7HVP
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![BU of 7hvp by Molmil](/molmil-images/mine/7hvp) | X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN A SYNTHETIC PROTEASE OF HUMAN IMMUNODEFICIENCY VIRUS 1 AND A SUBSTRATE-BASED HYDROXYETHYLAMINE INHIBITOR | Descriptor: | HIV-1 PROTEASE, INHIBITOR ACE-SER-LEU-ASN-PHE-PSI(CH(OH)-CH2N)-PRO-ILE VME (JG-365) | Authors: | Swain, A.L, Miller, M.M, Green, J, Rich, D.H, Schneider, J, Kent, S.B.H, Wlodawer, A. | Deposit date: | 1990-09-13 | Release date: | 1993-07-15 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | X-ray crystallographic structure of a complex between a synthetic protease of human immunodeficiency virus 1 and a substrate-based hydroxyethylamine inhibitor. Proc.Natl.Acad.Sci.USA, 87, 1990
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5HHD
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![BU of 5hhd by Molmil](/molmil-images/mine/5hhd) | Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21 | Descriptor: | D-Peptide RFX037.D, D-Vascular endothelial growth factor, DI(HYDROXYETHYL)ETHER, ... | Authors: | Uppalapati, M, LEE, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. | Deposit date: | 2016-01-10 | Release date: | 2016-03-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
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4GLU
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![BU of 4glu by Molmil](/molmil-images/mine/4glu) | Crystal structure of the mirror image form of VEGF-A | Descriptor: | ACETATE ION, D- Vascular endothelial growth factor-A, GLYCEROL, ... | Authors: | Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H. | Deposit date: | 2012-08-14 | Release date: | 2012-09-05 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GLN
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![BU of 4gln by Molmil](/molmil-images/mine/4gln) | Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21/n | Descriptor: | D-RFX001, Vascular endothelial growth factor A | Authors: | Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H. | Deposit date: | 2012-08-14 | Release date: | 2012-09-05 | Last modified: | 2019-04-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109, 2012
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4GLS
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![BU of 4gls by Molmil](/molmil-images/mine/4gls) | Crystal Structure of Chemically Synthesized Heterochiral {D-Protein Antagonist plus VEGF-A} Protein Complex in space group P21 | Descriptor: | D- RFX001, D- Vascular endothelial growth factor-A, DI(HYDROXYETHYL)ETHER, ... | Authors: | Mandal, K, Uppalapati, M, Ault-Riche, D, Kenney, J, Lowitz, J, Sidhu, S, Kent, S.B.H. | Deposit date: | 2012-08-14 | Release date: | 2012-09-05 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography. Proc.Natl.Acad.Sci.USA, 109, 2012
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8HVP
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![BU of 8hvp by Molmil](/molmil-images/mine/8hvp) | STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR | Descriptor: | HIV-1 PROTEASE, INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL (U-85548E) | Authors: | Jaskolski, M, Miller, M, Tomasselli, A.G, Sawyer, T.K, Staples, D.G, Heinrikson, R.L, Schneider, J, Kent, S.B.H, Wlodawer, A. | Deposit date: | 1990-10-26 | Release date: | 1993-10-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor. Biochemistry, 30, 1991
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5I5C
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![BU of 5i5c by Molmil](/molmil-images/mine/5i5c) | X-ray crystal structure of allo-Thr31-ShK | Descriptor: | GLYCEROL, Kappa-stichotoxin-She3a, LITHIUM ION, ... | Authors: | Dang, B, Kubota, T, Manda, K.l, Shen, R, Bezanilla, F, Roux, B, Kent, S.B.H. | Deposit date: | 2016-02-15 | Release date: | 2017-01-25 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angew. Chem. Int. Ed. Engl., 56, 2017
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5I5B
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![BU of 5i5b by Molmil](/molmil-images/mine/5i5b) | quasi racemic structure of allo-Thr13-ShK and D-ShK | Descriptor: | D-ShK, GLYCEROL, Kappa-stichotoxin-She3a, ... | Authors: | Dang, B, Kubota, T, Mandal, K, Shen, R, Bezanilla, F, Roux, B, Kent, S.B.H. | Deposit date: | 2016-02-15 | Release date: | 2017-01-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angew. Chem. Int. Ed. Engl., 56, 2017
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5I5A
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![BU of 5i5a by Molmil](/molmil-images/mine/5i5a) | quasi racemic structure of allo-Ile7-ShK and D-ShK | Descriptor: | D-MALATE, D-ShK, GLYCEROL, ... | Authors: | Dang, B, Kubota, T, Mandal, K, Shen, R, Bezanilla, F, Roux, B, Kent, S.B.H. | Deposit date: | 2016-02-14 | Release date: | 2017-01-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Inversion of the Side-Chain Stereochemistry of Indvidual Thr or Ile Residues in a Protein Molecule: Impact on the Folding, Stability, and Structure of the ShK Toxin. Angew. Chem. Int. Ed. Engl., 56, 2017
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1LPV
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![BU of 1lpv by Molmil](/molmil-images/mine/1lpv) | DROSOPHILA MELANOGASTER DOUBLESEX (DSX), NMR, 18 STRUCTURES | Descriptor: | Doublesex protein, ZINC ION | Authors: | Zhu, L, Wilken, J, Phillips, N, Narendra, U, Chan, G, Stratton, S, Kent, S, Weiss, M.A. | Deposit date: | 2002-05-08 | Release date: | 2002-10-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Sexual dimorphism in diverse metazoans is regulated by a novel class of intertwined zinc fingers. Genes Dev., 14, 2000
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4HVP
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![BU of 4hvp by Molmil](/molmil-images/mine/4hvp) | Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 Angstroms resolution | Descriptor: | HIV-1 PROTEASE, N-{(2S)-2-[(N-acetyl-L-threonyl-L-isoleucyl)amino]hexyl}-L-norleucyl-L-glutaminyl-N~5~-[amino(iminio)methyl]-L-ornithinamide | Authors: | Miller, M, Schneider, J, Sathyanarayana, B.K, Toth, M.V, Marshall, G.R, Clawson, L, Selk, L, Kent, S.B.H, Wlodawer, A. | Deposit date: | 1989-08-08 | Release date: | 1990-04-15 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution. Science, 246, 1989
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5HHC
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![BU of 5hhc by Molmil](/molmil-images/mine/5hhc) | Crystal Structure of Chemically Synthesized Heterochiral {RFX037 plus VEGF-A} Protein Complex in space group P21/n | Descriptor: | D- Vascular endothelial growth factor-A, GLYCEROL, Vascular endothelial growth factor A | Authors: | Uppalapati, M, Lee, D.J, Mandal, K, Kent, S.B.H, Sidhu, S. | Deposit date: | 2016-01-10 | Release date: | 2016-03-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A Potent d-Protein Antagonist of VEGF-A is Nonimmunogenic, Metabolically Stable, and Longer-Circulating in Vivo. Acs Chem.Biol., 11, 2016
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4WSP
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![BU of 4wsp by Molmil](/molmil-images/mine/4wsp) | Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-I) | Descriptor: | CHLORIDE ION, protein DL-Rv1738 | Authors: | Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N. | Deposit date: | 2014-10-28 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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4WPY
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![BU of 4wpy by Molmil](/molmil-images/mine/4wpy) | Racemic crystal structure of Rv1738 from Mycobacterium tuberculosis (Form-II) | Descriptor: | GLYCEROL, protein DL-Rv1738, trifluoroacetic acid | Authors: | Bunker, R.D, Mandal, K, Kent, S.B.H, Baker, E.N. | Deposit date: | 2014-10-21 | Release date: | 2015-03-18 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography. Proc.Natl.Acad.Sci.USA, 112, 2015
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1HYK
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![BU of 1hyk by Molmil](/molmil-images/mine/1hyk) | AGOUTI-RELATED PROTEIN (87-132) (AC-AGRP(87-132)) | Descriptor: | AGOUTI RELATED PROTEIN | Authors: | Bolin, K.A, Anderson, D.J, Trulson, J.A, Thompson, D.A, Wilken, J, Kent, S.B.H, Millhauser, G.L. | Deposit date: | 2001-01-19 | Release date: | 2001-02-07 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | NMR structure of a minimized human agouti related protein prepared by total chemical synthesis. FEBS Lett., 451, 1999
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4IUZ
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![BU of 4iuz by Molmil](/molmil-images/mine/4iuz) | High resolution crystal structure of racemic ester insulin | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Insulin A chain, ... | Authors: | Avital-Shmilovici, M, Mandal, K, Gates, Z.P, Phillips, N, Weiss, M.A, Kent, S.B.H. | Deposit date: | 2013-01-22 | Release date: | 2013-02-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography. J.Am.Chem.Soc., 135, 2013
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5EN9
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![BU of 5en9 by Molmil](/molmil-images/mine/5en9) | High resolution x-ray crystal structure of isotope-labeled ester-insulin | Descriptor: | Insulin chain A, Insulin chain B | Authors: | Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H. | Deposit date: | 2015-11-09 | Release date: | 2016-01-13 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin. Chembiochem, 17, 2016
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5ENA
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![BU of 5ena by Molmil](/molmil-images/mine/5ena) | Xray crystal structure of isotope-labeled human insulin | Descriptor: | Insulin chain A, Insulin chain B | Authors: | Mandal, K, Dhayalan, B, Avital-Shmilovici, M, Tokmakoff, A, Kent, S.B.H. | Deposit date: | 2015-11-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin. Chembiochem, 17, 2016
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1B3A
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![BU of 1b3a by Molmil](/molmil-images/mine/1b3a) | TOTAL CHEMICAL SYNTHESIS AND HIGH-RESOLUTION CRYSTAL STRUCTURE OF THE POTENT ANTI-HIV PROTEIN AOP-RANTES | Descriptor: | PENTYLOXYAMINO-ACETALDEHYDE, PROTEIN (RANTES), SULFATE ION | Authors: | Wilken, J, Hoover, D, Thompson, D.A, Barlow, P.N, Mcsparron, H, Picard, L, Wlodawer, A, Lubkowski, J, Kent, S.B.H. | Deposit date: | 1998-12-07 | Release date: | 1999-04-23 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Total chemical synthesis and high-resolution crystal structure of the potent anti-HIV protein AOP-RANTES. Chem.Biol., 6, 1999
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5UDP
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![BU of 5udp by Molmil](/molmil-images/mine/5udp) | High resolution x-ray crystal structure of synthetic insulin lispro | Descriptor: | CHLORIDE ION, Insulin Lispro A chain, Insulin Lispro B chain, ... | Authors: | Mandal, K, Dhayalan, B, Kent, S.B.H. | Deposit date: | 2016-12-28 | Release date: | 2017-01-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.348 Å) | Cite: | Scope and Limitations of Fmoc Chemistry SPPS-Based Approaches to the Total Synthesis of Insulin Lispro via Ester Insulin. Chemistry, 23, 2017
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7LL8
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![BU of 7ll8 by Molmil](/molmil-images/mine/7ll8) | D-Protein RFX-V1 Bound to the VEGFR1 Domain 2 Site on VEGF-A | Descriptor: | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V1 | Authors: | Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. | Deposit date: | 2021-02-03 | Release date: | 2021-02-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chem.Biol., 16, 2021
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7LL9
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![BU of 7ll9 by Molmil](/molmil-images/mine/7ll9) | D-Protein RFX-V2 Bound to the VEGFR1 Domain 3 Site on VEGF-A | Descriptor: | Isoform L-VEGF189 of Vascular endothelial growth factor A, RFX-V2 | Authors: | Marinec, P.S, Landgraf, K.E, Uppalapati, M, Chen, G, Xie, D, Jiang, Q, Zhao, Y, Petriello, A, Deshayes, K, Kent, S.B.H, Ault-Riche, D, Sidhu, S.S. | Deposit date: | 2021-02-03 | Release date: | 2021-03-03 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A Non-immunogenic Bivalent d-Protein Potently Inhibits Retinal Vascularization and Tumor Growth. Acs Chem.Biol., 16, 2021
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2LET
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![BU of 2let by Molmil](/molmil-images/mine/2let) | AN 1H NMR DETERMINATION OF THE THREE DIMENSIONAL STRUCTURES OF MIRROR IMAGE FORMS OF A LEU-5 VARIANT OF THE TRYPSIN INHIBITOR ECBALLIUM ELATERIUM (EETI-II) | Descriptor: | TRYPSIN INHIBITOR II | Authors: | Nielsen, K.J, Alewood, D, Andrews, J, Kent, S.B.H, Craik, D.J. | Deposit date: | 1994-01-04 | Release date: | 1994-05-31 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | An 1H NMR determination of the three-dimensional structures of mirror-image forms of a Leu-5 variant of the trypsin inhibitor from Ecballium elaterium (EETI-II). Protein Sci., 3, 1994
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4OIK
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![BU of 4oik by Molmil](/molmil-images/mine/4oik) | (Quasi-)Racemic X-ray crystal structure of glycosylated chemokine Ser-CCL1. | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1, CITRIC ACID, ... | Authors: | Okamoto, R, Mandal, K, Sawaya, M.R, Kajihara, Y, Yeates, T.O, Kent, S.B.H. | Deposit date: | 2014-01-19 | Release date: | 2014-05-07 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | (Quasi-)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis. Angew.Chem.Int.Ed.Engl., 53, 2014
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4OIJ
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![BU of 4oij by Molmil](/molmil-images/mine/4oij) | X-ray crystal structure of racemic non-glycosylated chemokine Ser-CCL1 | Descriptor: | C-C motif chemokine 1, D-Ser-CCL1, SULFATE ION | Authors: | Okamoto, R, Mandal, K, Sawaya, M.R, Kajihara, Y, Yeates, T.O, Kent, S.B.H. | Deposit date: | 2014-01-19 | Release date: | 2014-05-07 | Last modified: | 2014-05-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | (Quasi-)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis. Angew.Chem.Int.Ed.Engl., 53, 2014
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