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PDB: 34 件
6MNI
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BU of 6mni by Molmil
Structure of the tandem CACHE domain of PscC
分子名称: CHLORIDE ION, GLYCEROL, Methyl-accepting chemotaxis protein, ...
著者Johnston, J.M, Gerth, M.L, Ehrhardt, M.K.G.
登録日2018-10-01
公開日2019-10-16
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.696 Å)
主引用文献Structure of a double CACHE chemoreceptor ligand-binding domain from Pseudomonas syringae provides insights into the basis of proline recognition.
Biochem.Biophys.Res.Commun., 549, 2021
8F8K
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BU of 8f8k by Molmil
The structure of Rv2173 from M. tuberculosis with IPP bound
分子名称: (2E,6E)-farnesyl diphosphate synthase, 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, ACETATE ION, ...
著者Johnston, J.M, Allison, T.M, Titterington, J, Beasley, C.P.H.
登録日2022-11-22
公開日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
8F8F
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BU of 8f8f by Molmil
The structure of Rv2173 from M. tuberculosis (APO form)
分子名称: (2E,6E)-farnesyl diphosphate synthase, GLYCEROL, MAGNESIUM ION
著者Johnston, J.M, Allison, T.M, Titterington, J.
登録日2022-11-22
公開日2023-11-29
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
8F8L
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The structure of Rv2173 from M. tuberculosis with DMAP bound
分子名称: (2E,6E)-farnesyl diphosphate synthase, CALCIUM ION, DIMETHYLALLYL DIPHOSPHATE, ...
著者Johnston, J.M, Allison, T.M, Titterington, J.
登録日2022-11-22
公開日2023-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The structure of Rv2173 from M. tuberculosis in APO-, IPP-, and DMAP-bound forms.
To be Published
6O04
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M.tb MenD IntII bound with Inhibitor
分子名称: (1~{R},2~{S},5~{S},6~{S})-2-[(1~{S})-1-[3-[(4-azanylidene-2-methyl-1~{H}-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl (phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-1,4-bis(oxidanyl)-4-oxidanylidene-butyl]-6-oxidanyl-5-(3-oxid anyl-3-oxidanylidene-prop-1-en-2-yl)oxy-cyclohex-3-ene-1-carboxylic acid, 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ...
著者Johnston, J.M, Bashiri, G, Bulloch, E.M, Jirgis, E.M.N, Nigon, L.V, Chuang, H, Baker, E.N.
登録日2019-02-15
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
J.Biol.Chem., 295, 2020
6O0G
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BU of 6o0g by Molmil
M.tb MenD bound to Intermediate I and Inhibitor
分子名称: 1,4-dihydroxy-2-naphthoic acid, 2-OXOGLUTARIC ACID, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ...
著者Johnston, J.M, Bashiri, G, Bulloch, E.M.M, Jirgis, E.M.N, Chuang, H, Nigon, L.V, Baker, E.N.
登録日2019-02-16
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
J.Biol.Chem., 295, 2020
6O0J
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M.tb MenD with ThDP and Inhibitor bound
分子名称: 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ACETATE ION, ...
著者Johnston, J.M, Bashiri, G, Bulloch, E.M.M, Jirgis, E.M.N, Nigon, L.V, Chuang, H, Ho, N.A.T, Baker, E.N.
登録日2019-02-16
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
J.Biol.Chem., 295, 2020
6O0N
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BU of 6o0n by Molmil
M.tb MenD with Inhibitor
分子名称: 1,4-dihydroxy-2-naphthoic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
著者Johnston, J.M, Ho, N.A.T, Bashiri, G, Bulloch, E.M, Nigon, L.V, Jirgis, E.M.N, Baker, E.N.
登録日2019-02-16
公開日2020-02-19
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogenMycobacterium tuberculosis.
J.Biol.Chem., 295, 2020
7TIN
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BU of 7tin by Molmil
The Structure of S. aureus MenD
分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, CALCIUM ION, CHLORIDE ION, ...
著者Johnston, J.M, Stanborough, T, Ho, N.A.T, Akazong, E.W, Jiao, W.
登録日2022-01-14
公開日2022-09-14
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Allosteric inhibition of Staphylococcus aureus MenD by 1,4-dihydroxy naphthoic acid: a feedback inhibition mechanism of the menaquinone biosynthesis pathway.
Philos.Trans.R.Soc.Lond.B Biol.Sci., 378, 2023
5ERY
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BU of 5ery by Molmil
Crystal Structure of APO MenD from M. tuberculosis - P212121
分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
著者Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N.
登録日2015-11-16
公開日2016-06-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESO
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BU of 5eso by Molmil
Crystal Structure of M. tuberculosis MenD with ThDP, Mg2+ and Isochorismate bound
分子名称: (5S,6S)-5-[(1-carboxyethenyl)oxy]-6-hydroxycyclohexa-1,3-diene-1-carboxylic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, BETA-MERCAPTOETHANOL, ...
著者Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N.
登録日2015-11-16
公開日2016-06-22
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESS
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BU of 5ess by Molmil
Crystal Structure of M. tuberculosis MenD bound to Mg2+ and covalent intermediate I (a ThDP and decarboxylated 2-oxoglutarate adduct)
分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, 4-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3 -ium-2-yl]-4-oxidanyl-butanoic acid, ACETATE ION, ...
著者Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N.
登録日2015-11-17
公開日2016-06-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESU
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BU of 5esu by Molmil
Crystal Structure of M. tuberculosis MenD bound to Mg2+ and Covalent Intermediate II (a ThDP + de-carboxylated 2-oxoglutarate + Isochorismate adduct)
分子名称: (1~{R},2~{S},5~{S},6~{S})-2-[(1~{S})-1-[3-[(4-azanylidene-2-methyl-1~{H}-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl (phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-1,4-bis(oxidanyl)-4-oxidanylidene-butyl]-6-oxidanyl-5-(3-oxid anyl-3-oxidanylidene-prop-1-en-2-yl)oxy-cyclohex-3-ene-1-carboxylic acid, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, BETA-MERCAPTOETHANOL, ...
著者Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N.
登録日2015-11-17
公開日2016-06-22
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ERX
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BU of 5erx by Molmil
Crystal Structure of APO MenD from M. tuberculosis - I222
分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase
著者Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N.
登録日2015-11-16
公開日2016-06-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.729 Å)
主引用文献Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5ESD
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BU of 5esd by Molmil
Crystal Structure of M. tuberculosis MenD bound to ThDP and Mn2+
分子名称: 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, MANGANESE (II) ION, THIAMINE DIPHOSPHATE
著者Johnston, J.M, Jirgis, E.N.M, Bashiri, G, Bulloch, E.M.M, Baker, E.N.
登録日2015-11-16
公開日2016-06-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structural Views along the Mycobacterium tuberculosis MenD Reaction Pathway Illuminate Key Aspects of Thiamin Diphosphate-Dependent Enzyme Mechanisms.
Structure, 24, 2016
5FCC
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BU of 5fcc by Molmil
Structure of HutD from Pseudomonas fluorescens SBW25 (NaCl condition)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, HutD, ...
著者Johnston, J.M, Gerth, M.L, Baker, E.N, Lott, J.S, Rainey, P.B.
登録日2015-12-15
公開日2017-01-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structure of HutD from Pseudomonas fluorescens
To Be Published
5CWA
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BU of 5cwa by Molmil
Structure of Anthranilate Synthase Component I (TrpE) from Mycobacterium tuberculosis with inhibitor bound
分子名称: 3-{[(1Z)-1-carboxyprop-1-en-1-yl]oxy}-2-hydroxybenzoic acid, Anthranilate synthase component 1, GLYCEROL, ...
著者Johnston, J.M, Bashiri, G, Evans, G.L, Lott, J.S, Baker, E.N.
登録日2015-07-28
公開日2015-08-12
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
Acta Crystallogr.,Sect.D, 71, 2015
4GDM
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BU of 4gdm by Molmil
Crystal Structure of E.coli MenH
分子名称: 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, CHLORIDE ION, GLYCEROL, ...
著者Johnston, J.M, Baker, E.N, Guo, Z, Jiang, M.
登録日2012-07-31
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
Plos One, 8, 2013
4GEG
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BU of 4geg by Molmil
Crystal Structure of E.coli MenH Y85F Mutant
分子名称: 1,2-ETHANEDIOL, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, CHLORIDE ION, ...
著者Johnston, J.M, Baker, E.N, Guo, Z, Jiang, M.
登録日2012-08-01
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
Plos One, 8, 2013
4GEC
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BU of 4gec by Molmil
Crystal Structure of E.coli MenH R124A Mutant
分子名称: 1,2-ETHANEDIOL, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase, CHLORIDE ION, ...
著者Johnston, J.M, Baker, E.N, Guo, Z, Jiang, M.
登録日2012-08-01
公開日2013-05-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal Structures of E. coli Native MenH and Two Active Site Mutants.
Plos One, 8, 2013
3HSS
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BU of 3hss by Molmil
A higher resolution structure of Rv0554 from Mycobacterium tuberculosis complexed with malonic acid
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
著者Johnston, J.M, Baker, E.N.
登録日2009-06-10
公開日2010-05-26
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis.
Acta Crystallogr.,Sect.D, 66, 2010
3E3A
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BU of 3e3a by Molmil
The Structure of Rv0554 from Mycobacterium tuberculosis
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, POSSIBLE PEROXIDASE BPOC
著者Johnston, J.M, Baker, E.N.
登録日2008-08-06
公開日2009-06-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis.
Acta Crystallogr.,Sect.D, 66, 2010
3HYS
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BU of 3hys by Molmil
Structure of Rv0554 from Mycobacterium tuberculosis complexed with Malonic Acid
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MALONIC ACID, ...
著者Johnston, J.M, Baker, E.N.
登録日2009-06-23
公開日2010-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis.
Acta Crystallogr.,Sect.D, 66, 2010
3HZO
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BU of 3hzo by Molmil
Rv0554 from Mycobacterium tuberculosis - the structure solved from the tetragonal crystal form
分子名称: 1,2-ETHANEDIOL, MALONIC ACID, SODIUM ION, ...
著者Johnston, J.M, Baker, E.N.
登録日2009-06-23
公開日2010-06-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure of Rv0554 from Mycobacterium tuberculosis
To be Published
1NXJ
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BU of 1nxj by Molmil
Structure of Rv3853 from Mycobacterium tuberculosis
分子名称: GLYOXYLIC ACID, L(+)-TARTARIC ACID, Probable S-adenosylmethionine:2-demethylmenaquinone methyltransferase
著者Johnston, J.M, Arcus, V.L, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
登録日2003-02-10
公開日2003-07-29
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal Structure of a Putative Methyltransferase from Mycobacterium tuberculosis: Misannotation of a Genome Clarified by Protein Structural Analysis
J.Bacteriol., 185, 2003

 

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