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PDB: 43 件
4INI
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BU of 4ini by Molmil
Human Histidine Triad Nucleotide Binding Protein 2 with Bound AMP
分子名称: 1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
著者Maize, K.M, Wagner, C.R, Finzel, B.C.
登録日2013-01-04
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.
Febs J., 280, 2013
4INC
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BU of 4inc by Molmil
Human Histidine Triad Nucleotide Binding Protein 2
分子名称: CHLORIDE ION, Histidine triad nucleotide-binding protein 2, mitochondrial
著者Maize, K.M, Wagner, C.R, Finzel, B.C.
登録日2013-01-04
公開日2013-05-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.19 Å)
主引用文献Structural characterization of human histidine triad nucleotide-binding protein 2, a member of the histidine triad superfamily.
Febs J., 280, 2013
5EMT
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BU of 5emt by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-copper complex
分子名称: COPPER (II) ION, Histidine triad nucleotide-binding protein 1
著者Maize, K.M, Nix, J.C, Finzel, B.C.
登録日2015-11-06
公開日2016-11-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Inhibition by divalent metal ions of human histidine triad nucleotide binding protein1 (hHint1), a regulator of opioid analgesia and neuropathic pain.
Biochem. Biophys. Res. Commun., 491, 2017
4WF6
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BU of 4wf6 by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor MK-31
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ...
著者Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
登録日2014-09-12
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.6521 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
4XM8
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BU of 4xm8 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: Lethal factor, N-hydroxy-N~2~-{[3-(methoxymethyl)phenyl]sulfonyl}-N~2~-(2-methylpropyl)-D-valinamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM6
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BU of 4xm6 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
著者Maize, K.M, De la Mora-Rey, T, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
4XM7
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BU of 4xm7 by Molmil
Anthrax toxin lethal factor with ligand-induced binding pocket
分子名称: 1,2-ETHANEDIOL, Lethal factor, N~2~-[(4-fluoro-3-methoxyphenyl)sulfonyl]-N-hydroxy-N~2~-(2-methylpropyl)-D-valinamide, ...
著者Maize, K.M, Finzel, B.C.
登録日2015-01-14
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor.
Febs Lett., 589, 2015
5D1S
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BU of 5d1s by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-methyl-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5D1U
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BU of 5d1u by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-(6-aminohexyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8503 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5KMC
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BU of 5kmc by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) non-nucleotidic covalent intermediate complex
分子名称: Histidine triad nucleotide-binding protein 1, [2-(1~{H}-indol-3-yl)ethylamino]phosphonic acid
著者Maize, K.M, Finzel, B.C.
登録日2016-06-26
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Structural Biology for Drug Design: Applications in Two Systems
THESIS, University of Minnesota Digital Conservancy, 2016
5TE2
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BU of 5te2 by Molmil
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a mechanism-based inhibitor
分子名称: 1,2-ETHANEDIOL, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, DI(HYDROXYETHYL)ETHER, ...
著者Maize, K.M, Eiden, C, Aldrich, C.C, Finzel, B.C.
登録日2016-09-20
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.
J. Am. Chem. Soc., 139, 2017
4PKS
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BU of 4pks by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 11
分子名称: 1,2-ETHANEDIOL, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKR
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BU of 4pkr by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 10
分子名称: CHLORIDE ION, GLYCEROL, Lethal factor, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKU
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BU of 4pku by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 15
分子名称: Lethal factor, N~2~-(3-aminobenzyl)-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKW
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BU of 4pkw by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor GM6001
分子名称: 1,2-ETHANEDIOL, 3-(N-HYDROXYCARBOXAMIDO)-2-ISOBUTYLPROPANOYL-TRP-METHYLAMIDE, GLYCEROL, ...
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKQ
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BU of 4pkq by Molmil
Anthrax toxin lethal factor with bound zinc
分子名称: 1,2-ETHANEDIOL, Lethal factor, TRIETHYLENE GLYCOL, ...
著者Maize, K.M, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKV
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BU of 4pkv by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 16
分子名称: Lethal factor, N~2~-[4-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
4PKT
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BU of 4pkt by Molmil
Anthrax toxin lethal factor with bound small molecule inhibitor 13
分子名称: Lethal factor, N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-N~2~-(4-nitrobenzyl)-D-alaninamide, ZINC ION
著者Maize, K.M, De la Mora, T, Finzel, B.C.
登録日2014-05-15
公開日2014-11-12
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.
Acta Crystallogr.,Sect.D, 70, 2014
5KGT
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BU of 5kgt by Molmil
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead: 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone
分子名称: 1-[4-[4-(3-chlorophenyl)carbonylpiperidin-1-yl]phenyl]ethanone, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE
著者Maize, K.M, Divakaran, A, Aldrich, C.C, Finzel, B.C.
登録日2016-06-13
公開日2017-06-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
J. Med. Chem., 60, 2017
5KGS
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BU of 5kgs by Molmil
Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with an inhibitor optimized from HTS lead: 5-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]-2,3-dihydroinden-1-one
分子名称: 5-[4-(1,3-benzodioxol-5-ylcarbonyl)piperazin-1-yl]-2,3-dihydroinden-1-one, Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, PYRIDOXAL-5'-PHOSPHATE, ...
著者Maize, K.M, Aldrich, C.C, Finzel, B.C.
登録日2016-06-13
公開日2017-06-14
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure-Based Optimization of Pyridoxal 5'-Phosphate-Dependent Transaminase Enzyme (BioA) Inhibitors that Target Biotin Biosynthesis in Mycobacterium tuberculosis.
J. Med. Chem., 60, 2017
5KM4
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BU of 5km4 by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1)-5-Iodo-UMP complex
分子名称: 5-IODOURIDINE-5'-MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1
著者Maize, K.M, Finzel, B.C.
登録日2016-06-26
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14, 2017
5KLZ
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BU of 5klz by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) AMP catalytic product complex
分子名称: 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, Histidine triad nucleotide-binding protein 1
著者Maize, K.M, Finzel, B.C.
登録日2016-06-26
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14, 2017
5KM5
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BU of 5km5 by Molmil
Human Histidine Triad Nucleotide Binding Protein 2 (hHint2) triciribine 5'-monoposphate catalytic product complex
分子名称: 5-methyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1,5-dihydro-1,4,5,6,8-pentaazaacenaphthylen-3-amine, CHLORIDE ION, Histidine triad nucleotide-binding protein 2, ...
著者Maize, K.M, Finzel, B.C.
登録日2016-06-26
公開日2017-06-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14, 2017
5D1T
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BU of 5d1t by Molmil
Anthrax toxin lethal factor with hydroxamic acid inhibitor
分子名称: Lethal factor, N~2~-[3-(aminomethyl)benzyl]-N~2~-[(4-fluoro-3-methylphenyl)sulfonyl]-N-hydroxy-D-alaninamide, ZINC ION
著者Maize, K.M, Finzel, B.C.
登録日2015-08-04
公開日2015-11-11
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.
J.Med.Chem., 58, 2015
5WA9
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BU of 5wa9 by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) H112N mutant nucleoside D-Ala phosphoramidate substrate complex
分子名称: CHLORIDE ION, Histidine triad nucleotide-binding protein 1, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-~{N}-[(2~{R})-1-methoxy-1-oxidanylidene-propan-2-yl]phosphonamidic acid
著者Maize, K.M, Finzel, B.C.
登録日2017-06-26
公開日2017-10-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献A Crystal Structure Based Guide to the Design of Human Histidine Triad Nucleotide Binding Protein 1 (hHint1) Activated ProTides.
Mol. Pharm., 14, 2017

 

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