1E7U
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT | polymer | 961 | 109952.6 | 1 | UniProt (O02697) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | SUS SCROFA (WILD BOAR) | PTDINS-3-KINASE P110, PI3K, PI 3K |
| 2 | B (A) | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | non-polymer | 428.4 | 1 | Chemie (KWT) PubChem (5691) PubChem (44155625) PubChem (44283298) PubChem (44388158) PubChem (363060) PubChem (70846633) PubChem (71094029) PubChem (73897916) PubChem (58919665) PubChem (71109225) PubChem (3003565) PubChem (312145) PubChem (124543094) PubChem (124583470) PubChem (95566344) PubChem (6604048) PubChem (6604834) PubChem (6713132) PubChem (142863033) PubChem (125039846) PubChem (125039847) PubChem (162901955) PubChem (129010046) PubChem (129010429) PubChem (134688220) PubChem (162901956) PubChem (162901957) PubChem (162901958) | |||
| 3 | C (A) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 142 - 1102 (UniProt: O02697)
| PDB | External Database | Details |
|---|---|---|
| Ala 143 | Pro 143 | expression tag |
| Ala 505 | Arg 505 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109952.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 428.4 | |
| All* | Total formula weight | 110381.0 |
