7N50
| |
7N51
| |
7N52
| |
8GBE
| |
1AKS
| CRYSTAL STRUCTURE OF THE FIRST ACTIVE AUTOLYSATE FORM OF THE PORCINE ALPHA TRYPSIN | Descriptor: | ALPHA TRYPSIN, CALCIUM ION | Authors: | Johnson, A, Krishnaswamy, S, Sundaram, P.V, Pattabhi, V. | Deposit date: | 1996-07-24 | Release date: | 1997-02-12 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | The first structure at 1.8 A resolution of an active autolysate form of porcine alpha-trysoin. Acta Crystallogr.,Sect.D, 53, 1997
|
|
8SL0
| |
8SS1
| |
8SRZ
| |
1QQU
| |
2OZR
| MMP13 Catalytic Domain Complexed with 4-{[1-methyl-2,4-dioxo-6-(3-phenylprop-1-yn-1-yl)-1,4-dihydroquinazolin-3(2H)-yl]methyl}benzoic acid | Descriptor: | 4-{[1-METHYL-2,4-DIOXO-6-(3-PHENYLPROP-1-YN-1-YL)-1,4-DIHYDROQUINAZOLIN-3(2H)-YL]METHYL}BENZOIC ACID, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | Authors: | Johnson, A.R, Pavlovsky, A.G, Ortwine, D.F, Prior, F, Man, C.-F, Bornemeier, D.A, Banotai, C.A, Mueller, W.T, McConnell, P, Yan, C.H, Baragi, V, Lesch, C, Roark, W.H, Lie, J.J, Fasquelle, V, Wilson, M, Robertson, D, Datta, K, Guzman, R, Han, H.-K, Dyer, R.D. | Deposit date: | 2007-02-27 | Release date: | 2007-07-24 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia side effects. J.Biol.Chem., 282, 2007
|
|
7VJY
| |
6N8O
| Cryo-EM structure of Rpl10-inserted (RI) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
|
|
6N8M
| Cryo-EM structure of pre-Lsg1 (PL) pre-60S ribosomal subunit | Descriptor: | 5.8S RNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
|
|
6N8N
| Cryo-EM structure of Lsg1-engaged (LE) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
|
|
6N8J
| Cryo-EM structure of late nuclear (LN) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal protein L11-A, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
|
|
6N8L
| Cryo-EM structure of early cytoplasmic-late (ECL) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
|
|
1APL
| CRYSTAL STRUCTURE OF A MAT-ALPHA2 HOMEODOMAIN-OPERATOR COMPLEX SUGGESTS A GENERAL MODEL FOR HOMEODOMAIN-DNA INTERACTIONS | Descriptor: | DNA (5'-D(*AP*CP*AP*TP*GP*TP*AP*AP*TP*TP*CP*AP*TP*TP*TP*AP*C P*AP*CP*GP*C)-3'), DNA (5'-D(*TP*GP*CP*GP*TP*GP*TP*AP*AP*AP*TP*GP*AP*AP*TP*TP*A P*CP*AP*TP*G)-3'), PROTEIN (MAT-ALPHA2 HOMEODOMAIN) | Authors: | Wolberger, C, Vershon, A.K, Liu, B, Johnson, A.D, Pabo, C.O. | Deposit date: | 1993-10-04 | Release date: | 1993-10-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of a MAT alpha 2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions. Cell(Cambridge,Mass.), 67, 1991
|
|
7UG6
| Cryo-EM structure of pre-60S ribosomal subunit, unmethylated G2922 | Descriptor: | 25S rRNA, 5.8S rRNA, 5S rRNA, ... | Authors: | Yelland, J.N, Bravo, J.P.K, Black, J.J.B, Taylor, D.W, Johnson, A.W. | Deposit date: | 2022-03-24 | Release date: | 2022-12-21 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | A single 2'-O-methylation of ribosomal RNA gates assembly of a functional ribosome. Nat.Struct.Mol.Biol., 30, 2023
|
|
4GVJ
| Tyk2 (JH1) in complex with adenosine di-phosphate | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Non-receptor tyrosine-protein kinase TYK2 | Authors: | Liang, J, Abbema, A.V, Bao, L, Barrett, K, Beresini, M, Berezhkovskiy, L, Blair, W, Chang, C, Driscoll, J, Eigenbrot, C, Ghilardi, N, Gibbons, P, Halladay, J, Johnson, A, Kohli, P.B, Lai, Y, Liimatta, M, Mantik, P, Menghrajani, K, Murray, J, Sambrone, A, Shao, Y, Shia, S, Shin, Y, Smith, J, Sohn, S, Stanley, M, Tsui, V, Ultsch, M, Wu, L, Zhang, B, Magnuson, S. | Deposit date: | 2012-08-30 | Release date: | 2013-08-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Lead identification of novel and selective TYK2 inhibitors. Eur.J.Med.Chem., 67, 2013
|
|
8FNW
| Structure of RdrA-RdrB complex from Escherichia coli RADAR defense system | Descriptor: | Adenosine deaminase, Archaeal ATPase, ZINC ION | Authors: | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | Deposit date: | 2022-12-28 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (6.73 Å) | Cite: | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
|
|
8FNT
| Structure of RdrA from Escherichia coli RADAR defense system | Descriptor: | Archaeal ATPase | Authors: | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | Deposit date: | 2022-12-28 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
|
|
8FNV
| Structure of RdrB from Escherichia coli RADAR defense system | Descriptor: | Adenosine deaminase, ZINC ION | Authors: | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | Deposit date: | 2022-12-28 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.11 Å) | Cite: | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
|
|
8FNU
| Structure of RdrA from Streptococcus suis RADAR defense system | Descriptor: | KAP NTPase domain-containing protein | Authors: | Duncan-Lowey, B, Johnson, A.G, Rawson, S, Mayer, M.L, Kranzusch, P.J. | Deposit date: | 2022-12-28 | Release date: | 2023-02-01 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Cryo-EM structure of the RADAR supramolecular anti-phage defense complex. Cell, 186, 2023
|
|
6N8K
| Cryo-EM structure of early cytoplasmic-immediate (ECI) pre-60S ribosomal subunit | Descriptor: | 5.8S rRNA, 5S rRNA, 60S ribosomal export protein NMD3, ... | Authors: | Zhou, Y, Musalgaonkar, S, Johnson, A.W, Taylor, D.W. | Deposit date: | 2018-11-29 | Release date: | 2019-03-13 | Last modified: | 2020-01-08 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Tightly-orchestrated rearrangements govern catalytic center assembly of the ribosome. Nat Commun, 10, 2019
|
|
4KL1
| HCN4 CNBD in complex with cGMP | Descriptor: | ACETATE ION, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, ... | Authors: | Lolicato, M, Arrigoni, C, Zucca, S, Nardini, M, Bucchi, A, Schroeder, I, Simmons, K, Bolognesi, M, DiFrancesco, D, Schwede, F, Fishwick, C.W.G, Johnson, A.P.K, Thiel, G, Moroni, A. | Deposit date: | 2013-05-07 | Release date: | 2014-04-30 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nat.Chem.Biol., 10, 2014
|
|