1KEQ
| Crystal Structure of F65A/Y131C Carbonic Anhydrase V, covalently modified with 4-chloromethylimidazole | 分子名称: | 4-METHYLIMIDAZOLE, ACETIC ACID, F65A/Y131C-MI Carbonic Anhydrase V, ... | 著者 | Jude, K.M, Wright, S.K, Tu, C, Silverman, D.N, Viola, R.E, Christianson, D.W. | 登録日 | 2001-11-16 | 公開日 | 2002-03-06 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle. Biochemistry, 41, 2002
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6WDQ
| IL23/IL23R/IL12Rb1 signaling complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-12 receptor subunit beta-1, ... | 著者 | Jude, K.M, Ely, L.K, Glassman, C.R, Thomas, C, Spangler, J.B, Lupardus, P.J, Garcia, K.C. | 登録日 | 2020-04-01 | 公開日 | 2021-02-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis for IL-12 and IL-23 receptor sharing reveals a gateway for shaping actions on T versus NK cells. Cell, 184, 2021
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6OEL
| Engineered Fab bound to IL-4 receptor | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, Interleukin-4 receptor subunit alpha, ... | 著者 | Jude, K.M, Moraga, I, Spangler, J.B, Garcia, K.C. | 登録日 | 2019-03-27 | 公開日 | 2019-08-07 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | A strategy for the selection of monovalent antibodies that span protein dimer interfaces. J.Biol.Chem., 294, 2019
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6E3K
| Interferon gamma signalling complex with IFNGR1 and IFNGR2 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Jude, K.M, Mendoza, J.L, Garcia, K.C. | 登録日 | 2018-07-14 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
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6E3L
| Interferon gamma signalling complex with IFNGR1 and IFNGR2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CYSTEINE, ... | 著者 | Jude, K.M, Mendoza, J.L, Garcia, K.C. | 登録日 | 2018-07-14 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.8 Å) | 主引用文献 | Structure of the IFN gamma receptor complex guides design of biased agonists. Nature, 567, 2019
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8FFE
| Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | 登録日 | 2022-12-08 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
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8FRE
| Designed loop protein RBL4 | 分子名称: | 1,2-ETHANEDIOL, RBL4 | 著者 | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | 登録日 | 2023-01-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | De novo design of buttressed loops for sculpting protein functions. Nat.Chem.Biol., 20, 2024
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8FRF
| Homodimeric designed loop protein RBL7_C2_3 | 分子名称: | MALONATE ION, RBL7_C2_3 | 著者 | Jude, K.M, Jiang, H, Baker, D, Garcia, K.C. | 登録日 | 2023-01-06 | 公開日 | 2024-04-17 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | De novo design of buttressed loops for sculpting protein functions. Nat.Chem.Biol., 20, 2024
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6DG5
| Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit gamma, ... | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.516 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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2FOU
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2FOQ
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2FOV
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2FOY
| Human Carbonic Anhydrase I complexed with a two-prong inhibitor | 分子名称: | Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER | 著者 | Jude, K.M, Banerjee, A.L, Haldar, M.K, Manokaran, S, Roy, B, Mallik, S, Srivastava, D.K, Christianson, D.W. | 登録日 | 2006-01-14 | 公開日 | 2006-04-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128, 2006
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2FOS
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6DG6
| Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | 分子名称: | Neoleukin-2/15 | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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8VSJ
| Engineered peptide-specific binder in complex with HLA-DR1/CLIP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Class-II-associated invariant chain peptide, HLA class II histocompatibility antigen DR beta chain, ... | 著者 | Jude, K.M, Yang, X, Du, H, Kassardjian, A, Julien, J.-P, Huang, P, Garcia, K.C. | 登録日 | 2024-01-24 | 公開日 | 2024-10-02 | 実験手法 | ELECTRON MICROSCOPY (2.28 Å) | 主引用文献 | Differentiating MHC-II antigens with a single loop To Be Published
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6MOH
| Dimeric DARPin C_R3 complex with EpoR | 分子名称: | Dimeric DARPin E2C (C_R3), Erythropoietin receptor, PHOSPHATE ION, ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOI
| Dimeric DARPin C_angle_R5 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Dimeric DARPing CCR5 (C_angle_R5), ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.065 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOE
| Monomeric DARPin E2 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, E2 DARPin, ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOF
| Monomeric DARPin G2 complex with EpoR | 分子名称: | 1,2-ETHANEDIOL, Erythropoietin receptor, G2 DARPin | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOL
| Monoextended DARPin M_R12 complex with EpoR | 分子名称: | Erythropoietin receptor, GLYCEROL, Monoextended DARPin R12 (M_R12) | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (3.163 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOG
| Dimeric DARPin C_R3 | 分子名称: | 1,2-ETHANEDIOL, DARPin C_R3, TRIETHYLENE GLYCOL | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOK
| Dimeric DARPin A_distance_R7 complex with EpoR | 分子名称: | Dimeric DARPin ANR7 (A_distance_r7), Erythropoietin receptor | 著者 | Jude, K.M, Mohan, K, Garcia, K.C, Guo, Y. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (5.101 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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6MOJ
| Dimeric DARPin A_angle_R5 complex with EpoR | 分子名称: | D(-)-TARTARIC ACID, Dimeric DARPin ACR5 (A_angle_R5), Erythropoietin receptor, ... | 著者 | Jude, K.M, Mohan, K, Garcia, K.C. | 登録日 | 2018-10-04 | 公開日 | 2019-06-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.431 Å) | 主引用文献 | Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science, 364, 2019
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5WB1
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