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PDB: 152 件
7U6M
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Albumin binding domain fused to a mutant of the Erwinia asparaginase
分子名称: ASPARTIC ACID, L-asparaginase
著者Lavie, A, Nguyen, H.A.
登録日2022-03-04
公開日2022-08-31
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献In vivo stabilization of a less toxic asparaginase variant leads to a durable antitumor response in acute leukemia.
Haematologica, 108, 2023
4TMK
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COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR TP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, PROTEIN (THYMIDYLATE KINASE)
著者Lavie, A, Ostermann, N, Schlichting, I.
登録日1998-08-31
公開日1998-11-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
5TMP
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COMPLEX OF E. COLI THYMIDYLATE KINASE WITH THE BISUBSTRATE INHIBITOR AZTP5A
分子名称: P1-(5'-ADENOSYL)P5-(5'-(3'AZIDO-3'-DEOXYTHYMIDYL))PENTAPHOSPHATE, PROTEIN (THYMIDYLATE KINASE)
著者Lavie, A, Ostermann, N, Schlichting, I.
登録日1998-09-01
公開日1998-11-25
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Structural basis for efficient phosphorylation of 3'-azidothymidine monophosphate by Escherichia coli thymidylate kinase.
Proc.Natl.Acad.Sci.USA, 95, 1998
1TMK
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YEAST THYMIDYLATE KINASE COMPLEXED WITH THYMIDINE MONOPHOSPHATE (DTMP)
分子名称: SULFATE ION, THYMIDINE-5'-PHOSPHATE, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I.
登録日1997-06-12
公開日1998-06-17
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
1XYA
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X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
分子名称: HYDROXIDE ION, MAGNESIUM ION, XYLOSE ISOMERASE
著者Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D.
登録日1994-01-03
公開日1994-05-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYC
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X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
分子名称: 3-O-METHYLFRUCTOSE IN LINEAR FORM, MAGNESIUM ION, XYLOSE ISOMERASE
著者Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D.
登録日1994-01-03
公開日1994-05-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
1XYB
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X-RAY CRYSTALLOGRAPHIC STRUCTURES OF D-XYLOSE ISOMERASE-SUBSTRATE COMPLEXES POSITION THE SUBSTRATE AND PROVIDE EVIDENCE FOR METAL MOVEMENT DURING CATALYSIS
分子名称: D-glucose, MAGNESIUM ION, XYLOSE ISOMERASE
著者Lavie, A, Allen, K.N, Petsko, G.A, Ringe, D.
登録日1994-01-03
公開日1994-05-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis.
Biochemistry, 33, 1994
3QEN
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S74E dCK in complex with 5-bromodeoxycytidine and UDP
分子名称: 5-bromo-2'-deoxycytidine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE
著者Lavie, A, Hazra, S.
登録日2011-01-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.997 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
3QEO
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S74E-R104M-D133A dCK variant in complex with L-deoxythymidine and UDP
分子名称: Deoxycytidine kinase, L-deoxythymidine, URIDINE-5'-DIPHOSPHATE
著者Lavie, A, Hazra, S.
登録日2011-01-20
公開日2011-03-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.897 Å)
主引用文献Post-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and release.
Biochemistry, 50, 2011
2TMK
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YEAST THYMIDYLATE KINASE COMPLEXED WITH 3'-AZIDO-3'-DEOXYTHYMIDINE MONOPHOSPHATE (AZT-MP)
分子名称: 3'-AZIDO-3'-DEOXYTHYMIDINE-5'-MONOPHOSPHATE, SULFATE ION, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I.
登録日1997-06-12
公開日1998-06-17
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of thymidylate kinase reveals the cause behind the limiting step in AZT activation.
Nat.Struct.Biol., 4, 1997
3TMK
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CRYSTAL STRUCTURE OF YEAST THYMIDYLATE KINASE COMPLEXED WITH THE BISUBSTRATE INHIBITOR TP5A AT 2.0 A RESOLUTION: IMPLICATIONS FOR CATALYSIS AND AZT ACTIVATION
分子名称: P1-(5'-ADENOSYL)P5-(5'-THYMIDYL)PENTAPHOSPHATE, THYMIDYLATE KINASE
著者Lavie, A, Schlichting, I, Konrad, M, Goody, R.S, Brundiers, R, Reinstein, J.
登録日1998-01-26
公開日1999-02-16
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of yeast thymidylate kinase complexed with the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-thymidyl) pentaphosphate (TP5A) at 2.0 A resolution: implications for catalysis and AZT activation.
Biochemistry, 37, 1998
2RCZ
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Structure of the second PDZ domain of ZO-1
分子名称: Tight junction protein ZO-1
著者Lavie, A, Lye, M.F.
登録日2007-09-20
公開日2007-10-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Domain swapping within PDZ2 is responsible for dimerization of ZO proteins.
J.Biol.Chem., 282, 2007
3MTR
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Crystal structure of the Ig5-FN1 tandem of human NCAM
分子名称: Neural cell adhesion molecule 1, SULFATE ION
著者Lavie, A, Foley, D.A.
登録日2010-04-30
公開日2010-06-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites
J.Biol.Chem., 285, 2010
1VF6
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2.1 Angstrom crystal structure of the PALS-1-L27N and PATJ L27 heterodimer complex
分子名称: MAGUK p55 subfamily member 5, PALS1-associated tight junction protein
著者Li, Y, Lavie, A, Margolis, B, Karnak, D.
登録日2004-04-09
公開日2004-04-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for L27 domain-mediated assembly of signaling and cell polarity complexes.
Embo J., 23, 2004
4R8L
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BU of 4r8l by Molmil
Crystal structure of the Asp-bound guinea pig L-asparaginase 1 catalytic domain
分子名称: ASPARTIC ACID, Uncharacterized protein
著者Schalk, A.M, Lavie, A.
登録日2014-09-02
公開日2014-10-22
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing Properties.
J.Biol.Chem., 289, 2014
4R8K
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Crystal structure of the guinea pig L-asparaginase 1 catalytic domain
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Uncharacterized protein
著者Schalk, A.M, Lavie, A.
登録日2014-09-02
公開日2014-10-22
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Identification and Structural Analysis of an l-Asparaginase Enzyme from Guinea Pig with Putative Tumor Cell Killing Properties.
J.Biol.Chem., 289, 2014
2GYI
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BU of 2gyi by Molmil
DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A POTENT XYLOSE ISOMERASE INHIBITOR, D-THREONOHYDROXAMIC ACID, AND HIGH-RESOLUTION X-RAY CRYSTALLOGRAPHIC STRUCTURE OF THE ENZYME-INHIBITOR COMPLEX
分子名称: 2,3,4,N-TETRAHYDROXY-BUTYRIMIDIC ACID, MAGNESIUM ION, XYLOSE ISOMERASE
著者Allen, K.N, Lavie, A, Petsko, G.A, Ringe, D.
登録日1994-09-01
公開日1995-07-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Design, Synthesis, and Characterization of a Potent Xylose Isomerase Inhibitor, D-Threonohydroxamic Acid, and High-Resolution X-Ray Crystallographic Structure of the Enzyme-Inhibitor Complex
Biochemistry, 34, 1995
5W6O
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Choline Kinase Alpha in Complex with TCD-717
分子名称: 1,1'-[[1,1'-biphenyl]-4,4'-diylbis(methylene)]bis{4-[(4-chlorophenyl)(methyl)amino]quinolin-1-ium}, 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ...
著者Kall, S.K, Lavie, A.
登録日2017-06-16
公開日2018-02-14
最終更新日2019-12-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Identification of a Unique Inhibitor-Binding Site on Choline Kinase alpha.
Biochemistry, 57, 2018
4YYX
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Crystal structure of the ZO-1 PDZ1 domain in complex with the 7-mer Claudin2 C-terminal tail
分子名称: FORMIC ACID, Tight junction protein ZO-1 fused with Claudin-2 C-terminal
著者Nomme, J, Lavie, A.
登録日2015-03-24
公開日2015-04-01
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Structural Basis of a Key Factor Regulating the Affinity between the Zonula Occludens First PDZ Domain and Claudins.
J.Biol.Chem., 290, 2015
6VMZ
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Crystal Structure of a H5N1 influenza virus hemagglutinin with CBS1117
分子名称: 2,6-dichloro-N-[1-(propan-2-yl)piperidin-4-yl]benzamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin
著者Antanasijevic, A, Durst, M.A, Lavie, A, Caffrey, M.
登録日2020-01-28
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor.
Life Sci Alliance, 3, 2020
1KGD
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Crystal Structure of the Guanylate Kinase-like Domain of Human CASK
分子名称: FORMIC ACID, PERIPHERAL PLASMA MEMBRANE CASK
著者Li, Y, Spangenberg, O, Paarmann, I, Konrad, M, Lavie, A.
登録日2001-11-26
公開日2001-12-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.314 Å)
主引用文献Structural basis for nucleotide-dependent regulation of membrane-associated guanylate kinase-like domains.
J.Biol.Chem., 277, 2002
4ECD
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2.5 Angstrom Resolution Crystal Structure of Bifidobacterium longum Chorismate Synthase
分子名称: CHLORIDE ION, Chorismate synthase
著者Light, S.H, Minasov, G, Krishna, S.N, Shuvalova, L, Kwon, K, Lavie, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日2012-03-26
公開日2012-04-04
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献2.5 Angstrom Resolution Crystal Structure of Bifidobacterium longum Chorismate Synthase
TO BE PUBLISHED
3HP1
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Crystal structure of human dCK R104M/D133A in complex with L-dT and ADP
分子名称: ADENOSINE-5'-DIPHOSPHATE, Deoxycytidine kinase, L-deoxythymidine
著者Hazra, S, Lavie, A.
登録日2009-06-03
公開日2009-06-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Extending Thymidine Kinase Activity to the Catalytic Repertoire of Human Deoxycytidine Kinase.
Biochemistry, 48, 2009
2HAZ
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Crystal structure of the first fibronectin domain of human NCAM1
分子名称: Neural cell adhesion molecule 1, SODIUM ION
著者Sekulic, N, Lavie, A.
登録日2006-06-13
公開日2006-10-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A novel alpha-helix in the first fibronectin type III repeat of the neural cell adhesion molecule is critical for N-glycan polysialylation.
J.Biol.Chem., 281, 2006
5K28
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Structure of the unbound SH3 domain of MLK3
分子名称: Mitogen-activated protein kinase kinase kinase 11
著者Kall, S.K, Lavie, A.
登録日2016-05-18
公開日2017-12-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Identification of two distinct peptide-binding pockets in the SH3 domain of human mixed-lineage kinase 3.
J. Biol. Chem., 293, 2018

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