7REC

Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CaMKII alpha hub bound to 5-HDC

Summary for 7REC

• Entry DOI: 10.2210/pdb7rec/pdb
• Descriptor: Calcium/calmodulin-dependent protein kinase type II subunit alpha, 5-hydroxydiclofenac, SODIUM ION, ... (4 entities in total)
• Functional Keywords: camkii hub, oligomer, signaling protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 7
• Total formula weight: 110756.92

Authors

McSpadden, E.D.,Chi, C.C.,Gee, C.L.,Kuriyan, J. (deposition date: 2021-07-12, release date: 2021-07-21, Last modification date: 2023-10-18)

• Primary citation: Leurs, U.,Klein, A.B.,McSpadden, E.D.,Griem-Krey, N.,Solbak, S.M.O.,Houlton, J.,Villumsen, I.S.,Vogensen, S.B.,Hamborg, L.,Gauger, S.J.,Palmelund, L.B.,Larsen, A.S.G.,Shehata, M.A.,Kelstrup, C.D.,Olsen, J.V.,Bach, A.,Burnie, R.O.,Kerr, D.S.,Gowing, E.K.,Teurlings, S.M.W.,Chi, C.C.,Gee, C.L.,Frolund, B.,Kornum, B.R.,van Woerden, G.M.,Clausen, R.P.,Kuriyan, J.,Clarkson, A.N.,Wellendorph, P.; GHB analogs confer neuroprotection through specific interaction with the CaMKII alpha hub domain.; Proc.Natl.Acad.Sci.USA, 118:-, 2021; PubMed: 34330837; DOI: 10.1073/pnas.2108079118

Experimental method

X-RAY DIFFRACTION (2.2 Å)