6DG5
Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic complex with IL-2Rb and IL-2Rg
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Neoleukin-2/15 | polymer | 104 | 12112.8 | 1 | synthetic construct | ||
| 2 | B (B) | Interleukin-2 receptor subunit beta | polymer | 209 | 24469.9 | 1 | UniProt (P16297) Pfam (PF18707) | Mus musculus (Mouse) | IL-2RB,High affinity IL-2 receptor subunit beta,p70-75 |
| 3 | C (C) | Cytokine receptor common subunit gamma | polymer | 199 | 23799.7 | 1 | UniProt (P34902) Pfam (PF22012) Pfam (PF21605) | Mus musculus (Mouse) | Interleukin-2 receptor subunit gamma,IL-2RG,gammaC,p64 |
| 4 | D (D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1219.1 | 1 | In PDB GlyTouCan (G27389SR) | |||
| 6 | F, G (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 7 | H, I (B, C) | water | water | 18.0 | 13 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 60382.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1643.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 442.4 | |
| All* | Total formula weight | 62468.4 |
