8HVP

STRUCTURE AT 2.5-ANGSTROMS RESOLUTION OF CHEMICALLY SYNTHESIZED HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 PROTEASE COMPLEXED WITH A HYDROXYETHYLENE*-BASED INHIBITOR

Summary for 8HVP

Related PRD IDPRD_000362
DescriptorHIV-1 PROTEASE, INHIBITOR VAL-SER-GLN-ASN-LEU-PSI(CH(OH)-CH2)-VAL-ILE-VAL (U-85548E) (3 entities in total)
Functional Keywordsacid proteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman immunodeficiency virus 1
Cellular locationGag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion  P03369
Total number of polymer chains3
Total molecular weight22401.33
Authors
Jaskolski, M.,Miller, M.,Tomasselli, A.G.,Sawyer, T.K.,Staples, D.G.,Heinrikson, R.L.,Schneider, J.,Kent, S.B.H.,Wlodawer, A. (deposition date: 1990-10-26, release date: 1993-10-31, Last modification date: 2017-11-29)
Primary citation
Jaskolski, M.,Tomasselli, A.G.,Sawyer, T.K.,Staples, D.G.,Heinrikson, R.L.,Schneider, J.,Kent, S.B.,Wlodawer, A.
Structure at 2.5-A resolution of chemically synthesized human immunodeficiency virus type 1 protease complexed with a hydroxyethylene-based inhibitor.
Biochemistry, 30:1600-1609, 1991
PubMed: 1993177 (PDB entries with the same primary citation)
DOI: 10.1021/bi00220a023
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers373.1%13.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 8hvp
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Molmil generated image of 8hvp
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Molmil generated image of 8hvp
rotated about y axis by 90°