | (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Heggelund, J.E, Martinsen, T, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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5LZG
 | | Cholera toxin El Tor B-pentamer in complex with inhibitor PC262 | | 分子名称: | (2~{R},4~{S},5~{R},6~{R})-5-acetamido-2-[4-[3-[2-[(2~{S},3~{R},4~{R},5~{R},6~{R})-6-(hydroxymethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]ethylamino]-3-oxidanylidene-propyl]-1,2,3-triazol-1-yl]-4-oxidanyl-6-[(1~{R},2~{R})-1,2,3-tris(oxidanyl)propyl]oxane-2-carboxylic acid, (4R)-2-METHYLPENTANE-2,4-DIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | | 著者 | Heggelund, J.E, Martinsen, T, Krengel, U. | | 登録日 | 2016-09-29 | | 公開日 | 2017-05-31 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics.
Sci Rep, 7, 2017
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7MRJ
 | | Crystal structure of a novel ubiquitin-like TINCR | | 分子名称: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | | 著者 | Forouhar, F, Morgado-Palacin, L, Brown, J.A, Martinez, T, Pedrero, J.M.G, Reglero, C, Chaudhry, I, Vaughan, J, Rodriguez-Perales, S, Allonca, E, Granda-Diaz, R, Quinn, S.A, Fernandez, A.F, Fraga, M.F, Kim, A.L, Santos-Juanes, J, Owens, D.M, Rodrigo, J.P, Saghatelian, A, Ferrando, A.A. | | 登録日 | 2021-05-07 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma.
Nat Commun, 14, 2023
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