6H6E
 
 | | PTC3 holotoxin complex from Photorhabdus luminecens in prepore state (TcdA1, TcdB2, TccC3) | | 分子名称: | TcdA1, TcdB2,TccC3 | | 著者 | Gatsogiannis, C, Merino, F, Roderer, D, Balchin, D, Schubert, E, Kuhlee, A, Hayer-Hartl, M, Raunser, S. | | 登録日 | 2018-07-27 | | 公開日 | 2018-10-03 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (3.95 Å) | | 主引用文献 | Tc toxin activation requires unfolding and refolding of a beta-propeller.
Nature, 563, 2018
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6H3S
 | | Schmallenberg Virus Glycoprotein Gc Head/Stalk Domains | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Envelopment polyprotein, ... | | 著者 | Hellert, J, Aebischer, A, Wernike, K, Haouz, A, Brocchi, E, Reiche, S, Guardado-Calvo, P, Beer, M, Rey, F.A. | | 登録日 | 2018-07-19 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.023 Å) | | 主引用文献 | Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
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6H3X
 | | Oropouche Virus Glycoprotein Gc Head Domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Polyprotein, ... | | 著者 | Hellert, J, Aebischer, A, Wernike, K, Haouz, A, Brocchi, E, Reiche, S, Guardado-Calvo, P, Beer, M, Rey, F.A. | | 登録日 | 2018-07-19 | | 公開日 | 2019-02-27 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.092 Å) | | 主引用文献 | Orthobunyavirus spike architecture and recognition by neutralizing antibodies.
Nat Commun, 10, 2019
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6H4G
 | | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, Protein kinase A regulatory subunit | | 著者 | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | | 登録日 | 2018-07-21 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.143517 Å) | | 主引用文献 | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
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6H54
 | | CRYSTAL STRUCTURE OF BOVINE HSC70(AA1-554)E213A/D214A IN COMPLEX WITH INHIBITOR VER155008 | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile, GLYCEROL, ... | | 著者 | Plank, C, Zehe, M, Grimm, C, Sotriffer, C. | | 登録日 | 2018-07-23 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | | 主引用文献 | Combined In-Solution Fragment Screening and Crystallographic Binding-Mode Analysis with a Two-Domain Hsp70 Construct.
Acs Chem.Biol., 2024
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6H59
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6O3B
 | | Crystal structure of Frizzled 7 CRD in complex with F6 Fab | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Fab F6, Heavy chain, ... | | 著者 | Raman, S, Beilschmidt, M, Fransson, J, Julien, J.P. | | 登録日 | 2019-02-26 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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6H76
 | | SiaP in complex with Neu5Ac (RT) | | 分子名称: | CESIUM ION, CHLORIDE ION, N-acetyl-beta-neuraminic acid, ... | | 著者 | Fischer, M, Darby, J.F, Brannigan, J.A, Turkenburg, J, Hubbard, R.E. | | 登録日 | 2018-07-30 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-05-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Water Networks Can Determine the Affinity of Ligand Binding to Proteins.
J.Am.Chem.Soc., 141, 2019
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3RB7
 | | Crystal structure of CBD12 from CALX1.2 | | 分子名称: | CALCIUM ION, Na/Ca exchange protein, SULFATE ION | | 著者 | Wu, M, Zheng, L. | | 登録日 | 2011-03-28 | | 公開日 | 2011-11-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural Basis of the Ca(2+) Inhibitory Mechanism of Drosophila Na(+)/Ca(2+) Exchanger CALX and Its Modification by Alternative Splicing.
Structure, 19, 2011
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6H7P
 | | Reductive Aminase from Aspergillus terreus in complex with NADPH4, cyclohexanone and allyl amine | | 分子名称: | CYCLOHEXANONE, Reductive Aminase, [[(2~{R},3~{S},4~{R},5~{R})-5-[(3~{R})-3-aminocarbonylpiperidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{R},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3-oxidanyl-4-phosphonooxy-oxolan-2-yl]methyl hydrogen phosphate, ... | | 著者 | Sharma, M, Grogan, G, Mangas-Sanchez, J, Turner, N.J. | | 登録日 | 2018-07-31 | | 公開日 | 2019-04-03 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structure of Reductive Aminase from Aspergillus terreus
Acs Catalysis, 2018
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6GF2
 | | The structure of the ubiquitin-like modifier FAT10 reveals a novel targeting mechanism for degradation by the 26S proteasome | | 分子名称: | Ubiquitin D | | 著者 | Aichem, A, Anders, S, Catone, N, Roessler, P, Stotz, S, Berg, A, Schwab, R, Scheuermann, S, Bialas, J, Schmidtke, G, Peter, C, Groettrup, M, Wiesner, S. | | 登録日 | 2018-04-29 | | 公開日 | 2018-08-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The structure of the ubiquitin-like modifier FAT10 reveals an alternative targeting mechanism for proteasomal degradation.
Nat Commun, 9, 2018
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3OM2
 | | Crystal structure of B. megaterium levansucrase mutant D257A | | 分子名称: | CALCIUM ION, CITRIC ACID, Levansucrase, ... | | 著者 | Strube, C.P, Homann, A, Gamer, M, Jahn, D, Seibel, J, Heinz, D.W. | | 登録日 | 2010-08-26 | | 公開日 | 2011-03-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Polysaccharide Synthesis of the Levansucrase SacB from Bacillus megaterium Is Controlled by Distinct Surface Motifs.
J.Biol.Chem., 286, 2011
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3P8F
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3P9U
 | | Crystal structure of TetX2 from Bacteroides thetaiotaomicron with substrate analogue | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, TetX2 protein | | 著者 | Walkiewicz, K, Davlieva, M, Sun, C, Lau, K, Shamoo, Y. | | 登録日 | 2010-10-18 | | 公開日 | 2011-04-27 | | 最終更新日 | 2017-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | Crystal structure of Bacteroides thetaiotaomicron TetX2: a tetracycline degrading monooxygenase at 2.8 A resolution.
Proteins, 79, 2011
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6HB8
 | | Crystal structure of OXA-517 beta-lactamase | | 分子名称: | 1,2-ETHANEDIOL, 2-ETHOXYETHANOL, Beta-lactamase, ... | | 著者 | Raczynska, J.E, Dabos, L, Zavala, A, Retailleau, P, Iorga, B, Jaskolski, M, Naas, T. | | 登録日 | 2018-08-09 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | | 主引用文献 | Genetic, biochemical and structural characterization of OXA-517, an OXA-48-like extended-spectrum cephalosporins and carbapenems-hydrolyzing beta-lactamase
To Be Published
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3PB1
 | | Crystal Structure of a Michaelis Complex between Plasminogen Activator Inhibitor-1 and Urokinase-type Plasminogen Activator | | 分子名称: | Plasminogen activator inhibitor 1, Plasminogen activator, urokinase, ... | | 著者 | Lin, Z, Jiang, L, Huang, M, Structure 2 Function Project (S2F) | | 登録日 | 2010-10-20 | | 公開日 | 2010-12-29 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.
J.Biol.Chem., 286, 2011
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6K7I
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1-ATP state class2) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | 著者 | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2019-06-07 | | 公開日 | 2019-08-28 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | | 主引用文献 | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
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3OM5
 | | Crystal structure of B. megaterium levansucrase mutant N252A | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, ... | | 著者 | Strube, C.P, Homann, A, Gamer, M, Jahn, D, Seibel, J, Heinz, D.W. | | 登録日 | 2010-08-26 | | 公開日 | 2011-03-23 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Polysaccharide Synthesis of the Levansucrase SacB from Bacillus megaterium Is Controlled by Distinct Surface Motifs.
J.Biol.Chem., 286, 2011
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6JYE
 | | Structure of dark-state marine bacterial chloride importer, NM-R3, with Pulse laser (ND-1%) at 140K. | | 分子名称: | CHLORIDE ION, Chloride pumping rhodopsin, OLEIC ACID, ... | | 著者 | Yun, J.H, Ohki, M, Park, S.Y, Lee, W. | | 登録日 | 2019-04-26 | | 公開日 | 2020-03-04 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Pumping mechanism of NM-R3, a light-driven bacterial chloride importer in the rhodopsin family.
Sci Adv, 6, 2020
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3P7Q
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6NIU
 | | Crystal structure of a human anti-ZIKV-DENV neutralizing antibody MZ4 in complex with ZIKV E glycoprotein | | 分子名称: | Envelope protein E, Human MZ4 Fab heavy chain, Human MZ4 Fab light chain | | 著者 | Sankhala, R.S, Dussupt, V, Donofrio, G, Choe, M, Modjarrad, K, Michael, N.L, Krebs, S.J, Joyce, M.G. | | 登録日 | 2018-12-31 | | 公開日 | 2019-12-25 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (4.303 Å) | | 主引用文献 | Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.
Nat. Med., 26, 2020
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6K7N
 | | Cryo-EM structure of the human P4-type flippase ATP8A1-CDC50 (E1P state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Cell cycle control protein 50A, ... | | 著者 | Hiraizumi, M, Yamashita, K, Nishizawa, T, Nureki, O. | | 登録日 | 2019-06-07 | | 公開日 | 2019-08-28 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | | 主引用文献 | Cryo-EM structures capture the transport cycle of the P4-ATPase flippase.
Science, 365, 2019
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6K2H
 | | structural characterization of mutated NreA protein in nitrate binding site from staphylococcus aureus. | | 分子名称: | 1,2-ETHANEDIOL, NreA | | 著者 | Sangare, L, Chen, W, Wang, C, Chen, X, Wu, M, Zhang, X, Zang, J. | | 登録日 | 2019-05-14 | | 公開日 | 2020-03-11 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural insights into the conformational change of Staphylococcus aureus NreA at C-terminus.
Biotechnol.Lett., 42, 2020
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3OV3
 | | G211F mutant of curcumin synthase 1 from Curcuma longa | | 分子名称: | Curcumin synthase, MALONATE ION | | 著者 | Katsuyama, Y, Miyazono, K, Tanokura, M, Ohnishi, Y, Horinouchi, S. | | 登録日 | 2010-09-15 | | 公開日 | 2010-12-08 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A hydrophobic cavity discovered in a curcumin synthase facilitates utilization of a beta-keto acid as an extender substrate for the atypical type III polyleteide synthase
To be Published
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6K3I
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