3ZIM
Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kalpha
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM | polymer | 940 | 109406.5 | 1 | UniProt (P42336) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | HOMO SAPIENS (HUMAN) | PI3-KINASE SUBUNIT ALPHA, PI3K-ALPHA, PI3KALPHA, PTDINS-3-KINASE SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE 110 KDA CATALYTIC SUBUNIT ALPHA, PTDINS-3-KINASE SUBUNIT P110-ALPHA, P110ALPHA, PHOSPHOINOSITIDE-3-KINASE CATALYTIC ALPHA POLYPEPTIDE, SERINE/THREONINE PROTEIN KINASE PIK3CA |
| 2 | A | 1-[4-[[2-(1H-indazol-4-yl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-6-methyl-hept-5-ene-1,4- dione | non-polymer | 573.7 | 1 | Chemie (KKR) | |||
| 3 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109406.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 573.7 | |
| All* | Total formula weight | 109980.2 |
