3JSI

Human phosphodiesterase 9 in complex with inhibitor

Summary for 3JSI

• Entry DOI: 10.2210/pdb3jsi/pdb
• Related: 3DYN
• Descriptor: High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, inhibitor, alternative splicing, cgmp, hydrolase, manganese, metal-binding, phosphoprotein
• Biological source: Homo sapiens (human)
• Cellular location: Isoform PDE9A1: Cell projection, ruffle membrane . Isoform PDE9A2: Cell projection, ruffle membrane . Isoform PDE9A3: Cytoplasm . Isoform PDE9A17: Cytoplasm : O76083
• Total number of polymer chains: 2
• Total formula weight: 78493.98

Authors

Liu, S. (deposition date: 2009-09-10, release date: 2009-12-01, Last modification date: 2023-09-06)

• Primary citation: Verhoest, P.R.,Proulx-Lafrance, C.,Corman, M.,Chenard, L.,Helal, C.J.,Hou, X.,Kleiman, R.,Liu, S.,Marr, E.,Menniti, F.S.,Schmidt, C.J.,Vanase-Frawley, M.,Schmidt, A.W.,Williams, R.D.,Nelson, F.R.,Fonseca, K.R.,Liras, S.; Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy.; J.Med.Chem., 52:7946-7949, 2009; PubMed: 19919087; DOI: 10.1021/jm9015334

Experimental method

X-RAY DIFFRACTION (2.72 Å)