6PKX

Cryo-EM structure of the zebrafish TRPM2 channel in the presence of ADPR and Ca2+

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005216	molecular_function	monoatomic ion channel activity
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005886	cellular_component	plasma membrane
A	0006811	biological_process	monoatomic ion transport
A	0006816	biological_process	calcium ion transport
A	0016020	cellular_component	membrane
A	0019722	biological_process	calcium-mediated signaling
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0046872	molecular_function	metal ion binding
A	0047631	molecular_function	ADP-ribose diphosphatase activity
A	0051289	biological_process	protein homotetramerization
A	0055085	biological_process	transmembrane transport
A	0070588	biological_process	calcium ion transmembrane transport
A	0072570	molecular_function	ADP-D-ribose binding
A	0072571	molecular_function	mono-ADP-D-ribose binding
A	0099094	molecular_function	ligand-gated monoatomic cation channel activity
A	0099604	molecular_function	ligand-gated calcium channel activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005262	molecular_function	calcium channel activity
B	0005509	molecular_function	calcium ion binding
B	0005886	cellular_component	plasma membrane
B	0006811	biological_process	monoatomic ion transport
B	0006816	biological_process	calcium ion transport
B	0016020	cellular_component	membrane
B	0019722	biological_process	calcium-mediated signaling
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0046872	molecular_function	metal ion binding
B	0047631	molecular_function	ADP-ribose diphosphatase activity
B	0051289	biological_process	protein homotetramerization
B	0055085	biological_process	transmembrane transport
B	0070588	biological_process	calcium ion transmembrane transport
B	0072570	molecular_function	ADP-D-ribose binding
B	0072571	molecular_function	mono-ADP-D-ribose binding
B	0099094	molecular_function	ligand-gated monoatomic cation channel activity
B	0099604	molecular_function	ligand-gated calcium channel activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005262	molecular_function	calcium channel activity
C	0005509	molecular_function	calcium ion binding
C	0005886	cellular_component	plasma membrane
C	0006811	biological_process	monoatomic ion transport
C	0006816	biological_process	calcium ion transport
C	0016020	cellular_component	membrane
C	0019722	biological_process	calcium-mediated signaling
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0046872	molecular_function	metal ion binding
C	0047631	molecular_function	ADP-ribose diphosphatase activity
C	0051289	biological_process	protein homotetramerization
C	0055085	biological_process	transmembrane transport
C	0070588	biological_process	calcium ion transmembrane transport
C	0072570	molecular_function	ADP-D-ribose binding
C	0072571	molecular_function	mono-ADP-D-ribose binding
C	0099094	molecular_function	ligand-gated monoatomic cation channel activity
C	0099604	molecular_function	ligand-gated calcium channel activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005262	molecular_function	calcium channel activity
D	0005509	molecular_function	calcium ion binding
D	0005886	cellular_component	plasma membrane
D	0006811	biological_process	monoatomic ion transport
D	0006816	biological_process	calcium ion transport
D	0016020	cellular_component	membrane
D	0019722	biological_process	calcium-mediated signaling
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0046872	molecular_function	metal ion binding
D	0047631	molecular_function	ADP-ribose diphosphatase activity
D	0051289	biological_process	protein homotetramerization
D	0055085	biological_process	transmembrane transport
D	0070588	biological_process	calcium ion transmembrane transport
D	0072570	molecular_function	ADP-D-ribose binding
D	0072571	molecular_function	mono-ADP-D-ribose binding
D	0099094	molecular_function	ligand-gated monoatomic cation channel activity
D	0099604	molecular_function	ligand-gated calcium channel activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA B 1601

Chain	Residue
B	GLN860
B	ASN883
B	GLU1088

---

site_id	AC2
Number of Residues	8
Details	binding site for residue AR6 B 1602

Chain	Residue
B	GLY311
B	THR312
B	LYS154
B	THR186
B	TYR271
B	GLY308
B	GLY309
B	PRO310

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CA D 1601

Chain	Residue
D	GLN860
D	ASN883
D	GLU1088

---

site_id	AC4
Number of Residues	8
Details	binding site for residue AR6 D 1602

Chain	Residue
D	LYS154
D	THR186
D	TYR271
D	GLY308
D	GLY309
D	PRO310
D	GLY311
D	THR312

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	116
Details	Intramembrane: {"evidences":[{"source":"PubMed","id":"30250252","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	520
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"30250252","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	208
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	164
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	96
Details	Intramembrane: {"description":"Pore-forming","evidences":[{"source":"PubMed","id":"30250252","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	Motif: {"description":"Selectivity filter","evidences":[{"source":"PubMed","id":"30250252","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	40
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30250252","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---