Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg

Summary for 6DG5

DescriptorNeoleukin-2/15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ... (8 entities in total)
Functional Keywordscytokine mimetic, cytokine receptor complex, biosynthetic protein, biosynthetic protein-protein binding complex, biosynthetic protein/protein binding
Biological sourcesynthetic construct
Total number of polymer chains3
Total molecular weight62594.47
Jude, K.M.,Silva, D.-A.,Yu, S.,Baker, D.,Garcia, K.C. (deposition date: 2018-05-16, release date: 2019-01-16, Last modification date: 2019-01-23)
Primary citation
Silva, D.A.,Yu, S.,Ulge, U.Y.,Spangler, J.B.,Jude, K.M.,Labao-Almeida, C.,Ali, L.R.,Quijano-Rubio, A.,Ruterbusch, M.,Leung, I.,Biary, T.,Crowley, S.J.,Marcos, E.,Walkey, C.D.,Weitzner, B.D.,Pardo-Avila, F.,Castellanos, J.,Carter, L.,Stewart, L.,Riddell, S.R.,Pepper, M.,Bernardes, G.J.L.,Dougan, M.,Garcia, K.C.,Baker, D.
De novo design of potent and selective mimics of IL-2 and IL-15.
Nature, 565:186-191, 2019
PubMed: 30626941 (PDB entries with the same primary citation)
DOI: 10.1038/s41586-018-0830-7
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.26640 3.8% 9.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution