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4GVJ

Tyk2 (JH1) in complex with adenosine di-phosphate

Summary for 4GVJ
Entry DOI10.2210/pdb4gvj/pdb
Related4GFM 4GFO 4GIH 4GII 4GJ2 4GJ3 4GMY
DescriptorNon-receptor tyrosine-protein kinase TYK2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
Functional Keywordskinase, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight35225.53
Authors
Primary citationLiang, J.,Tsui, V.,Van Abbema, A.,Bao, L.,Barrett, K.,Beresini, M.,Berezhkovskiy, L.,Blair, W.S.,Chang, C.,Driscoll, J.,Eigenbrot, C.,Ghilardi, N.,Gibbons, P.,Halladay, J.,Johnson, A.,Kohli, P.B.,Lai, Y.,Liimatta, M.,Mantik, P.,Menghrajani, K.,Murray, J.,Sambrone, A.,Xiao, Y.,Shia, S.,Shin, Y.,Smith, J.,Sohn, S.,Stanley, M.,Ultsch, M.,Zhang, B.,Wu, L.C.,Magnuson, S.
Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67:175-187, 2013
Cited by
PubMed: 23867602
DOI: 10.1016/j.ejmech.2013.03.070
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

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