1B6A

HUMAN METHIONINE AMINOPEPTIDASE 2 COMPLEXED WITH TNP-470

Summary for 1B6A

DescriptorMETHIONINE AMINOPEPTIDASE, COBALT (II) ION, (1R,2S,3S,4R)-4-hydroxy-2-methoxy-4-methyl-3-[(2R,3R)-2-methyl-3-(3-methylbut-2-en-1-yl)oxiran-2-yl]cyclohexyl (chloroacetyl)carbamate, ... (4 entities in total)
Functional Keywordsangiogenesis inhibitor, aminopeptidase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total molecular weight53493.29
Authors
Liu, S.,Clardy, J.C. (deposition date: 1999-01-13, release date: 2000-01-13, Last modification date: 2019-11-20)
Primary citation
Liu, S.,Widom, J.,Kemp, C.W.,Crews, C.M.,Clardy, J.
Structure of human methionine aminopeptidase-2 complexed with fumagillin.
Science, 282:1324-1327, 1998
PubMed: 9812898 (PDB entries with the same primary citation)
DOI: 10.1126/science.282.5392.1324
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.6 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21320 1.0% 2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload
171916
PDB entries from 2020-12-02