6NYY
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![BU of 6nyy by Molmil](/molmil-images/mine/6nyy) | human m-AAA protease AFG3L2, substrate-bound | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, AFG3-like protein 2, MAGNESIUM ION, ... | Authors: | Lander, G.C, Puchades, C. | Deposit date: | 2019-02-12 | Release date: | 2019-05-22 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Unique Structural Features of the Mitochondrial AAA+ Protease AFG3L2 Reveal the Molecular Basis for Activity in Health and Disease. Mol.Cell, 75, 2019
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6W1X
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![BU of 6w1x by Molmil](/molmil-images/mine/6w1x) | Cryo-EM structure of anti-CRISPR AcrIF9, bound to the type I-F crRNA-guided CRISPR surveillance complex | Descriptor: | CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy3, ... | Authors: | Hirschi, M, Santiago-Frangos, A, Wilkinson, R, Golden, S.M, Wiedenheft, B, Lander, G. | Deposit date: | 2020-03-04 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex. Nat Commun, 11, 2020
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5UZ9
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![BU of 5uz9 by Molmil](/molmil-images/mine/5uz9) | Cryo EM structure of anti-CRISPRs, AcrF1 and AcrF2, bound to type I-F crRNA-guided CRISPR surveillance complex | Descriptor: | Anti-CRISPR protein 30, Anti-CRISPR protein Acr30-35, CRISPR RNA (60-MER), ... | Authors: | Chowdhury, S, Carter, J, Rollins, M.F, Jackson, R.N, Hoffmann, C, Nosaka, L, Bondy-Denomy, J, Maxwell, K.L, Davidson, A.R, Fischer, E.R, Lander, G.C, Wiedenheft, B. | Deposit date: | 2017-02-25 | Release date: | 2017-04-26 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure Reveals Mechanisms of Viral Suppressors that Intercept a CRISPR RNA-Guided Surveillance Complex. Cell, 169, 2017
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7SXO
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![BU of 7sxo by Molmil](/molmil-images/mine/7sxo) | Yeast Lon (PIM1) with endogenous substrate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | Authors: | Yang, J, Song, A.S, Wiseman, R.L, Lander, G.C. | Deposit date: | 2021-11-24 | Release date: | 2022-01-12 | Last modified: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of hexameric yeast Lon protease (PIM1) highlights the importance of conserved structural elements. J.Biol.Chem., 298, 2022
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6PKX
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![BU of 6pkx by Molmil](/molmil-images/mine/6pkx) | Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+ | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 2, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE | Authors: | Yin, Y, Wu, M, Hsu, A.L, Borschel, W.F, Borgnia, M.J, Lander, G.C, Lee, S.-Y. | Deposit date: | 2019-06-30 | Release date: | 2019-08-28 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Nat Commun, 10, 2019
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8FLJ
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![BU of 8flj by Molmil](/molmil-images/mine/8flj) | Cas1-Cas2/3 integrase and IHF bound to CRISPR leader, repeat and foreign DNA | Descriptor: | CRISPR leader and repeat, anti-sense strand of DNA, CRISPR leader, ... | Authors: | Santiago-Frangos, A, Henriques, W.S, Wiegand, T, Gauvin, C, Buyukyoruk, M, Neselu, K, Eng, E.T, Lander, G.C, Wiedenheft, B. | Deposit date: | 2022-12-21 | Release date: | 2023-09-06 | Last modified: | 2023-11-22 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | Structure reveals why genome folding is necessary for site-specific integration of foreign DNA into CRISPR arrays. Nat.Struct.Mol.Biol., 30, 2023
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6WHI
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![BU of 6whi by Molmil](/molmil-images/mine/6whi) | Cryo-electron microscopy structure of the type I-F CRISPR RNA-guided surveillance complex bound to the anti-CRISPR AcrIF9 | Descriptor: | CRISPR-associated endonuclease Cas6/Csy4, CRISPR-associated protein Csy1, CRISPR-associated protein Csy3, ... | Authors: | Hirschi, M, Santiago-Frangos, A, Wilkinson, R, Golden, S.M, Wiedenheft, B, Lander, G. | Deposit date: | 2020-04-08 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex. Nat Commun, 11, 2020
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6XMJ
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![BU of 6xmj by Molmil](/molmil-images/mine/6xmj) | Human 20S proteasome bound to an engineered 11S (PA26) activator | Descriptor: | Proteasome activator protein PA26, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | Authors: | de la Pena, A.H, Opoku-Nsiah, K.A, Williams, S.K, Chopra, N, Sali, A, Gestwicki, J.E, Lander, G.C. | Deposit date: | 2020-06-30 | Release date: | 2020-07-22 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The Y Phi motif defines the structure-activity relationships of human 20S proteasome activators. Nat Commun, 13, 2022
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7U2B
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![BU of 7u2b by Molmil](/molmil-images/mine/7u2b) | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA(GCU-TL) | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (53-MER), Serine--tRNA ligase, ... | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | Deposit date: | 2022-02-23 | Release date: | 2022-09-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
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3J6E
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![BU of 3j6e by Molmil](/molmil-images/mine/3j6e) | Energy minimized average structure of Microtubules stabilized by GmpCpp | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | Authors: | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | Deposit date: | 2014-02-18 | Release date: | 2014-06-04 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis. Cell(Cambridge,Mass.), 157, 2014
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3J6F
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![BU of 3j6f by Molmil](/molmil-images/mine/3j6f) | Minimized average structure of GDP-bound dynamic microtubules | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | Deposit date: | 2014-02-19 | Release date: | 2014-06-04 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.9 Å) | Cite: | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis. Cell(Cambridge,Mass.), 157, 2014
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4YLS
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![BU of 4yls by Molmil](/molmil-images/mine/4yls) | Tubulin Glutamylase | Descriptor: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tubulin polyglutamylase TTLL7 | Authors: | Garnham, C.P, Vemu, A, Wilson-Kubalek, E.M, Yu, I, Szyk, A, Lander, G.C, Milligan, R.A, Roll-Mecak, A. | Deposit date: | 2015-03-05 | Release date: | 2015-06-17 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Cell, 161, 2015
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7U2A
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![BU of 7u2a by Molmil](/molmil-images/mine/7u2a) | Cryo-electron microscopy structure of human mt-SerRS in complex with mt-tRNA (GCU) | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, RNA (38-MER), Serine--tRNA ligase, ... | Authors: | Hirschi, M, Kuhle, B, Doerfel, L, Schimmel, P, Lander, G. | Deposit date: | 2022-02-23 | Release date: | 2022-09-14 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
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6AZ0
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![BU of 6az0 by Molmil](/molmil-images/mine/6az0) | Mitochondrial ATPase Protease YME1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Puchades, C, Rampello, A.J, Shin, M, Giuliano, C, Wiseman, R.L, Glynn, S.E, Lander, G.C. | Deposit date: | 2017-09-09 | Release date: | 2017-11-15 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure of the mitochondrial inner membrane AAA+ protease YME1 gives insight into substrate processing. Science, 358, 2017
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3J6G
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![BU of 3j6g by Molmil](/molmil-images/mine/3j6g) | Minimized average structure of microtubules stabilized by taxol | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Alushin, G.M, Lander, G.C, Kellogg, E.H, Zhang, R, Baker, D, Nogales, E. | Deposit date: | 2014-02-19 | Release date: | 2014-06-04 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (5.5 Å) | Cite: | High-Resolution Microtubule Structures Reveal the Structural Transitions in alpha beta-Tubulin upon GTP Hydrolysis. Cell(Cambridge,Mass.), 157, 2014
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6V21
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![BU of 6v21 by Molmil](/molmil-images/mine/6v21) | |
7S65
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![BU of 7s65 by Molmil](/molmil-images/mine/7s65) | Compressed conformation of nighttime state KaiC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ... | Authors: | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | Deposit date: | 2021-09-13 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Coupling of distant ATPase domains in the circadian clock protein KaiC. Nat.Struct.Mol.Biol., 29, 2022
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7S67
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![BU of 7s67 by Molmil](/molmil-images/mine/7s67) | Extended conformation of daytime state KaiC | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ... | Authors: | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | Deposit date: | 2021-09-13 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Coupling of distant ATPase domains in the circadian clock protein KaiC. Nat.Struct.Mol.Biol., 29, 2022
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7S66
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![BU of 7s66 by Molmil](/molmil-images/mine/7s66) | Extended conformation of nighttime state KaiC | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION | Authors: | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | Deposit date: | 2021-09-13 | Release date: | 2021-09-22 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Coupling of distant ATPase domains in the circadian clock protein KaiC. Nat.Struct.Mol.Biol., 29, 2022
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7TZB
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![BU of 7tzb by Molmil](/molmil-images/mine/7tzb) | Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue | Descriptor: | 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE, Serine--tRNA ligase, mitochondrial | Authors: | Kuhle, B, Hirschi, M, Doerfel, L, Lander, G, Schimmel, P. | Deposit date: | 2022-02-15 | Release date: | 2022-09-14 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13, 2022
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6BPQ
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![BU of 6bpq by Molmil](/molmil-images/mine/6bpq) | Structure of the cold- and menthol-sensing ion channel TRPM8 | Descriptor: | Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y. | Deposit date: | 2017-11-25 | Release date: | 2017-12-13 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structure of the cold- and menthol-sensing ion channel TRPM8. Science, 359, 2018
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6V20
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![BU of 6v20 by Molmil](/molmil-images/mine/6v20) | |
6V11
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![BU of 6v11 by Molmil](/molmil-images/mine/6v11) | Lon Protease from Yersinia pestis | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease | Authors: | Shin, M, Puchades, C, Asmita, A, Puri, N, Adjei, E, Wiseman, R.L, Karzai, A.W, Lander, G.C. | Deposit date: | 2019-11-19 | Release date: | 2020-01-22 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis for distinct operational modes and protease activation in AAA+ protease Lon. Sci Adv, 6, 2020
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3KO1
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![BU of 3ko1 by Molmil](/molmil-images/mine/3ko1) | Cystal structure of thermosome from Acidianus tengchongensis strain S5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Chaperonin | Authors: | Huo, Y, Zhang, K, Hu, Z, Wang, L, Zhai, Y, Zhou, Q, Lander, G, He, Y, Zhu, J, Xu, W, Dong, Z, Sun, F. | Deposit date: | 2009-11-12 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Crystal structure of group II chaperonin in the open state. Structure, 18, 2010
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3JCK
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![BU of 3jck by Molmil](/molmil-images/mine/3jck) | Structure of the yeast 26S proteasome lid sub-complex | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome regulatory subunit RPN12, 26S proteasome regulatory subunit RPN3, ... | Authors: | Herzik Jr, M.A, Dambacher, C.M, Worden, E.J, Martin, A, Lander, G.C. | Deposit date: | 2015-12-20 | Release date: | 2016-01-20 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Atomic structure of the 26S proteasome lid reveals the mechanism of deubiquitinase inhibition. Elife, 5, 2016
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