2A4Z

Crystal Structure of human PI3Kgamma complexed with AS604850

Summary for 2A4Z

Entry DOI	10.2210/pdb2a4z/pdb
Related	1e7u 1e7v 1e8w 1e8x 1e8y 2A5U
Descriptor	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform, (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE (3 entities in total)
Functional Keywords	protein-inhibitor complex, pi3kg, transferase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P48736
Total number of polymer chains	1
Total formula weight	111041.39
Authors	Camps, M.,Ruckle, T.,Ji, H.,Ardissone, V.,Rintelen, F.,Shaw, J.,Ferrandi, C.,Chabert, C.,Gillieron, C.,Francon, B.,Martin, T.,Gretener, D.,Perrin, D.,Leroy, D.,Vitte, P.-A.,Hirsch, E.,Wymann, M.P.,Cirillo, R.,Schwarz, M.K.,Rommel, C. (deposition date: 2005-06-30, release date: 2005-09-20, Last modification date: 2023-10-25)
Primary citation	Camps, M.,Ruckle, T.,Ji, H.,Ardissone, V.,Rintelen, F.,Shaw, J.,Ferrandi, C.,Chabert, C.,Gillieron, C.,Francon, B.,Martin, T.,Gretener, D.,Perrin, D.,Leroy, D.,Vitte, P.-A.,Hirsch, E.,Wymann, M.P.,Cirillo, R.,Schwarz, M.K.,Rommel, C. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis NAT.MED. (N.Y.), 11:936-943, 2005 Cited by PubMed: 16127437 DOI: 10.1038/nm1284 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation