1MBC
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2TPR
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2MA2
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![BU of 2ma2 by Molmil](/molmil-images/mine/2ma2) | Solution structure of RasGRP2 EF hands bound to calcium | Descriptor: | RAS guanyl-releasing protein 2 | Authors: | Kuriyan, J, Iwig, J, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J, Wemmer, D, Roose, J. | Deposit date: | 2013-06-24 | Release date: | 2013-08-21 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife, 2, 2013
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1TRB
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3KK9
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![BU of 3kk9 by Molmil](/molmil-images/mine/3kk9) | CaMKII Substrate Complex B | Descriptor: | Calcium/calmodulin dependent protein kinase II | Authors: | Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H. | Deposit date: | 2009-11-04 | Release date: | 2010-02-09 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (3.206 Å) | Cite: | Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat.Struct.Mol.Biol., 17, 2010
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3KK8
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![BU of 3kk8 by Molmil](/molmil-images/mine/3kk8) | CaMKII Substrate Complex A | Descriptor: | Calcium/calmodulin dependent protein kinase II, MAGNESIUM ION | Authors: | Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H. | Deposit date: | 2009-11-04 | Release date: | 2010-02-09 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat.Struct.Mol.Biol., 17, 2010
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3KL8
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![BU of 3kl8 by Molmil](/molmil-images/mine/3kl8) | CaMKIINtide Inhibitor Complex | Descriptor: | Calcium/calmodulin dependent protein kinase II, Calcium/calmodulin-dependent protein kinase II inhibitor 1 | Authors: | Kuriyan, J, Chao, L.H, Pellicena, P, Deindl, S, Barclay, L.A, Schulman, H. | Deposit date: | 2009-11-06 | Release date: | 2010-02-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.372 Å) | Cite: | Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Nat.Struct.Mol.Biol., 17, 2010
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1A06
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![BU of 1a06 by Molmil](/molmil-images/mine/1a06) | CALMODULIN-DEPENDENT PROTEIN KINASE FROM RAT | Descriptor: | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE | Authors: | Kuriyan, J, Goldberg, J. | Deposit date: | 1997-12-09 | Release date: | 1998-04-08 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the autoinhibition of calcium/calmodulin-dependent protein kinase I. Cell(Cambridge,Mass.), 84, 1996
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1BF5
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![BU of 1bf5 by Molmil](/molmil-images/mine/1bf5) | TYROSINE PHOSPHORYLATED STAT-1/DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*CP*AP*GP*TP*TP*TP*CP*CP*CP*GP*TP*AP*AP*AP*TP*G P*C)-3'), DNA (5'-D(*TP*GP*CP*AP*TP*TP*TP*AP*CP*GP*GP*GP*AP*AP*AP*CP*T P*G)-3'), SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 1-ALPHA/BETA | Authors: | Kuriyan, J, Zhao, Y, Chen, X, Vinkemeier, U, Jeruzalmi, D, Darnell Jr, J.E. | Deposit date: | 1998-05-27 | Release date: | 1998-08-12 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell(Cambridge,Mass.), 93, 1998
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7SA7
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1EQN
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![BU of 1eqn by Molmil](/molmil-images/mine/1eqn) | E.COLI PRIMASE CATALYTIC CORE | Descriptor: | DNA PRIMASE | Authors: | Podobnik, M, McInerney, P, O'Donnell, M, Kuriyan, J. | Deposit date: | 2000-04-05 | Release date: | 2000-06-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases. J.Mol.Biol., 300, 2000
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5IG5
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6UAN
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![BU of 6uan by Molmil](/molmil-images/mine/6uan) | B-Raf:14-3-3 complex | Descriptor: | 14-3-3 zeta, Serine/threonine-protein kinase B-raf | Authors: | Kondo, Y, Ognjenovic, J, Banerjee, S, Karandur, D, Merk, A, Kulhanek, K, Wong, K, Roose, J.P, Subramaniam, S, Kuriyan, J. | Deposit date: | 2019-09-11 | Release date: | 2019-09-25 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Cryo-EM structure of a dimeric B-Raf:14-3-3 complex reveals asymmetry in the active sites of B-Raf kinases. Science, 366, 2019
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2RF9
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![BU of 2rf9 by Molmil](/molmil-images/mine/2rf9) | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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2RFE
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![BU of 2rfe by Molmil](/molmil-images/mine/2rfe) | Crystal structure of the complex between the EGFR kinase domain and a Mig6 peptide | Descriptor: | ERBB receptor feedback inhibitor 1, Epidermal growth factor receptor | Authors: | Zhang, X, Pickin, K.A, Bose, R, Jura, N, Cole, P.A, Kuriyan, J. | Deposit date: | 2007-09-28 | Release date: | 2007-12-04 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Inhibition of the EGF receptor by binding of MIG6 to an activating kinase domain interface. Nature, 450, 2007
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2GS6
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![BU of 2gs6 by Molmil](/molmil-images/mine/2gs6) | Crystal Structure of the active EGFR kinase domain in complex with an ATP analog-peptide conjugate | Descriptor: | CHLORIDE ION, Epidermal growth factor receptor, Peptide, ... | Authors: | Zhang, X, Gureasko, J, Shen, K, Cole, P.A, Kuriyan, J. | Deposit date: | 2006-04-25 | Release date: | 2006-06-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor Cell(Cambridge,Mass.), 125, 2006
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5WDO
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![BU of 5wdo by Molmil](/molmil-images/mine/5wdo) | H-Ras bound to GMP-PNP at 277K | Descriptor: | CALCIUM ION, GTPase HRas, MAGNESIUM ION, ... | Authors: | Cofsky, J.C, Bandaru, P, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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5WDS
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![BU of 5wds by Molmil](/molmil-images/mine/5wds) | Choanoflagellate Salpingoeca rosetta Ras with GDP bound | Descriptor: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Kondo, Y, Gee, C.L, Kuriyan, J. | Deposit date: | 2017-07-05 | Release date: | 2017-07-19 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Deconstruction of the Ras switching cycle through saturation mutagenesis. Elife, 6, 2017
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8E4T
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![BU of 8e4t by Molmil](/molmil-images/mine/8e4t) | Crystal structure of the kinase domain of RTKC8 from the choanoflagellate Monosiga brevicollis | Descriptor: | PHOSPHATE ION, RTKC8 Kinase domain, STAUROSPORINE | Authors: | Bajaj, T, Gee, C.L, Kuriyan, J. | Deposit date: | 2022-08-18 | Release date: | 2023-06-21 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Crystal structure of the kinase domain of a receptor tyrosine kinase from a choanoflagellate, Monosiga brevicollis. Plos One, 18, 2023
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6OF9
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7REC
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![BU of 7rec by Molmil](/molmil-images/mine/7rec) | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC | Descriptor: | 5-hydroxydiclofenac, Calcium/calmodulin-dependent protein kinase type II subunit alpha, SODIUM ION | Authors: | McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. | Deposit date: | 2021-07-12 | Release date: | 2021-07-21 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain. Proc.Natl.Acad.Sci.USA, 118, 2021
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4L9M
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![BU of 4l9m by Molmil](/molmil-images/mine/4l9m) | Autoinhibited state of the Ras-specific exchange factor RasGRP1 | Descriptor: | CITRIC ACID, GLYCEROL, RAS guanyl-releasing protein 1, ... | Authors: | Iwig, J.S, Vercoulen, Y, Das, R, Barros, T, Limnander, A, Che, Y, Pelton, J.G, Wemmer, D.E, Roose, J.P, Kuriyan, J. | Deposit date: | 2013-06-18 | Release date: | 2013-08-21 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural analysis of autoinhibition in the Ras-specific exchange factor RasGRP1. Elife, 2, 2013
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7SZ7
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![BU of 7sz7 by Molmil](/molmil-images/mine/7sz7) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to TGF-alpha. "tips-juxtaposed" conformation | Descriptor: | Epidermal growth factor receptor, Transforming growth factor alpha | Authors: | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | Deposit date: | 2021-11-25 | Release date: | 2021-12-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SZ1
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![BU of 7sz1 by Molmil](/molmil-images/mine/7sz1) | Cryo-EM structure of the extracellular module of the full-length EGFR L834R bound to EGF. "tips-separated" conformation | Descriptor: | Epidermal growth factor, Epidermal growth factor receptor | Authors: | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | Deposit date: | 2021-11-25 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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7SYD
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![BU of 7syd by Molmil](/molmil-images/mine/7syd) | Cryo-EM structure of the extracellular module of the full-length EGFR bound to EGF "tips-juxtaposed" conformation | Descriptor: | Epidermal growth factor, Epidermal growth factor receptor | Authors: | Huang, Y, Ognjenovic, J, Karandur, D, Miller, K, Merk, A, Subramaniam, S, Kuriyan, J. | Deposit date: | 2021-11-24 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A molecular mechanism for the generation of ligand-dependent differential outputs by the epidermal growth factor receptor. Elife, 10, 2021
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