3P8F

Crystal Structure of MT-SP1 in complex with SFTI-1

Summary for 3P8F

• Entry DOI: 10.2210/pdb3p8f/pdb
• Related: 3P8G
• Related PRD ID: PRD_001097
• Descriptor: ST14 protein, Trypsin inhibitor 1, GLUTATHIONE, ... (4 entities in total)
• Functional Keywords: protein-inhibitor complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28320.94

Authors

Yuan, C.,Huang, M.,Chen, L. (deposition date: 2010-10-13, release date: 2011-08-10, Last modification date: 2025-03-26)

Primary citation

Yuan, C.,Chen, L.,Meehan, E.J.,Daly, N.,Craik, D.J.,Huang, M.,Ngo, J.C.
Structure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1.
Bmc Struct.Biol., 11:30-30, 2011

PubMed Abstract: Matriptase is a type II transmembrane serine protease that is found on the surfaces of epithelial cells and certain cancer cells. Matriptase has been implicated in the degradation of certain extracellular matrix components as well as the activation of various cellular proteins and proteases, including hepatocyte growth factor and urokinase. Sunflower trypsin inhibitor-1 (SFTI-1), a cyclic peptide inhibitor originally isolated from sunflower seeds, exhibits potent inhibitory activity toward matriptase.

PubMed: 21693064
DOI: 10.1186/1472-6807-11-30

Experimental method

X-RAY DIFFRACTION (2 Å)