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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6XMJ

Human 20S proteasome bound to an engineered 11S (PA26) activator

Functional Information from GO Data
ChainGOidnamespacecontents
A0000502cellular_componentproteasome complex
A0000932cellular_componentP-body
A0003723molecular_functionRNA binding
A0004175molecular_functionendopeptidase activity
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005814cellular_componentcentriole
A0005829cellular_componentcytosol
A0005839cellular_componentproteasome core complex
A0005840cellular_componentribosome
A0005929cellular_componentcilium
A0006511biological_processubiquitin-dependent protein catabolic process
A0016363cellular_componentnuclear matrix
A0019773cellular_componentproteasome core complex, alpha-subunit complex
A0030016cellular_componentmyofibril
A0030017cellular_componentsarcomere
A0033011cellular_componentperinuclear theca
A0035639molecular_functionpurine ribonucleoside triphosphate binding
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0050727biological_processregulation of inflammatory response
A0051059molecular_functionNF-kappaB binding
A0051603biological_processproteolysis involved in protein catabolic process
A0070062cellular_componentextracellular exosome
A0097225cellular_componentsperm midpiece
A0097228cellular_componentsperm principal piece
A0097229cellular_componentsperm end piece
A0097542cellular_componentciliary tip
A0120212cellular_componentsperm head-tail coupling apparatus
A0120238cellular_componentsperm glycocalyx
B0000502cellular_componentproteasome complex
B0000932cellular_componentP-body
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005839cellular_componentproteasome core complex
B0006511biological_processubiquitin-dependent protein catabolic process
B0009615biological_processresponse to virus
B0019773cellular_componentproteasome core complex, alpha-subunit complex
B0034774cellular_componentsecretory granule lumen
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0051603biological_processproteolysis involved in protein catabolic process
B0070062cellular_componentextracellular exosome
B1904813cellular_componentficolin-1-rich granule lumen
C0000502cellular_componentproteasome complex
C0000932cellular_componentP-body
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005814cellular_componentcentriole
C0005829cellular_componentcytosol
C0005839cellular_componentproteasome core complex
C0006511biological_processubiquitin-dependent protein catabolic process
C0019773cellular_componentproteasome core complex, alpha-subunit complex
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0051603biological_processproteolysis involved in protein catabolic process
C0070062cellular_componentextracellular exosome
C0097225cellular_componentsperm midpiece
C0120212cellular_componentsperm head-tail coupling apparatus
D0000502cellular_componentproteasome complex
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005839cellular_componentproteasome core complex
D0006511biological_processubiquitin-dependent protein catabolic process
D0019773cellular_componentproteasome core complex, alpha-subunit complex
D0042802molecular_functionidentical protein binding
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0051603biological_processproteolysis involved in protein catabolic process
D0070062cellular_componentextracellular exosome
E0000502cellular_componentproteasome complex
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005839cellular_componentproteasome core complex
E0006511biological_processubiquitin-dependent protein catabolic process
E0019773cellular_componentproteasome core complex, alpha-subunit complex
E0034774cellular_componentsecretory granule lumen
E0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
E0051603biological_processproteolysis involved in protein catabolic process
E0070062cellular_componentextracellular exosome
E1904813cellular_componentficolin-1-rich granule lumen
F0000502cellular_componentproteasome complex
F0001530molecular_functionlipopolysaccharide binding
F0002376biological_processimmune system process
F0002862biological_processnegative regulation of inflammatory response to antigenic stimulus
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005813cellular_componentcentrosome
F0005829cellular_componentcytosol
F0005839cellular_componentproteasome core complex
F0006511biological_processubiquitin-dependent protein catabolic process
F0019773cellular_componentproteasome core complex, alpha-subunit complex
F0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
F0051603biological_processproteolysis involved in protein catabolic process
F0070062cellular_componentextracellular exosome
G0000502cellular_componentproteasome complex
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005839cellular_componentproteasome core complex
G0006511biological_processubiquitin-dependent protein catabolic process
G0019773cellular_componentproteasome core complex, alpha-subunit complex
G0031625molecular_functionubiquitin protein ligase binding
G0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
G0051603biological_processproteolysis involved in protein catabolic process
G0070062cellular_componentextracellular exosome
H0004298molecular_functionthreonine-type endopeptidase activity
H0005839cellular_componentproteasome core complex
H0051603biological_processproteolysis involved in protein catabolic process
I0004298molecular_functionthreonine-type endopeptidase activity
I0005839cellular_componentproteasome core complex
I0051603biological_processproteolysis involved in protein catabolic process
J0000502cellular_componentproteasome complex
J0005515molecular_functionprotein binding
J0005634cellular_componentnucleus
J0005654cellular_componentnucleoplasm
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0005839cellular_componentproteasome core complex
J0019774cellular_componentproteasome core complex, beta-subunit complex
J0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
J0051603biological_processproteolysis involved in protein catabolic process
J0070062cellular_componentextracellular exosome
K0000502cellular_componentproteasome complex
K0005515molecular_functionprotein binding
K0005634cellular_componentnucleus
K0005654cellular_componentnucleoplasm
K0005737cellular_componentcytoplasm
K0005829cellular_componentcytosol
K0005839cellular_componentproteasome core complex
K0010498biological_processproteasomal protein catabolic process
K0016020cellular_componentmembrane
K0019774cellular_componentproteasome core complex, beta-subunit complex
K0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
K0051603biological_processproteolysis involved in protein catabolic process
K0070062cellular_componentextracellular exosome
L0004298molecular_functionthreonine-type endopeptidase activity
L0005839cellular_componentproteasome core complex
L0051603biological_processproteolysis involved in protein catabolic process
M0005839cellular_componentproteasome core complex
M0051603biological_processproteolysis involved in protein catabolic process
N0005839cellular_componentproteasome core complex
N0051603biological_processproteolysis involved in protein catabolic process
O0000502cellular_componentproteasome complex
O0006508biological_processproteolysis
O0008537cellular_componentproteasome activator complex
O0061136biological_processregulation of proteasomal protein catabolic process
P0000502cellular_componentproteasome complex
P0006508biological_processproteolysis
P0008537cellular_componentproteasome activator complex
P0061136biological_processregulation of proteasomal protein catabolic process
Q0000502cellular_componentproteasome complex
Q0006508biological_processproteolysis
Q0008537cellular_componentproteasome activator complex
Q0061136biological_processregulation of proteasomal protein catabolic process
R0000502cellular_componentproteasome complex
R0006508biological_processproteolysis
R0008537cellular_componentproteasome activator complex
R0061136biological_processregulation of proteasomal protein catabolic process
S0000502cellular_componentproteasome complex
S0006508biological_processproteolysis
S0008537cellular_componentproteasome activator complex
S0061136biological_processregulation of proteasomal protein catabolic process
T0000502cellular_componentproteasome complex
T0006508biological_processproteolysis
T0008537cellular_componentproteasome activator complex
T0061136biological_processregulation of proteasomal protein catabolic process
U0000502cellular_componentproteasome complex
U0006508biological_processproteolysis
U0008537cellular_componentproteasome activator complex
U0061136biological_processregulation of proteasomal protein catabolic process
Functional Information from PROSITE/UniProt
site_idPS00388
Number of Residues23
DetailsPROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdlsaStFSPdGRvfQVEYAmkA
ChainResidueDetails
GTYR7-ALA29
CTYR5-ALA27
ETYR8-ALA30
FTYR6-ALA28
BTYR5-ALA27
DTYR3-ALA25
APHE9-ALA31
site_idPS00854
Number of Residues48
DetailsPROTEASOME_BETA_1 Proteasome beta-type subunits signature. LGIlAndGVLLAAErrnihklldevffse.KiyklnedmacsvaGitSD
ChainResidueDetails
CLEU35-ASP82
KILE5-ASP52
JMET12-ASP59
NLEU12-ASP59
MLEU13-ASP60
LLEU4-ASP51
HMET4-ASP51
IALA4-ASP51
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues12
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q9QUM9","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues2
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P17220","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine; by ABL1 and ABL2","evidences":[{"source":"PubMed","id":"16678104","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues4
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues1
DetailsGlycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues3
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)"}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"17323924","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues3
DetailsActive site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"25599644","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27493187","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsModified residue: {"description":"N-acetylserine","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2008","submissionDatabase":"UniProtKB","authors":["Bienvenut W.V.","von Kriegsheim A.F.","Kolch W."]}},{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22223895","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI22
Number of Residues1
DetailsModified residue: {"description":"N-acetylmethionine","evidences":[{"source":"PubMed","id":"19413330","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"22814378","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI23
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"18502982","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18565852","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19426847","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI24
Number of Residues1
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"O09061","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243531

PDB entries from 2025-10-22

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