1E7U

Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine

Summary for 1E7U

Entry DOI	10.2210/pdb1e7u/pdb
Descriptor	PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT, (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE (3 entities in total)
Functional Keywords	phosphoinositide 3-kinase gamma, secondary messenger generation, pi3k, pi 3k, wortmannin
Biological source	SUS SCROFA (WILD BOAR)
Total number of polymer chains	1
Total formula weight	110380.99
Authors	Walker, E.H.,Perisic, O.,Ried, C.,Stephens, L.,Williams, R.L. (deposition date: 2000-09-08, release date: 2000-11-17, Last modification date: 2023-12-13)
Primary citation	Walker, E.H.,Pacold, M.E.,Perisic, O.,Stephens, L.,Hawkins, P.T.,Whymann, M.P.,Williams, R.L. Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine Mol.Cell, 6:909-, 2000 Cited by PubMed: 11090628 DOI: 10.1016/S1097-2765(05)00089-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation