3ODV
X-ray structure of kaliotoxin by racemic protein crystallography
Summary for 3ODV
| Entry DOI | 10.2210/pdb3odv/pdb |
| Descriptor | Potassium channel toxin alpha-KTx 3.1, trifluoroacetic acid, CITRIC ACID, ... (4 entities in total) |
| Functional Keywords | racemic protein, direct methods, toxin, chemical synthesis |
| Biological source | Androctonus mauretanicus mauretanicus (Scorpion) |
| Cellular location | Secreted: P24662 |
| Total number of polymer chains | 2 |
| Total formula weight | 8942.40 |
| Authors | Pentelute, B.L.,Mandal, K.,Gates, Z.P.,Sawaya, M.R.,Yeates, T.O.,Kent, S.B.H. (deposition date: 2010-08-11, release date: 2010-10-20, Last modification date: 2024-10-16) |
| Primary citation | Pentelute, B.L.,Mandal, K.,Gates, Z.P.,Sawaya, M.R.,Yeates, T.O.,Kent, S.B. Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography. Chem.Commun.(Camb.), 46:8174-8176, 2010 Cited by PubMed Abstract: Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of D- and L-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1 that diffracted to atomic-resolution (0.95 Å), enabling the X-ray structure of kaliotoxin to be determined by direct methods. PubMed: 20877851DOI: 10.1039/c0cc03148h PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (0.95 Å) |
Structure validation
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