2FOY

Human Carbonic Anhydrase I complexed with a two-prong inhibitor

Summary for 2FOY

Entry DOI	10.2210/pdb2foy/pdb
Related	1HCB 2FOQ 2FOS 2FOU 2FOV
Descriptor	Carbonic anhydrase 1, ZINC ION, {2,2'-[(2-{[4-(AMINOSULFONYL)BENZOYL]AMINO}ETHYL)IMINO]DIACETATO(2-)-KAPPAO}COPPER, ... (4 entities in total)
Functional Keywords	lyase, zinc, inhibitor, copper
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P00915
Total number of polymer chains	2
Total formula weight	60206.10
Authors	Jude, K.M.,Banerjee, A.L.,Haldar, M.K.,Manokaran, S.,Roy, B.,Mallik, S.,Srivastava, D.K.,Christianson, D.W. (deposition date: 2006-01-14, release date: 2006-04-04, Last modification date: 2023-08-30)
Primary citation	Jude, K.M.,Banerjee, A.L.,Haldar, M.K.,Manokaran, S.,Roy, B.,Mallik, S.,Srivastava, D.K.,Christianson, D.W. Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with two-prong inhibitors reveal the molecular basis of high affinity. J.Am.Chem.Soc., 128:3011-3018, 2006 Cited by PubMed: 16506782 DOI: 10.1021/ja057257n PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation