2A4Z
Crystal Structure of human PI3Kgamma complexed with AS604850
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, gamma isoform | polymer | 966 | 110756.2 | 1 | UniProt (P48736) Pfam (PF00794) Pfam (PF00792) Pfam (PF00613) Pfam (PF00454) In PDB | Homo sapiens (human) | phosphatidylinositol 3-kinase catalytic subunit, PI3-kinase p110 subunit gamma, PtdIns- 3-kinase p110, PI3K, PI3Kgamma |
| 2 | A | (5E)-5-[(2,2-DIFLUORO-1,3-BENZODIOXOL-5-YL)METHYLENE]-1,3-THIAZOLIDINE-2,4-DIONE | non-polymer | 285.2 | 1 | Chemie (BYM) | |||
| 3 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 144 - 1102 (UniProt: P48736)
| PDB | External Database | Details |
|---|---|---|
| Met 143 | - | initiating methionine |
| His 1103 | - | expression tag |
| His 1104 | - | expression tag |
| His 1105 | - | expression tag |
| His 1106 | - | expression tag |
| His 1107 | - | expression tag |
| His 1108 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 110756.2 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 285.2 | |
| All* | Total formula weight | 111041.4 |
