1E7U
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT | polymer | 961 | 109952.6 | 1 | UniProt (O02697) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) | SUS SCROFA (WILD BOAR) | PTDINS-3-KINASE P110, PI3K, PI 3K |
| 2 | B (A) | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE | non-polymer | 428.4 | 1 | Chemie (KWT) | |||
| 3 | C (A) | water | water | 18.0 | 164 | Chemie (HOH) |
Sequence modifications
A: 142 - 1102 (UniProt: O02697)
| PDB | External Database | Details |
|---|---|---|
| Ala 143 | Pro 143 | expression tag |
| Ala 505 | Arg 505 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 109952.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 428.4 | |
| All* | Total formula weight | 110381.0 |
