3ZIM
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha
Summary for 3ZIM
Entry DOI | 10.2210/pdb3zim/pdb |
Descriptor | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione (3 entities in total) |
Functional Keywords | transferase |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 109980.19 |
Authors | Nacht, M.,Qiao, L.,Sheets, M.P.,Martin, T.S.,Labenski, M.,Mazdiyasni, H.,Karp, R.,Zhu, Z.,Chaturvedi, P.,Bhavsar, D.,Niu, D.,Westlin, W.,Petter, R.C.,Medikonda, A.P.,Jestel, A.,Blaesse, M.,Singh, J. (deposition date: 2013-01-09, release date: 2013-02-13, Last modification date: 2024-05-01) |
Primary citation | Nacht, M.,Qiao, L.,Sheets, M.P.,Martin, T.S.,Labenski, M.,Mazdiyasni, H.,Karp, R.,Zhu, Z.,Chaturvedi, P.,Bhavsar, D.,Niu, D.,Westlin, W.,Petter, R.C.,Medikonda, A.P.,Singh, J. Discovery of a Potent and Isoform-Selective Targeted Covalent Inhibitor of the Lipid Kinase Pi3Kalpha J.Med.Chem., 56:712-, 2013 Cited by PubMed: 23360348DOI: 10.1021/JM3008745 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.85 Å) |
Structure validation
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