1BN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1bn5 by Molmil](/molmil-images/mine/1bn5) | HUMAN METHIONINE AMINOPEPTIDASE 2 | Descriptor: | COBALT (II) ION, METHIONINE AMINOPEPTIDASE, TERTIARY-BUTYL ALCOHOL | Authors: | Liu, S, Widom, J, Kemp, C.W, Crews, C.M, Clardy, J.C. | Deposit date: | 1998-07-31 | Release date: | 1999-07-31 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science, 282, 1998
|
|
1B59
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1b59 by Molmil](/molmil-images/mine/1b59) | COMPLEX OF HUMAN METHIONINE AMINOPEPTIDASE-2 COMPLEXED WITH OVALICIN | Descriptor: | 3,4-DIHYDROXY-2-METHOXY-4-METHYL-3-[2-METHYL-3-(3-METHYL-BUT-2-ENYL) -OXIRANYL]-CYCLOHEXANONE, COBALT (II) ION, PROTEIN (METHIONINE AMINOPEPTIDASE) | Authors: | Liu, S, Clardy, J.C. | Deposit date: | 1999-01-13 | Release date: | 2000-01-14 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science, 282, 1998
|
|
1BOA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1boa by Molmil](/molmil-images/mine/1boa) | HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH ANGIOGENESIS INHIBITOR FUMAGILLIN | Descriptor: | COBALT (II) ION, FUMAGILLIN, METHIONINE AMINOPEPTIDASE | Authors: | Liu, S, Widom, J, Kemp, C.W, Crews, C.M, Clardy, J.C. | Deposit date: | 1998-08-01 | Release date: | 1999-08-01 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science, 282, 1998
|
|
1B6A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1b6a by Molmil](/molmil-images/mine/1b6a) | HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470 | Descriptor: | (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate, COBALT (II) ION, METHIONINE AMINOPEPTIDASE | Authors: | Liu, S, Clardy, J.C. | Deposit date: | 1999-01-13 | Release date: | 2000-01-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of human methionine aminopeptidase-2 complexed with fumagillin. Science, 282, 1998
|
|
3M03
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3m03 by Molmil](/molmil-images/mine/3m03) | Crystal structure of human Orc6 fragment | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Origin recognition complex subunit 6, SULFATE ION | Authors: | Liu, S.X, Wu, L.J, Sun, J, Wang, H.F, Liu, Y.F. | Deposit date: | 2010-03-02 | Release date: | 2011-03-09 | Last modified: | 2014-03-05 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3TB4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3tb4 by Molmil](/molmil-images/mine/3tb4) | Crystal structure of the ISC domain of VibB | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Liu, S, Zhang, C, Niu, B, Li, N, Liu, M, Wei, T, Zhu, D, Xu, S, Gu, L. | Deposit date: | 2011-08-05 | Release date: | 2012-08-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Structural insight into the ISC domain of VibB from Vibrio cholerae at atomic resolution: a snapshot just before the enzymatic reaction Acta Crystallogr.,Sect.D, 68, 2012
|
|
1M1B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1m1b by Molmil](/molmil-images/mine/1m1b) | Crystal Structure of Phosphoenolpyruvate Mutase Complexed with Sulfopyruvate | Descriptor: | MAGNESIUM ION, PHOSPHOENOLPYRUVATE PHOSPHOMUTASE, SULFOPYRUVATE | Authors: | Liu, S, Lu, Z, Jia, Y, Dunaway-Mariano, D, Herzberg, O. | Deposit date: | 2002-06-18 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Dissociative phosphoryl transfer in PEP mutase catalysis: structure of the enzyme/sulfopyruvate complex and kinetic properties of mutants. Biochemistry, 41, 2002
|
|
6M1K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m1k by Molmil](/molmil-images/mine/6m1k) | USP7 in complex with a novel inhibitor | Descriptor: | Ubiquitin carboxyl-terminal hydrolase 7, methyl 4-[[4-[[3-[4-(aminomethyl)phenyl]-2-methyl-7-oxidanylidene-pyrazolo[4,3-d]pyrimidin-6-yl]methyl]-4-oxidanyl-piperidin-1-yl]methyl]-3-chloranyl-benzoate | Authors: | Liu, S.J, Zhou, X.Y, Li, M.L, Sun, H.B, Wen, X.A. | Deposit date: | 2020-02-26 | Release date: | 2021-03-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.255 Å) | Cite: | N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies. Eur.J.Med.Chem., 199, 2020
|
|
8CUH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cuh by Molmil](/molmil-images/mine/8cuh) | Crystal structure of human TEAD2 complexed with its inhibitor TM2. | Descriptor: | 4-[3-(2-cyclohexylethoxy)benzoyl]-N-phenylpiperazine-1-carboxamide, Transcriptional enhancer factor TEF-4 | Authors: | Liu, S, Luo, X. | Deposit date: | 2022-05-17 | Release date: | 2022-11-23 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of a new class of reversible TEA-domain transcription factor inhibitors with a novel binding mode. Elife, 11, 2022
|
|
4ZA1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4za1 by Molmil](/molmil-images/mine/4za1) | Crystal Structure of NosA Involved in Nosiheptide Biosynthesis | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, NosA | Authors: | Liu, S, Guo, H, Zhang, T, Han, L, Yao, P, Zhang, Y, Rong, N, Yu, Y, Lan, W, Wang, C, Ding, J, Wang, R, Liu, W, Cao, C. | Deposit date: | 2015-04-13 | Release date: | 2015-08-19 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-based Mechanistic Insights into Terminal Amide Synthase in Nosiheptide-Represented Thiopeptides Biosynthesis Sci Rep, 5, 2015
|
|
3JSI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3jsi by Molmil](/molmil-images/mine/3jsi) | Human phosphodiesterase 9 in complex with inhibitor | Descriptor: | 6-benzyl-1-cyclopentyl-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Liu, S. | Deposit date: | 2009-09-10 | Release date: | 2009-12-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy. J.Med.Chem., 52, 2009
|
|
4YHV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yhv by Molmil](/molmil-images/mine/4yhv) | Yeast Prp3 C-terminal fragment 325-469 | Descriptor: | ACETIC ACID, U4/U6 small nuclear ribonucleoprotein PRP3 | Authors: | Liu, S, Wahl, M.C. | Deposit date: | 2015-02-27 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. Elife, 4, 2015
|
|
3JSW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3jsw by Molmil](/molmil-images/mine/3jsw) | Human PDE9 in complex with selective inhibitor | Descriptor: | 6-[(3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl]-1-(1-methylethyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | Authors: | Liu, S. | Deposit date: | 2009-09-11 | Release date: | 2009-12-01 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy. J.Med.Chem., 52, 2009
|
|
1D3G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1d3g by Molmil](/molmil-images/mine/1d3g) | HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG | Descriptor: | 2-BIPHENYL-4-YL-6-FLUORO-3-METHYL-QUINOLINE-4-CARBOXYLIC ACID, ACETATE ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | Authors: | Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J. | Deposit date: | 1999-09-29 | Release date: | 2000-09-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure Fold.Des., 8, 2000
|
|
1D3H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1d3h by Molmil](/molmil-images/mine/1d3h) | HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH ANTIPROLIFERATIVE AGENT A771726 | Descriptor: | (2Z)-2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]but-2-enamide, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... | Authors: | Liu, S, Neidhardt, E.A, Grossman, T.H, Ocain, T, Clardy, J. | Deposit date: | 1999-09-29 | Release date: | 2000-08-13 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents. Structure Fold.Des., 8, 2000
|
|
4YHW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yhw by Molmil](/molmil-images/mine/4yhw) | Yeast Prp3 (296-469) in complex with fragment of U4/U6 di-snRNA | Descriptor: | U4 snRNA fragment, U4/U6 small nuclear ribonucleoprotein PRP3, U6 snRNA fragment | Authors: | Liu, S, Wahl, M.C. | Deposit date: | 2015-02-27 | Release date: | 2015-07-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.25 Å) | Cite: | A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing. Elife, 4, 2015
|
|
1KV3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1kv3 by Molmil](/molmil-images/mine/1kv3) | HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Protein-glutamine gamma-glutamyltransferase | Authors: | Liu, S, Cerione, R.A, Clardy, J. | Deposit date: | 2002-01-24 | Release date: | 2002-03-13 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for the guanine nucleotide-binding activity of tissue transglutaminase and its regulation of transamidation activity. Proc.Natl.Acad.Sci.USA, 99, 2002
|
|
1OQF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1oqf by Molmil](/molmil-images/mine/1oqf) | Crystal structure of the 2-methylisocitrate lyase | Descriptor: | 2-methylisocitrate lyase | Authors: | Liu, S, Lu, Z, Dunaway-Mariano, D, Herzberg, O, Structure 2 Function Project (S2F) | Deposit date: | 2003-03-08 | Release date: | 2004-04-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structures of 2-methylisocitrate lyase in complex with product and with isocitrate inhibitor provide insight into lyase substrate specificity, catalysis and evolution. Biochemistry, 44, 2005
|
|
6WVE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6wve by Molmil](/molmil-images/mine/6wve) | Chicken SPCS1 | Descriptor: | Green fluorescent protein,Chicken Signal Peptidase Complex Subunit 1,Green fluorescent protein | Authors: | Liu, S, Li, W. | Deposit date: | 2020-05-05 | Release date: | 2021-01-13 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.429 Å) | Cite: | Termini restraining of small membrane proteins enables structure determination at near-atomic resolution. Sci Adv, 6, 2020
|
|
4WHU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4whu by Molmil](/molmil-images/mine/4whu) | BROMO domain of CREB binding protein | Descriptor: | 2-methoxy-4-{1-[2-(morpholin-4-yl)ethyl]-2-(2-phenylethyl)-1H-benzimidazol-5-yl}cyclohepta-2,4,6-trien-1-one, CREB-binding protein | Authors: | Liu, S. | Deposit date: | 2014-09-23 | Release date: | 2015-10-28 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Direct photocapture of bromodomains using tropolone chemical probes To Be Published
|
|
6A96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6a96 by Molmil](/molmil-images/mine/6a96) | Cryo-EM structure of the human alpha5beta3 GABAA receptor in complex with GABA and Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-5,Gamma-aminobutyric acid receptor subunit alpha-5, ... | Authors: | Liu, S, Xu, L, Guan, F, Liu, Y.T, Cui, Y, Zhang, Q, Bi, G.Q, Zhou, Z.H, Zhang, X, Ye, S. | Deposit date: | 2018-07-11 | Release date: | 2018-10-03 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.51 Å) | Cite: | Cryo-EM structure of the human alpha 5 beta 3 GABAAreceptor. Cell Res., 28, 2018
|
|
8FJP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fjp by Molmil](/molmil-images/mine/8fjp) | Cryo-EM structure of native mosquito salivary gland surface protein 1 (SGS1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, salivary gland surface protein 1 | Authors: | Liu, S, Xia, X, Calvo, E, Zhou, Z.H. | Deposit date: | 2022-12-20 | Release date: | 2023-03-01 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Native structure of mosquito salivary protein uncovers domains relevant to pathogen transmission. Nat Commun, 14, 2023
|
|
1LL1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1ll1 by Molmil](/molmil-images/mine/1ll1) | HYDROXO BRIDGE MET FORM HEMOCYANIN FROM LIMULUS | Descriptor: | CHLORIDE ION, COPPER (II) ION, METCYANIN II | Authors: | Liu, S, Magnus, K. | Deposit date: | 1997-03-17 | Release date: | 1997-08-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Crystallographic Studies of Hydroxo, Nitrosyl, Azido and Fluro met Form Hemocyanin Subunit II from Limulus To be Published
|
|
5HI3
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hi3 by Molmil](/molmil-images/mine/5hi3) | |
8EQB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8eqb by Molmil](/molmil-images/mine/8eqb) | FAM46C/BCCIPalpha/Nanobody complex | Descriptor: | Isoform 2 of BRCA2 and CDKN1A-interacting protein, Synthetic nanobody 1, Terminal nucleotidyltransferase 5C | Authors: | Liu, S, Chen, H, Yin, Y, Bai, X, Zhang, X. | Deposit date: | 2022-10-07 | Release date: | 2023-03-15 | Last modified: | 2023-04-26 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Inhibition of FAM46/TENT5 activity by BCCIP alpha adopting a unique fold. Sci Adv, 9, 2023
|
|