1KLL
Molecular basis of mitomycin C resictance in streptomyces: Crystal structures of the MRD protein with and without a drug derivative
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | mitomycin-binding protein | polymer | 130 | 14571.9 | 1 | UniProt (O05205) Pfam (PF00903) | Streptomyces lavendulae | Mrd; Mitomycin resistance protein D |
| 2 | B (A) | 1,2-CIS-1-HYDROXY-2,7-DIAMINO-MITOSENE | non-polymer | 320.3 | 1 | Chemie (MC) | |||
| 3 | C (A) | water | water | 18.0 | 153 | Chemie (HOH) |
Sequence modifications
A: 1 - 130 (UniProt: O05205)
| PDB | External Database | Details |
|---|---|---|
| Mse 15 | Met 15 | cloning artifact |
| Mse 19 | Leu 19 | engineered mutation |
| Mse 25 | Leu 25 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 14571.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 320.3 | |
| All* | Total formula weight | 14892.2 |
