Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 103 件
4KM5
DownloadVisualize
BU of 4km5 by Molmil
X-ray crystal structure of human cyclic GMP-AMP synthase (cGAS)
分子名称: Cyclic GMP-AMP synthase, ZINC ION
著者Kranzusch, P.J, Lee, A.S.Y, Berger, J.M, Doudna, J.A.
登録日2013-05-08
公開日2013-05-29
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity.
Cell Rep, 3, 2013
4TXY
DownloadVisualize
BU of 4txy by Molmil
Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase, a prokaryotic cGAS homolog
分子名称: Cyclic AMP-GMP synthase, MAGNESIUM ION
著者Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A.
登録日2014-07-07
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3.0001 Å)
主引用文献Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
Cell, 158, 2014
4TY0
DownloadVisualize
BU of 4ty0 by Molmil
Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with linear intermediate 5' pppA(3',5')pG
分子名称: ACETATE ION, Cyclic AMP-GMP synthase, MAGNESIUM ION, ...
著者Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A.
登録日2014-07-07
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
Cell, 158, 2014
4TXZ
DownloadVisualize
BU of 4txz by Molmil
Crystal structure of Vibrio cholerae DncV cyclic AMP-GMP synthase in complex with nonhydrolyzable GTP
分子名称: Cyclic AMP-GMP synthase, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
著者Kranzusch, P.J, Lee, A.S.Y, Wilson, S.C, Solovykh, M.S, Vance, R.E, Berger, J.M, Doudna, J.A.
登録日2014-07-07
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity.
Cell, 158, 2014
5K4C
DownloadVisualize
BU of 5k4c by Molmil
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 2
分子名称: Eukaryotic translation initiation factor 3 subunit D, GLYCEROL
著者Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D.
登録日2016-05-20
公開日2016-07-27
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.698 Å)
主引用文献eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
5K4B
DownloadVisualize
BU of 5k4b by Molmil
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 1
分子名称: CHLORIDE ION, Eukaryotic translation initiation factor 3 subunit D
著者Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D.
登録日2016-05-20
公開日2016-07-27
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.399 Å)
主引用文献eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
5K4D
DownloadVisualize
BU of 5k4d by Molmil
Structure of eukaryotic translation initiation factor 3 subunit D (eIF3d) cap binding domain from Nasonia vitripennis, Crystal form 3
分子名称: Eukaryotic translation initiation factor 3 subunit D
著者Kranzusch, P.J, Lee, A.S.Y, Doudna, J.A, Cate, J.H.D.
登録日2016-05-20
公開日2016-07-27
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献eIF3d is an mRNA cap-binding protein that is required for specialized translation initiation.
Nature, 536, 2016
5CFN
DownloadVisualize
BU of 5cfn by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3',3' c-di-AMP, c[A(3',5')pA(3',5')p]
分子名称: (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, Stimulator of Interferon Genes
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFP
DownloadVisualize
BU of 5cfp by Molmil
Crystal structure of anemone STING (Nematostella vectensis) 'humanized' F276K in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]'
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Stimulator of Interferon Genes
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.066 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFO
DownloadVisualize
BU of 5cfo by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in apo 'rotated' open conformation
分子名称: Stimulator of Interferon Genes
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.102 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFL
DownloadVisualize
BU of 5cfl by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' c-di-GMP, c[G(3', 5')pG(3', 5')p]
分子名称: 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CITRATE ANION, Stimulator of Interferon Genes
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.836 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFR
DownloadVisualize
BU of 5cfr by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in apo 'unrotated' closed conformation
分子名称: CALCIUM ION, Stimulator of Interferon Genes
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFQ
DownloadVisualize
BU of 5cfq by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 2',3' cGAMP, c[G(2',5')pA(3',5')p]
分子名称: SULFATE ION, Stimulator of Interferon Genes, cGAMP
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
5CFM
DownloadVisualize
BU of 5cfm by Molmil
Crystal structure of anemone STING (Nematostella vectensis) in complex with 3', 3' cGAMP, c[G(3', 5')pA(3', 5')p]
分子名称: 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, CITRATE ANION, Stimulator of Interferon Genes
著者Kranzusch, P.J, Wilson, S.C, Lee, A.S.Y, Berger, J.M, Doudna, J.A, Vance, R.E.
登録日2015-07-08
公開日2015-08-26
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Ancient Origin of cGAS-STING Reveals Mechanism of Universal 2',3' cGAMP Signaling.
Mol.Cell, 59, 2015
6M7K
DownloadVisualize
BU of 6m7k by Molmil
Structure of mouse RECON (AKR1C13) in complex with cyclic AMP-AMP-GMP (cAAG)
分子名称: 1,2-ETHANEDIOL, Aldo-keto reductase family 1 member C13, cyclic AMP-AMP-GMP
著者Eaglesham, J.B, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Nieminen, E.A, King, D.S, Lee, A.S.Y, Mekalanos, J.J, Kranzusch, P.J.
登録日2018-08-20
公開日2019-02-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.1 Å)
主引用文献Bacterial cGAS-like enzymes synthesize diverse nucleotide signals.
Nature, 567, 2019
6XB4
DownloadVisualize
BU of 6xb4 by Molmil
Structure of PrGV poxin in post-reactive state with Gp[2'-5']Ap[3']
分子名称: 2',5'-GpAp, Poxin
著者Eaglesham, J.B, McCarty, K.L, Kranzusch, P.J.
登録日2020-06-05
公開日2020-11-25
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict.
Elife, 9, 2020
6XB3
DownloadVisualize
BU of 6xb3 by Molmil
Structure of AcNPV poxin in post-reactive state with Gp[2'-5']Ap[3']
分子名称: 2',5'-GpAp, Poxin
著者Eaglesham, J.B, McCarty, K.L, Kranzusch, P.J.
登録日2020-06-05
公開日2020-11-25
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structures of diverse poxin cGAMP nucleases reveal a widespread role for cGAS-STING evasion in host-pathogen conflict.
Elife, 9, 2020
9ARD
DownloadVisualize
BU of 9ard by Molmil
Structure of Pycsar EcPycC cyclase immunoglobulin-like AGS-C domain
分子名称: Cytidylate cyclase
著者Richmond-Buccola, D, Kranzusch, P.J.
登録日2024-02-23
公開日2024-06-19
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion.
Cell Host Microbe, 2024
5I4A
DownloadVisualize
BU of 5i4a by Molmil
X-ray crystal structure of Marinitoga piezophila Argonaute in complex with 5' OH guide RNA
分子名称: Argonaute protein, RNA (5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*U)-3')
著者Doxzen, K.W, Kaya, E, Knoll, K.R, Wilson, R.C, Strutt, S.C, Kranzusch, P.J, Doudna, J.A.
登録日2016-02-11
公開日2016-03-30
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献A bacterial Argonaute with noncanonical guide RNA specificity.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DS6
DownloadVisualize
BU of 5ds6 by Molmil
Crystal structure the Escherichia coli Cas1-Cas2 complex bound to protospacer DNA with splayed ends
分子名称: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2, DNA (28-MER), ...
著者Nunez, J.K, Harrington, L.B, Kranzusch, P.J, Engelman, A.N, Doudna, J.A.
登録日2015-09-16
公開日2015-10-28
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.352 Å)
主引用文献Foreign DNA capture during CRISPR-Cas adaptive immunity.
Nature, 527, 2015
4P6I
DownloadVisualize
BU of 4p6i by Molmil
Crystal structure of the Cas1-Cas2 complex from Escherichia coli
分子名称: CRISPR-associated endonuclease Cas1, CRISPR-associated endoribonuclease Cas2
著者Nunez, J.K, Kranzusch, P.J, Noeske, J, Doudna, J.A.
登録日2014-03-24
公開日2014-05-07
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Cas1-Cas2 complex formation mediates spacer acquisition during CRISPR-Cas adaptive immunity.
Nat.Struct.Mol.Biol., 21, 2014
7N50
DownloadVisualize
BU of 7n50 by Molmil
Structure of a bacterial gasdermin from Bradyrhizobium tropiciagri
分子名称: Gasdermin
著者Johnson, A.G, Kranzusch, P.J.
登録日2021-06-04
公開日2021-06-23
最終更新日2022-01-26
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Bacterial gasdermins reveal an ancient mechanism of cell death.
Science, 375, 2022
7N52
DownloadVisualize
BU of 7n52 by Molmil
Structure of a bacterial gasdermin from Runella zeae
分子名称: Gasdermin
著者Johnson, A.G, Kranzusch, P.J.
登録日2021-06-04
公開日2021-06-23
最終更新日2022-01-26
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Bacterial gasdermins reveal an ancient mechanism of cell death.
Science, 375, 2022
7N51
DownloadVisualize
BU of 7n51 by Molmil
Structure of a bacterial gasdermin from Vitiosangium sp.
分子名称: Gasdermin
著者Johnson, A.G, Kranzusch, P.J.
登録日2021-06-04
公開日2021-06-16
最終更新日2022-01-26
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Bacterial gasdermins reveal an ancient mechanism of cell death.
Science, 375, 2022
8GJY
DownloadVisualize
BU of 8gjy by Molmil
Structure of a cGAS-like receptor Sp-cGLR1 from S. pistillata
分子名称: cGAS-like receptor 1
著者Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J.
登録日2023-03-16
公開日2023-07-05
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献cGLRs are a diverse family of pattern recognition receptors in innate immunity.
Cell, 186, 2023

222624

件を2024-07-17に公開中

PDB statisticsPDBj update infoContact PDBjnumon