1KLL

Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative

Summary for 1KLL

Related1KMZ
Descriptormitomycin-binding protein, 1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE (3 entities in total)
Functional Keywordsmitomycin c, antibiotic resistance, sad, anomalous diffraction, domain swapping, p-staking, antimicrobial protein
Biological sourceStreptomyces lavendulae
Total number of polymer chains1
Total molecular weight14892.19
Authors
Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U. (deposition date: 2001-12-12, release date: 2002-07-19, Last modification date: 2011-07-13)
Primary citation
Martin, T.W.,Dauter, Z.,Devedjiev, Y.,Sheffield, P.,Jelen, F.,He, M.,Sherman, D.H.,Otlewski, J.,Derewenda, Z.S.,Derewenda, U.
Molecular basis of mitomycin C resistance in streptomyces: structure and function of the MRD protein.
Structure, 10:933-942, 2002
PubMed: 12121648 (PDB entries with the same primary citation)
DOI: 10.1016/S0969-2126(02)00778-5
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.5 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRSRZ outliers806.9%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload