7TZB

Crystal structure of the human mitochondrial seryl-tRNA synthetase (mt SerRS) bound with a seryl-adenylate analogue

Summary for 7TZB

Entry DOI	10.2210/pdb7tzb/pdb
Descriptor	Serine--tRNA ligase, mitochondrial, 5'-O-(N-(L-SERYL)-SULFAMOYL)ADENOSINE (2 entities in total)
Functional Keywords	seryl-trna synthetase, mitochondria, aminoacylation, translation, trna, class ii, alpha-beta domain, ligase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	109762.34
Authors	Kuhle, B.,Hirschi, M.,Doerfel, L.,Lander, G.,Schimmel, P. (deposition date: 2022-02-15, release date: 2022-09-14, Last modification date: 2023-10-18)
Primary citation	Kuhle, B.,Hirschi, M.,Doerfel, L.K.,Lander, G.C.,Schimmel, P. Structural basis for shape-selective recognition and aminoacylation of a D-armless human mitochondrial tRNA. Nat Commun, 13:5100-5100, 2022 Cited by PubMed: 36042193 DOI: 10.1038/s41467-022-32544-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.95 Å)

Structure validation