1E7V
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT | polymer | 961 | 109952.6 | 1 | UniProt (O02697) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | SUS SCROFA (WILD BOAR) | PTDINS-3-KINASE P110, PI3K |
| 2 | B (A) | 2-MORPHOLIN-4-YL-7-PHENYL-4H-CHROMEN-4-ONE | non-polymer | 307.3 | 1 | Chemie (LY2) | |||
| 3 | C (A) | water | water | 18.0 | 135 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: O02697)
| PDB | External Database | Details |
|---|---|---|
| Ala 142 | - | expression tag |
| Ala 143 | - | expression tag |
| Ala 505 | Arg 505 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109952.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 307.3 | |
| All* | Total formula weight | 110259.9 |
