6XMJ

Human 20S proteasome bound to an engineered 11S (PA26) activator

Summary for 6XMJ

• Entry DOI: 10.2210/pdb6xmj/pdb
• EMDB information: 22259
• Descriptor: Proteasome subunit alpha type-6, Proteasome subunit beta type-3, Proteasome subunit beta type-2, ... (15 entities in total)
• Functional Keywords: 11s-bound, 20s proteasome, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 21
• Total formula weight: 523664.12

Authors

de la Pena, A.H.,Opoku-Nsiah, K.A.,Williams, S.K.,Chopra, N.,Sali, A.,Gestwicki, J.E.,Lander, G.C. (deposition date: 2020-06-30, release date: 2020-07-22, Last modification date: 2024-05-15)

• Primary citation: Opoku-Nsiah, K.A.,de la Pena, A.H.,Williams, S.K.,Chopra, N.,Sali, A.,Lander, G.C.,Gestwicki, J.E.; The Y Phi motif defines the structure-activity relationships of human 20S proteasome activators.; Nat Commun, 13:1226-1226, 2022; PubMed: 35264557; DOI: 10.1038/s41467-022-28864-x

Experimental method

ELECTRON MICROSCOPY (3 Å)