6PKX
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Summary for 6PKX
Entry DOI | 10.2210/pdb6pkx/pdb |
EMDB information | 20367 20368 20369 |
Descriptor | Transient receptor potential cation channel subfamily M member 2, CALCIUM ION, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE (3 entities in total) |
Functional Keywords | warmth sensor, redox sensor, calcium-permeable ion channel, trp channel, trpm channel, ion channel, adp-ribose, transport protein |
Biological source | Danio rerio (Zebrafish) |
Total number of polymer chains | 4 |
Total formula weight | 671633.29 |
Authors | Yin, Y.,Wu, M.,Hsu, A.L.,Borschel, W.F.,Borgnia, M.J.,Lander, G.C.,Lee, S.-Y. (deposition date: 2019-06-30, release date: 2019-08-28, Last modification date: 2019-12-18) |
Primary citation | Yin, Y.,Wu, M.,Hsu, A.L.,Borschel, W.F.,Borgnia, M.J.,Lander, G.C.,Lee, S.Y. Visualizing structural transitions of ligand-dependent gating of the TRPM2 channel. Nat Commun, 10:3740-3740, 2019 Cited by PubMed: 31431622DOI: 10.1038/s41467-019-11733-5 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4.2 Å) |
Structure validation
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