6DG6

Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic

Summary for 6DG6

DescriptorNeoleukin-2/15 (2 entities in total)
Functional Keywordscytokine mimetic, biosynthetic protein
Biological sourcesynthetic construct
Total number of polymer chains6
Total molecular weight72677.03
Authors
Jude, K.M.,Silva, D.-A.,Yu, S.,Baker, D.,Garcia, K.C. (deposition date: 2018-05-16, release date: 2019-01-16, Last modification date: 2019-01-23)
Primary citation
Silva, D.A.,Yu, S.,Ulge, U.Y.,Spangler, J.B.,Jude, K.M.,Labao-Almeida, C.,Ali, L.R.,Quijano-Rubio, A.,Ruterbusch, M.,Leung, I.,Biary, T.,Crowley, S.J.,Marcos, E.,Walkey, C.D.,Weitzner, B.D.,Pardo-Avila, F.,Castellanos, J.,Carter, L.,Stewart, L.,Riddell, S.R.,Pepper, M.,Bernardes, G.J.L.,Dougan, M.,Garcia, K.C.,Baker, D.
De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565:186-191, 2019
PubMed: 30626941 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-018-0830-7
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.999 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.22620 0.6% 6.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6dg6
no rotation
Molmil generated image of 6dg6
rotated about x axis by 90°
Molmil generated image of 6dg6
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 6dg6
no rotation
Molmil generated image of 6dg6
rotated about x axis by 90°
Molmil generated image of 6dg6
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6dg6.pdb1.gz [35.42 KB])
Coordinate files for Biological unit (6dg6.pdb2.gz [36.16 KB])
Coordinate files for Biological unit (6dg6.pdb3.gz [35.65 KB])
Coordinate files for Biological unit (6dg6.pdb4.gz [35.28 KB])
Coordinate files for Biological unit (6dg6.pdb5.gz [34.56 KB])
Coordinate files for Biological unit (6dg6.pdb6.gz [32.86 KB])