5TE2

Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a mechanism-based inhibitor

Summary for 5TE2

• Entry DOI: 10.2210/pdb5te2/pdb
• Related: 3TFT 3TFU 4CXQ
• Descriptor: Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, [5-hydroxy-4-({[6-(3-hydroxypropyl)-4-oxo-1,4-dihydropyridin-3-yl]amino}methyl)-6-methylpyridin-3-yl]methyl dihydrogen phosphate, DI(HYDROXYETHYL)ETHER, ... (6 entities in total)
• Functional Keywords: inhibitor complex, transaminase, plp, transferase, transferase-inhibitor complex, mechanism-based inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)
• Total number of polymer chains: 2
• Total formula weight: 98190.07

Authors

Maize, K.M.,Eiden, C.,Aldrich, C.C.,Finzel, B.C. (deposition date: 2016-09-20, release date: 2017-05-31, Last modification date: 2023-10-04)

• Primary citation: Eiden, C.G.,Maize, K.M.,Finzel, B.C.,Lipscomb, J.D.,Aldrich, C.C.; Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation.; J. Am. Chem. Soc., 139:7132-7135, 2017; PubMed: 28510452; DOI: 10.1021/jacs.7b00962

Experimental method

X-RAY DIFFRACTION (1.8 Å)