1E7V

Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

Summary for 1E7V

Entry DOI	10.2210/pdb1e7v/pdb
Descriptor	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE (3 entities in total)
Functional Keywords	transferase, secondary messenger generation pi3k, pi 3k, ly294002
Biological source	SUS SCROFA (WILD BOAR)
Total number of polymer chains	1
Total formula weight	110259.90
Authors	Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Wymann, M.P.,Williams, R.L. (deposition date: 2000-09-08, release date: 2000-11-17, Last modification date: 2023-12-13)
Primary citation	Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Wymann, M.P.,Williams, R.L. Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine. Mol.Cell, 6:909-919, 2000 Cited by PubMed: 11090628 DOI: 10.1016/s1097-2765(05)00089-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation