6PKX
Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0005216 | molecular_function | monoatomic ion channel activity |
A | 0005262 | molecular_function | calcium channel activity |
A | 0005509 | molecular_function | calcium ion binding |
A | 0005886 | cellular_component | plasma membrane |
A | 0006811 | biological_process | monoatomic ion transport |
A | 0016020 | cellular_component | membrane |
A | 0019722 | biological_process | calcium-mediated signaling |
A | 0046872 | molecular_function | metal ion binding |
A | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
A | 0051289 | biological_process | protein homotetramerization |
A | 0055085 | biological_process | transmembrane transport |
A | 0070588 | biological_process | calcium ion transmembrane transport |
A | 0072570 | molecular_function | ADP-D-ribose binding |
A | 0072571 | molecular_function | mono-ADP-D-ribose binding |
A | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
A | 0099604 | molecular_function | ligand-gated calcium channel activity |
B | 0005216 | molecular_function | monoatomic ion channel activity |
B | 0005262 | molecular_function | calcium channel activity |
B | 0005509 | molecular_function | calcium ion binding |
B | 0005886 | cellular_component | plasma membrane |
B | 0006811 | biological_process | monoatomic ion transport |
B | 0016020 | cellular_component | membrane |
B | 0019722 | biological_process | calcium-mediated signaling |
B | 0046872 | molecular_function | metal ion binding |
B | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
B | 0051289 | biological_process | protein homotetramerization |
B | 0055085 | biological_process | transmembrane transport |
B | 0070588 | biological_process | calcium ion transmembrane transport |
B | 0072570 | molecular_function | ADP-D-ribose binding |
B | 0072571 | molecular_function | mono-ADP-D-ribose binding |
B | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
B | 0099604 | molecular_function | ligand-gated calcium channel activity |
C | 0005216 | molecular_function | monoatomic ion channel activity |
C | 0005262 | molecular_function | calcium channel activity |
C | 0005509 | molecular_function | calcium ion binding |
C | 0005886 | cellular_component | plasma membrane |
C | 0006811 | biological_process | monoatomic ion transport |
C | 0016020 | cellular_component | membrane |
C | 0019722 | biological_process | calcium-mediated signaling |
C | 0046872 | molecular_function | metal ion binding |
C | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
C | 0051289 | biological_process | protein homotetramerization |
C | 0055085 | biological_process | transmembrane transport |
C | 0070588 | biological_process | calcium ion transmembrane transport |
C | 0072570 | molecular_function | ADP-D-ribose binding |
C | 0072571 | molecular_function | mono-ADP-D-ribose binding |
C | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
C | 0099604 | molecular_function | ligand-gated calcium channel activity |
D | 0005216 | molecular_function | monoatomic ion channel activity |
D | 0005262 | molecular_function | calcium channel activity |
D | 0005509 | molecular_function | calcium ion binding |
D | 0005886 | cellular_component | plasma membrane |
D | 0006811 | biological_process | monoatomic ion transport |
D | 0016020 | cellular_component | membrane |
D | 0019722 | biological_process | calcium-mediated signaling |
D | 0046872 | molecular_function | metal ion binding |
D | 0047631 | molecular_function | ADP-ribose diphosphatase activity |
D | 0051289 | biological_process | protein homotetramerization |
D | 0055085 | biological_process | transmembrane transport |
D | 0070588 | biological_process | calcium ion transmembrane transport |
D | 0072570 | molecular_function | ADP-D-ribose binding |
D | 0072571 | molecular_function | mono-ADP-D-ribose binding |
D | 0099094 | molecular_function | ligand-gated monoatomic cation channel activity |
D | 0099604 | molecular_function | ligand-gated calcium channel activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 3 |
Details | binding site for residue CA B 1601 |
Chain | Residue |
B | GLN860 |
B | ASN883 |
B | GLU1088 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue AR6 B 1602 |
Chain | Residue |
B | GLY311 |
B | THR312 |
B | LYS154 |
B | THR186 |
B | TYR271 |
B | GLY308 |
B | GLY309 |
B | PRO310 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CA D 1601 |
Chain | Residue |
D | GLN860 |
D | ASN883 |
D | GLU1088 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue AR6 D 1602 |
Chain | Residue |
D | LYS154 |
D | THR186 |
D | TYR271 |
D | GLY308 |
D | GLY309 |
D | PRO310 |
D | GLY311 |
D | THR312 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 116 |
Details | INTRAMEM: INTRAMEM => ECO:0000269|PubMed:30250252 |
Chain | Residue | Details |
A | LYS730-TYR742 | |
A | ARG1092-ILE1109 | |
B | LYS730-TYR742 | |
B | ARG1092-ILE1109 | |
C | LYS730-TYR742 | |
C | ARG1092-ILE1109 | |
D | LYS730-TYR742 | |
D | ARG1092-ILE1109 |
site_id | SWS_FT_FI2 |
Number of Residues | 1968 |
Details | TOPO_DOM: Cytoplasmic => ECO:0000305 |
Chain | Residue | Details |
A | THR743-LYS812 | |
C | THR743-LYS812 | |
C | TYR862-ASP880 | |
C | SER931-ARG945 | |
C | ASN1064-SER1091 | |
D | THR743-LYS812 | |
D | TYR862-ASP880 | |
D | SER931-ARG945 | |
D | ASN1064-SER1091 | |
A | TYR862-ASP880 | |
A | SER931-ARG945 | |
A | ASN1064-SER1091 | |
B | THR743-LYS812 | |
B | TYR862-ASP880 | |
B | SER931-ARG945 | |
B | ASN1064-SER1091 |
site_id | SWS_FT_FI3 |
Number of Residues | 520 |
Details | TRANSMEM: Helical => ECO:0000269|PubMed:30250252 |
Chain | Residue | Details |
A | PHE813-ILE833 | |
B | ILE910-PHE930 | |
B | MET946-LEU972 | |
B | LEU1039-PHE1063 | |
C | PHE813-ILE833 | |
C | TRP841-LEU861 | |
C | LEU881-LEU901 | |
C | ILE910-PHE930 | |
C | MET946-LEU972 | |
C | LEU1039-PHE1063 | |
D | PHE813-ILE833 | |
A | TRP841-LEU861 | |
D | TRP841-LEU861 | |
D | LEU881-LEU901 | |
D | ILE910-PHE930 | |
D | MET946-LEU972 | |
D | LEU1039-PHE1063 | |
A | LEU881-LEU901 | |
A | ILE910-PHE930 | |
A | MET946-LEU972 | |
A | LEU1039-PHE1063 | |
B | PHE813-ILE833 | |
B | TRP841-LEU861 | |
B | LEU881-LEU901 |
site_id | SWS_FT_FI4 |
Number of Residues | 208 |
Details | TOPO_DOM: Extracellular => ECO:0000305 |
Chain | Residue | Details |
A | ASP834-SER840 | |
C | GLN902-TYR909 | |
C | ILE973-TRP981 | |
C | PHE1007-TRP1038 | |
D | ASP834-SER840 | |
D | GLN902-TYR909 | |
D | ILE973-TRP981 | |
D | PHE1007-TRP1038 | |
A | GLN902-TYR909 | |
A | ILE973-TRP981 | |
A | PHE1007-TRP1038 | |
B | ASP834-SER840 | |
B | GLN902-TYR909 | |
B | ILE973-TRP981 | |
B | PHE1007-TRP1038 | |
C | ASP834-SER840 |
site_id | SWS_FT_FI5 |
Number of Residues | 96 |
Details | INTRAMEM: Pore-forming => ECO:0000269|PubMed:30250252 |
Chain | Residue | Details |
A | ILE982-LEU1006 | |
B | ILE982-LEU1006 | |
C | ILE982-LEU1006 | |
D | ILE982-LEU1006 |
site_id | SWS_FT_FI6 |
Number of Residues | 32 |
Details | BINDING: BINDING => ECO:0000305|PubMed:30250252 |
Chain | Residue | Details |
A | TYR271 | |
B | ARG278 | |
B | GLY309 | |
B | ARG334 | |
B | GLU857 | |
B | GLN860 | |
B | ASN883 | |
B | GLU1088 | |
C | TYR271 | |
C | ARG278 | |
C | GLY309 | |
A | ARG278 | |
C | ARG334 | |
C | GLU857 | |
C | GLN860 | |
C | ASN883 | |
C | GLU1088 | |
D | TYR271 | |
D | ARG278 | |
D | GLY309 | |
D | ARG334 | |
D | GLU857 | |
A | GLY309 | |
D | GLN860 | |
D | ASN883 | |
D | GLU1088 | |
A | ARG334 | |
A | GLU857 | |
A | GLN860 | |
A | ASN883 | |
A | GLU1088 | |
B | TYR271 |
site_id | SWS_FT_FI7 |
Number of Residues | 4 |
Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
Chain | Residue | Details |
A | ASN1015 | |
B | ASN1015 | |
C | ASN1015 | |
D | ASN1015 |